Search results for " and ocular physiology"
showing 10 items of 237 documents
Truncated TrkB receptor-induced outgrowth of dendritic filopodia involves the p75 neurotrophin receptor.
2004
The Trk family of receptor tyrosine kinases and the p75 receptor (p75NTR) mediate the effects of neurotrophins on neuronal survival, differentiation and synaptic plasticity. The neurotrophin BDNF and its cognate receptor tyrosine kinase, TrkB.FL, are highly expressed in neurons of the central nervous system. At later stages in postnatal development the truncated TrkB splice variants (TrkB.T1, TrkB.T2) become abundant. However, the signalling and function of these truncated receptors remained largely elusive.We show that overexpression of TrkB.T1 in hippocampal neurons induces the formation of dendritic filopodia, which are known precursors of synaptic spines. The induction of filopodia by T…
Astrocytes in culture express the full-length Trk-B receptor and respond to brain derived neurotrophic factor by changing intracellular calcium level…
2000
Abstract Although cultured astroglial cells were reported to express exclusively the truncated non-catalytic Trk B receptor for brain-derived neurotrophic factor (BDNF), we detect here, using a sensitive ribonuclease protection assay, mRNAs for both truncated (TrkB–T) and the full length catalytic (TrkB–fl) form of BDNF receptor in developing cortical astrocytes and neurons in culture. Cortical neurons and immature astroglia, such as radial glia and proliferating astrocytes, express both the protein and mRNAs for TrkB-fl and TrkB-T, whereas the differentiation of astrocytes leads to a decrease in the trkB-fl mRNA, being the truncated TrkB the predominant receptor in differentiating and conf…
Infants and Children Making Sense of Scents
2017
This chapter summarizes research on the development of human olfactory skills to rely on different cues conveyed by odorants, such as odor quality, intensity, position in space, novelty/familiarity, and hedonic value. The sensory, neural, and psychological dimensions at the root of these early aptitudes remain poorly explored in humans, but one can safely affirm that any weak odor to which the infant has previously been nonadversely exposed will have a higher reinforcing value than any novel odor. Developmental differences in odor discrimination and appreciation are certainly causally multiple and may depend on general or olfaction-specific cognitive factors which can be traced back to pren…
The Asian Taenia and the possibility of cysticercosis
2000
In certain Asian countries, a third form of human Taenia, also known as the Asian Taenia, has been discovered. This Asian Taenia seems to be an intermediate between Taenia solium and T. saginata since in morphological terms it is similar to T. saginata, yet biologically, as it uses the same intermediate host (pigs), it is more akin to T. solium. Taenia solium causes human cysticercosis, while T. saginata does not. It is not known whether the Asian taeniid is able to develop to the larval stage in humans or not. The arguments proposed by those authors who consider it unlikely that the Asian Taenia causes human cysticercosis are: (a) its molecular similarities with T. saginata; (b) the absenc…
Perceptual odor blending is influenced by chemical complexity of odorant mixtures
2008
International audience; Perfumers and flavorists are familiar with odor blending phenomenon and often report that a minimum number of odorants has to be mixed for a good odor blend to arise. Previous studies in humans and animals suggested that a configural process could be involved in the perceptual analysis of mixtures of odorants. It has been proposed that the perceptual blending phenomenon corresponds to a configural perception of odorant mixtures. In the present study, we investigated the influence of chemical complexity on the configural perception of odorant mixtures. Six mixtures including 2 to 6 odorants as well as each unmixed odorant were assessed for their odor quality by a pane…
Both the number and perceptual quality of odorants control configural processing of odor mixture in human adults
2014
Both the number and perceptual quality of odorants control configural processing of odor mixture in human adults. 36. annual meeting - association for chemoreception sciences (AChemS XXXVI)
A biometic olfactory based biosensor combining electrochemistry and odorant-binding
2012
A biometic olfactory based biosensor combining electrochemistry and odorant-binding. Food Factory 2012
Morphological and molecular changes in mouse olfactory epithelium following postnatal odorant exposures
2011
Morphological and molecular changes in mouse olfactory epithelium following postnatal odorant exposures. 10. annual meeting of the french neuroscience society
Negative impact of high fructose diet on olfactory performances: behavioral and functional analysis
2014
Negative impact of high fructose diet on olfactory performances: behavioral and functional analysis. 9. Forum of Neuroscience FENS
Evidence for interactions between aroma compounds and the CB1 receptor: a way to regulate food intake?
2012
National audience; Obesity is a major cause of morbidity and mortality worldwide, characterised by a chronic imbalance of energy homeostasis. The regulation of dietary intake appears to be an effective way to regulate this imbalance. Furthermore, it is now well established that the endocannabinoid system influences appetite via the cannabinoid receptor type 1 (CB1): CB1 agonists can promote food intake while CB1 antagonists tend to decrease appetite (1). Interestingly, recent studies showed that CB1-like receptors are expressed in the olfactory epithelium of Xenopus laevis tadpoles (2). Elsewhere, it has been demonstrated that aroma perception is implicated in the process of satiety (3). Co…