Search results for " aging"
showing 10 items of 584 documents
How Important Are Genes to Achieve Longevity?
2022
Several studies on the genetics of longevity have been reviewed in this paper. The results show that, despite efforts and new technologies, only two genes, APOE and FOXO3A, involved in the protection of cardiovascular diseases, have been shown to be associated with longevity in nearly all studies. This happens because the genetic determinants of longevity are dynamic and depend on the environmental history of a given population. In fact, population-specific genes are thought to play a greater role in the attainment of longevity than those shared between different populations. Hence, it is not surprising that GWAS replicated associations of common variants with longevity have been few, if an…
A SOCIAL EXPERIMENT TO OVERTURN PREJUDICES ON ALZHEIMER’S DISEASE IN NURSING HOMES USING ARTISTIC PHOTOGRAPHY
2016
It is widely known that Alzheimer’s disease is burdened with strong prejudices with negative connotations. This may contribute to increase patient’s isolation and marginalization, and to render Nursing Homes places of confinement and seclusion. Residents with dementia have trouble in relating with the outside world and in expressing themselves about their own disease, due to their cognitive decline, but also because of marginalization. We used artistic photography as an accessible and effective tool to bring down barriers and encourage residents’ communication. Artistic photography is the most immediate and accessible form of art for all people. The aim of our social experiment was to help …
OXIDATIVE STRESS AND ALZHEIMER’S DISEASE
2012
Introduction: Brain tissue is particularly susceptible to oxidative damage, which has been associated with pathological findings of Alzheimer’s disease (AD), such as amyloid plaques and protein fibrils. Oxidative stress alterations, including increased production of reactive oxygen metabolites, decline of antioxidant systems, and decreased efficiency in repairing damaged molecules, have been linked to the development of AD. Postmortem studies on brain tissue from AD patients have shown several oxidative damage markers, such as increased lipid peroxidation, oxidative damage of proteins, glyco-oxidation, and reduction of antioxidant enzyme systems. Methods: We studied 40 patients referred to …
BPCO E OSTEOPOROSI
2013
COPD and osteoporosis are frequently associated because they have common risk factors, including age, smoking habits and reduced physical activity. COPD is also characterized by systemic inflammation, malnutrition (up to cachexia), hypovitaminosis D, and the use of local and systemic corticosteroids, all of which could cause deterioration in bone quality with a consequent increase in fragility fractures. These fractures may further impair mobility and increase disability and mortality. The vertebral and rib fractures can directly further affect lung function and promote exacerbations. As a result, the assessment of fracture risk in patients with COPD is of vital importance from the earliest…
Nutritional prevention of cognitive decline and dementia.
2018
Cognitive impairment results from a complex interplay of many factors. The most important independent predictor of cognitive decline is age but other contributing factors include demographic, genetic, socio-economic, and environmental parameters, including nutrition. The number of persons with cognitive decline and dementia will increase in the next decades in parallel with aging of the world population. Effective pharmaceutical treatments for age-related cognitive decline are lacking, emphasizing the importance of prevention strategies. There is extensive evidence supporting a relationship between diet and cognitive functions. Thus, nutritional approaches to prevent or slow cognitive decli…
Oral magnesium supplementation improves vascular function in elderly diabetic patients
2010
Magnesium (Mg) ions directly influence vascular tone and responsiveness and are cofactors for acetylcholine-induced endothelium-dependent relaxation. Alterations in extracellular Mg are able to modify the formation and release of nitric oxide (NO), altering arterial smooth muscle tone. Previous in vivo studies in humans have shown that parenteral or oral Mg supplementation increase endothelial-dependent vasodilation. The aim of the present study was to evaluate the effects of Mg oral supplementation on endothelial function in elderly diabetic and hypertensive subjects. Sixty elderly (≥ 65 years) diabetic patients were recruited (mean age: 71.1 ± 6.1 years; M/F: 35/25). Endothelial function,…
Magnesium Role in Health and Longevity Final
2018
Reduced Magnesium (Mg intake) is a frequent cause of Mg deficit with age. A decreased intestinal Mg absorption and an increased Mg loss may also contribute, as well as the use of medicaments. Mg requirements may be higher with aging. Alterations of Mg metabolism with age, cellular Mg transport systems and problems with measurement methods are discussed. Mg contained in water is more bio-available than Mg in food and it is a possible alternative to Mg supplementation in the correction of Mg deficiencies. Mild to moderate Mg deficits are generally asymptomatic and clinical signs are usually absent or non-specific. Hyperemotionality, tremor, asthenia, sleep disorders, and amnesic and cognitive…
ANORESSIA SENILE
2009
Malgrado l’elevata e crescente prevalenza del sovrappeso, il principale problema nutrizionale nell’anziano è rappresentato dalla malnutrizione per difetto spesso secondaria a riduzione dell’introito alimentare ed alla perdita di motivazione all’assunzione di cibo. Ciò fa pensare alla presenza nell’età senile di problemi correlati alla regolazione del bilancio energetico ed al controllo del senso della fame e della sazietà. L’anoressia conseguente all’invecchiamento rappresenta una causa comune di malnutrizione che è associata ad un aumento della mortalità e della disabilità funzionale.
Antiaging Medicine
2009
• The factors best demonstrated to delay aging are fruit and vegetables, exercise, not smoking, drinking one or two glasses of alcohol daily, and fish consumption. • Vitamin D replacement, in persons with low 25[OH] vitamin D levels, decreases hip fractures, improves muscle strength, enhances function, and decreases mortality. • Antiaging medicine has been hijacked by charlatans who promote unproven or dangerous remedies to a naïve aging public. • Too often animal studies that produce longevity are directly applied to humans before appropriate clinical trials have been carried out. • There is no evidence that hormones or megadoses of vitamins prolong life. • Numerous products of varying qua…