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Mechanisms of irreversible aquaporin-10 inhibition by organogold compounds studied by combined biophysical methods and atomistic simulations
2021
Abstract The inhibition of glycerol permeation via human aquaporin-10 (hAQP10) by organometallic gold complexes has been studied by stopped-flow fluorescence spectroscopy, and its mechanism has been described using molecular modelling and atomistic simulations. The most effective hAQP10 inhibitors are cyclometalated Au(III) C^N compounds known to efficiently react with cysteine residues leading to the formation of irreversible C–S bonds. Functional assays also demonstrate the irreversibility of the binding to hAQP10 by the organometallic complexes. The obtained computational results by metadynamics show that the local arylation of Cys209 in hAQP10 by one of the gold inhibitors is mapped int…
The Effect of Electrolytic Solution Composition on the Structure, Corrosion, and Wear Resistance of PEO Coatings on AZ31 Magnesium Alloy
2020
Plasma electrolytic oxidation coatings were prepared in aluminate, phosphate, and silicate-based electrolytic solutions using a soft-sparking regime in a multi-frequency stepped process to compare the structure, corrosion, and wear characteristics of the obtained coatings on AZ31 magnesium alloy. The XRD results indicated that all coatings consist of MgO and MgF2, while specific products such as Mg2SiO4, MgSiO3, Mg2P2O7, and MgAl2O4 were also present in specimens based on the selected solution. Surface morphology of the obtained coatings was strongly affected by the electrolyte composition. Aluminate-containing coating showed volcano-like, nodular particles and craters distributed over the …
Synergistic effect of W incorporation and pulsed current mode on wear and tribocorrosion resistance of coatings grown by plasma electrolytic oxidatio…
2019
Ceramic coatings were grown by plasma electrolytic oxidation on 7075 Al alloy using unipolar and bipolar pulsed current waveforms with 20 and 40% cathodic duty cycles, from a silicate-based bath without and with the addition of Na2WO4. Pancake-like morphology was dominant on the coatings grown by unipolar waveform, while the bipolar waveforms promoted volcano-like morphology, increased the roughness of the coating surface and the formation of more compact layers. The coatings produced using the bipolar waveforms provided higher resistances toward both tribocorrosion and dry sliding conditions, while further improvement was achieved by the presence of tungsten. The coatings produced in tungs…
Introduzione (1. Perché osservare la vita urbana di un territorio liminare, 2. Localité e governance, 3. Disagi e devianze nell'"ultima Provincia", 4…
2008
Le famiglie di soggetti autistici, le giovani donne affette da disturbi del comportamento alimentare, gli alcolisti, i tossicodipendenti, i giovani a rischio devianza dei quartieri degradati e coloro che usufruiscono delle misure alternative alla detenzione sono alcune degli attori che, venendo a far parte di nuovi aggregati identitari, mappano i contesti locali in spazi simbolici, in localitè, società urbane incomplete che rinviano a nuove questioni sociali e a differenti derive cui il welfare locale cerca di rispondere. Nel tentativo di esplicitare il groviglio fra solidarietà e povertà, capitalizzazione dei legami e inadeguatezza della rete, progettualità sociale e limiti organizzativi, …
High Entropy Alloys for Energy Conversion and Storage: A Review of Grain Boundary Wetting Phenomena
2022
This research was funded by the Russian Ministry of Science and Higher Education (contract no. 075-15-2021-945 grant no. 13.2251.21.0013). Support from the University of the Basque Country (project GIU19/019) and from the Basque Government (project IT1714-22) is also acknowledged.
A Double Auction Mechanism for Virtual Resource Allocation in SDN-based Cellular Network
2016
The explosively growing demands for mobile traffic service bring both challenges and opportunities to wireless net- works, among which, wireless network virtualization is proposed as the main evolution towards 5G. In this paper, we first propose a Software Defined Network (SDN) based wireless virtualization architecture for enabling multi-flow transmission in order to save capital expenses (CapEx) and operation expenses (OpEx) significantly with multiple Infrastructures Providers (InPs) and multiple Mobile Virtual Network Operators (MVNOs). We for- mulate the virtual resource allocation problem with diverse QoS requirements as a social welfare maximization problem with transaction cost. Due…
Energy Efficient Optimization for Wireless Virtualized Small Cell Networks With Large-Scale Multiple Antenna
2017
Wireless network virtualization is envisioned as a promising framework to provide efficient and customized services for next-generation wireless networks. In wireless virtualized networks (WVNs), limited radio resources are shared among different services providers for providing services to different users with heterogeneous demands. In this paper, we propose a resource allocation scheme for an orthogonal frequency division multiplexing-based WVN, where one small cell base station equipped with a large number of antennas serves the users with different service requirements. In particular, with the objective to obtain the energy efficiency in the uplink, a joint power, subcarrier, and antenn…
Resource Allocation and Computation Offloading for Wireless Powered Mobile Edge Computing
2022
In this paper, we investigate a resource allocation and computation offloading problem in a heterogeneous mobile edge computing (MEC) system. In the considered system, a wireless power transfer (WPT) base station (BS) with an MEC sever is able to deliver wireless energy to the mobile devices (MDs), and the MDs can utilize the harvested energy for local computing or task offloading to the WPT BS or a Macro BS (MBS) with a stronger computing server. In particular, we consider that the WPT BS can utilize full- or half-duplex wireless energy transmission mode to empower the MDs. The aim of this work focuses on optimizing the offloading decision, full/half-duplex energy harvesting mode and energ…
Programas de intervención con hombres penados por violencia de género: el enfoque motivacional como aproximación para mejorar su eficacia
2020
La violencia de género es un problema de salud pública de proporciones epidémicas con serias consecuencias para la salud física y psicológica de las víctimas, sus hijos y la sociedad en su conjunto. Una de las aproximaciones para responder a esta problemática son los programas de intervención con maltratadores. Los meta-análisis que se han llevado a cabo para evaluar la eficacia de estos programas han mostrado tamaños del efecto pequeños. Debido a ello, se han propuesto nuevos acercamientos como vía para incrementar su eficacia, entre los que destacan las estrategias motivacionales. El objetivo de la presente tesis doctoral fue analizar el efecto de la inclusión de estrategias motivacionale…
Early and Later Predictors of Outcome in Brief Therapy: The Role of Real Relationship
2012
Objectives: The study examined whether clients who continued longer in brief therapy reported stronger associations of real relationship and working alliance with therapy outcome than clients who received very brief treatment. It also examined whether real relationship and working alliance assessed early in treatment predicted outcome differently from that assessed later in therapy. Method: Fifty clients (32 women; Mage = 22.3 years) were recruited from a university counseling center. Thirty- two clients (very brief therapy) completed the post-third session assessment of real relationship and working alliance, and 18 (brief therapy) had both the third and eighth assessment. Results: The rea…