Search results for " antibiotic."
showing 10 items of 142 documents
New antimicrobial peptides from Tirmania pinoyi and Terfezia boudieri in the struggle against antibiotic resistance
2017
Antibiotic resistance of common pathogenic microorganisms is a topic of great concern that has finally received media attention and entered into the political agenda of world leaders. Drug-resistant bacteria are cause of thousands of deaths worldwide, then there is an urgent need for new antimicrobials, otherwise we risk losing the ability to control effectively the infectious diseases. Such emergence can be faced looking also at not usual source of antimicrobial agents, for example medicinal mushrooms. With the objective to tackle Gram-positive and Gram-negative pathogens, we focused on two edible desert truffles mushrooms Tirmania pinoyi and Terfezia boudieri as origin of new antimicrobia…
"Flora e fauna antartica di interesse biotecnologico: esperienze e future prospettive in Italia ed Argentina"
2017
In Antartide sono presenti estreme condizioni ambientali e, fra i viventi, alcuni batteri, recentemente descritti da studiosi italiani, aventi la caratteristica di produrre molecole antibiotico-simili utili a curare soggetti affetti da fibrosi cistica. Studi condotti da esperti argentini e di altri paesi hanno portato alla scoperta di comunità batteriche con grosso potenziale biotecnologico sfruttabile nell’industria alimentare, tessile, dei biocarburanti ed anche utili come degradatori di idrocarburi da usare in protocolli di ripristino di suoli contaminati; anche lieviti e virus antartici sono di interesse biotecnologico. In conclusione l’Antartide è una miniera ecosostenibile di risorse …
Phosphate control of balhimycin biosynthesis in Amycolatopsis balhimycina
2008
The occurrence of extended-spectrum β-lactamase producing Shigella spp. in Tehran, Iran
2013
Background and Objectives: The emergence of extended-spectrum β-lactamase (ESBL)-producing Shigella spp. is of increasing clinical concern specially in children worldwide. The aim of this study was to investigate the occurrence of extended-spectrum β-lactamase producing Shigella spp. in Tehran, Iran. Materials and Methods: The study included all Shigella isolates recovered from pediatric patients aged less than 12 years admitted to a major pediatric hospital in Tehran, Iran, from 2008 to 2010. Bacterial identification, antimicrobial susceptibility testing, extended spectrum β-lactamases (ESBLs) screening and confirmatory tests were performed according to the standard guidelines. Conjugal tr…
The role of a monthly active surveillance programme for multidrug-resistant Gram-negative bacteria in a neonatal intensive care unit: impact evaluati…
2020
Background: Antimicrobial resistance is a public health threat. Neonatal Intensive Care Unit (NICU) patients are particularly at risk, due to the large use of invasive devices and antimicrobial treatment. Since 2014 an active surveillance program of multidrug-resistant organisms is in place in the five NICUs of Palermo, Italy. High prevalence of multidrug-resistant Gram-negative bacteria (MDR-GNB) carriage observed in one NICU suggested the need of a long-lasting approach to achieve effective control of MDR-GNB circulation. Materials/methods: Rectal swabs were obtained every month from each hospitalized new-born. Samples were enriched in liquid cultures, plated in McConkey Agar with three a…
La bilicultura un'utile guida per la terapia antibiotica nella chirurgia delle vie biliari
1978
THE SMALL PROTEIN TRPM MODULATES MORPHO-PHYSIOLOGICAL DIFFERENTIATION IN THE MODEL ACTINOMYCETE STREPTOMYCES COELICOLOR A3(2)
2017
BACKGROUNDS TrpM, a small protein of 63 amino acids, modulates tryptophan (Trp) metabolism and morpho-physiological differentiation in the filamentous bacterium Streptomyces coelicolor A3(2), a model organism for antibiotic production and cell differentiation. Indeed, the trpM knock-out mutant strain is characterized by a delayed growth on minimal medium, smaller aerial hyphae, and reduction of both spore and antibiotic actinorhodin production in comparison with the wild-type strain. These observations were in agreement with proteomic analyses which highlighted a role for TrpM in controlling i) Trp production through Trp precursor availability and, thus ii) bacterial growth and morpho-physi…
The small protein TrpM modulates morpho-physiological differentiation in Streptomyces coelicolor
2017
TrpM, a small protein of 63 amino acids, is encoded by a gene of the trpCMBA locus involved in tryptophan biosynthesis in the model actinomycete Streptomyces coelicolor. Indeed, the trpM knock-out mutant strain is characterized by a delayed growth on minimal medium, smaller aerial hyphae, and reduction of both spore and antibiotic actinorhodin production in comparison with the wild-type strain. These observations are in agreement with proteomic analyses which highlighted a role for TrpM in controlling i) tryptophan production through precursor availability and, thus ii) bacterial growth and morpho-physiological differentiation. To further elucidate the role of TrpM, a S. coelicolor trpM kno…
A small protein is involved in tryptophan biosynthesis and morpho-physiological differentiation in Streptomyces coelicolor
2015
A small protein is involved in tryptophan biosynthesis and morpho-physiological differentiation in Streptomyces coelicolor