Search results for " anima"
showing 10 items of 3536 documents
Sleep restriction for the duration of a work week impairs multitasking performance
2010
It is important to develop shift schedules that minimise the chance for sleep-related human error in safety-critical domains. Experimental data on the effects of sleep restriction (SR) play a key role in this development work. In order to provide such data, we conducted an experiment in which cognitively demanding and long-duration task performance, simulating task performance at work, was measured under SR and following recovery. Twenty healthy male volunteers, aged 19-29 years, participated in the study. Thirteen of them had first two baseline days (8-h sleep opportunity per day), then five SR days (4-h sleep) and finally two recovery days (8-h sleep). Seven controls were allowed to sleep…
Cardiac Autonomic Activity during Sleep under the Influence of Radiofrequency Electromagnetic Fields. Autonome Herzaktivitat im Schlaf unter dem Einf…
2005
Question of the study We investigated the influence of radiofrequency electromagnetic fields emitted by digital mobile telephones on heart rate variability (HRV) during sleep in healthy young men.
Early developmental alterations of low-Mg2+ -induced epileptiform activity in the intact corticohippocampal formation of the newborn mouse in vitro.
2005
Abstract The generation, propagation and pharmacological properties of low-Mg 2+ -induced epileptiform activity were examined in the intact corticohippocampal formation (CHF) of the newborn (P0–4) mouse in vitro. Multi-site field potential recordings in dentate gyrus (DG), CA3, CA1, entorhinal cortex (EC) and temporal cortex (TC) revealed in 0.2 mM Mg 2+ -containing ACSF a stable pattern of spontaneous epileptiform activity consisting of recurrent ictal-like events (ILEs) and interictal events (IEs). Although this activity could be consistently observed as early as P0, ILEs were smaller in amplitude, less frequent and showed a slower onset in P0–2 as compared to P3–4 animals. In all age gro…
Alteration of the Calcium Content in Inner Hair Cells of the Cochlea of the Guinea Pig after Acute Noise Trauma with and without Application of the O…
1999
Calcium ions are known to be important to the process of signal transduction across the apical and basal sides of the inner hair cells. Calcium channel antagonists have been demonstrated by light microscopy to provide protection against acoustic trauma. To evaluate the protective effect of calcium channel blocker on the inner ear cells to noise exposure, the amount of the histochemical reaction products formed in the cytoplasm of the inner hair cells of the guinea pig after application of pyroantimonate was measured by an image processing system connected to an energy-filtering transmission electron microscope (EFTEM). Compared to untreated control specimens (experimental animal group I) th…
The extent of adhesion induction through electrocoagulation and suturing in an experimental rat study.
2008
Objective To investigate the effect of three types of peritoneal trauma occurring during surgery (high-frequency bipolar current, suturing, and mechanical damage) on postoperative adhesion formation in a rodent animal model. Design Randomized, controlled experimental trial in an in vitro animal model. Setting Laboratory facilities of a university department of obstetrics and gynecology. Animal(s) Thirty-five female Wistar rats. Intervention(s) Bilateral experimental lesions were created on the abdominal wall in every animal. The effect of minimal electrocoagulation was examined by creating lesions (n = 14) through sweeps of a bipolar forceps with a duration of 1 second and standardized pres…
Methotrexate-Loaded Polymethylmethacrylate Bone Cement for Local Bone Metastasis Therapy: Pilot Animal Study in the Rabbit Patellar Groove
2008
Local chemotherapy is an option in bone metastasis treatment. On the other hand, evaluation of side effects on bone is a difficult issue in drug development and biomaterials research. Most animal models to date are inappropriate or not feasible. Rabbits are an alternative to other bigger mammals and have an appropriate bone structure compared to rats and mice. The patellar groove model of the rabbit offers a standardized and sensitive model to evaluate bone-compromising drug effects. We tested the system with a reproducible polymethacrylate implant as carrier and loaded this system with methotrexate. Three methotrexate concentrations were used in the test samples (250 mg, 1 g and 4 g per 40…
Impact of single-dose application of TGF-β, copper peptide, stanozolol and ascorbic acid in hydrogel on midline laparatomy wound healing in a diabeti…
2012
Despite numerous advances and improvements in surgical techniques the incidence of incisional hernias after laparotomy remains high. The aim of this study was to investigate possible effects of single application of ascorbic acid, stanozolol, a synthetic anabolic steroid, copper peptide and transforming growth factor-β (TGF-β) on laparotomy wound healing in an incisional wound model in diabetic mice. After diabetes induction with streptozotozin in Balb-c mice, midline laparatomies were carried out. Closure of the linea alba was followed by single-dose application of the agents dissolved in a hydrogel before skin closure. The functional outcome was assessed in terms of maximum tensile streng…
Dilation of the ductus venosus by stent implantation increases placental blood perfusion in fetal sheep.
2006
The reduction of resistance to flow in the ductus venous (DV) and a decrease of blood supply to the liver serve for the survival of the fetus during hypoxia. The present study investigated the influence of the increased diameter of the DV on placental blood perfusion.In 15 ewes with twin pregnancies at gestational ages of 117 +/- 4 days, a stent (4 or 5 mm) was placed into the DV of 1 twin (DV(stent) group) under ultrasound guidance. Blood flow rates in the umbilical vein (UV) and DV of both fetuses were measured using Doppler ultrasound. Eight pairs of twin fetuses were included for the final analysis.The dilatation of the DV increased the blood flow volume rate passed through the DV from …
The sleep EEG's microstructure in depression: alterations of the phase relations between EEG rhythms during REM and NREM sleep
2002
Abstract Objective : We investigated the microstructure of sleep electroencephalograms (EEGs) of 13 unmedicated depressive inpatients and 13 healthy controls matched in sex and age, hypothesizing that depressives depict an alteration of certain EEG oscillations across the night. Methods : We digitized the sleep EEGs with a sampling rate of 100Hz (bipolar derivation C z –P z , 1440 single sweeps; 2048 data points each), calculated the time course of delta (1–3.5Hz), theta (3.5–7.5Hz), alpha (7.5–15Hz), and beta (15–35Hz) activity over the night, and determined the correlation coefficients of these different EEG rhythms separately for rapid eye movement (REM) and non-rapid eye movement (NREM)…
The histone acetyltransferase MOF activates hypothalamic polysialylation to prevent diet-induced obesity in mice
2014
Overfeeding causes rapid synaptic remodeling in hypothalamus feeding circuits. Polysialylation of cell surface molecules is a key step in this neuronal rewiring and allows normalization of food intake. Here we examined the role of hypothalamic polysialylation in the long-term maintenance of body weight, and deciphered the molecular sequence underlying its nutritional regulation. We found that upon high fat diet (HFD), reduced hypothalamic polysialylation exacerbated the diet-induced obese phenotype in mice. Upon HFD, the histone acetyltransferase MOF was rapidly recruited on the St8sia4 polysialyltransferase-encoding gene. Mof silencing in the mediobasal hypothalamus of adult mice prevented…