Search results for " applications."
showing 10 items of 4344 documents
Molecular Approaches Fighting Nonsense
2021
Nonsense mutations are the result of single nucleotide substitutions in the DNA that change a sense codon (coding for an amino acid) to a nonsense or premature termination codon (PTC) within the coding region of the mRNA [...]
The Role of the α Cell in the Pathogenesis of Diabetes: A World beyond the Mirror
2021
Type 2 Diabetes Mellitus (T2DM) is one of the most prevalent chronic metabolic disorders, and insulin has been placed at the epicentre of its pathophysiological basis. However, the involvement of impaired alpha (α) cell function has been recognized as playing an essential role in several diseases, since hyperglucagonemia has been evidenced in both Type 1 and T2DM. This phenomenon has been attributed to intra-islet defects, like modifications in pancreatic α cell mass or dysfunction in glucagon’s secretion. Emerging evidence has shown that chronic hyperglycaemia provokes changes in the Langerhans’ islets cytoarchitecture, including α cell hyperplasia, pancreatic beta (β) cell dedifferentiati…
miR-31-5p Is a LIPUS-Mechanosensitive MicroRNA that Targets HIF-1α Signaling and Cytoskeletal Proteins
2019
The roles of low-intensity pulsed ultrasound (LIPUS) and microRNAs (miRNAs) on hMSCs commitments have already been investigated
Autoimmune thyroid disease: new models of cell death in autoimmunity
2002
Autoimmunity to thyroid antigens leads to two distinct pathogenic processes with opposing clinical outcomes: hypothyroidism in Hashimoto's thyroiditis and hyperthyroidism in Graves' disease. The high frequency of these diseases and easy accessibility of the thyroid gland has allowed the identification of key pathogenic mechanisms in organ-specific autoimmune diseases. In early investigations, antibody- and T-cell-mediated death mechanisms were proposed as being responsible for autoimmune thyrocyte depletion. Later, studies on apoptosis have provided new insights into autoimmune target destruction, indicating the involvement of death receptors and cytokine-regulated apoptotic pathways in the…
Standardization of islet isolation outcome- A new automatic system to determine pancreatic islet viability
2011
Pancreatic islet transplantation is emerging as a therapeutic approach for patients affected by diabetes. This approach consists of a minimally invasive procedure replacing insulin-producing cells (pancreatic islets). The technique has been proven successful, but limitations have been identified. One of the major challenges of the procedure is the counting of the isolated pancreatic islets, which is currently jeopardized by subjectivity and inaccuracy. Determination of the accurate islet number is a crucial factor in determining the correlation between the isolation product and clinical outcome. In the proposed study, we have developed software capable of objectively evaluating islet number…
Interplay Between MicroRNAs and Oxidative Stress in Ovarian Conditions with a Focus on Ovarian Cancer and Endometriosis
2019
Ovarian cancer and endometriosis are two distinct gynaecological conditions that share many biological aspects incuding proliferation, invasion of surrounding tissue, inflammation, inhibition of apoptosis, deregulation of angiogenesis and the ability to spread at a distance. miRNAs are small non-coding RNAs (19–22 nt) that act as post-transcriptional modulators of gene expression and are involved in several of the aforementioned processes. In addition, a growing body of evidence supports the contribution of oxidative stress (OS) to these gynaecological diseases: increased peritoneal OS due to the decomposition of retrograde menstruation blood facilitates both endometriotic lesion developmen…
Collaborative Mobile Clouds: An Energy Efficient Paradigm for Content Sharing
2018
On the way toward enabling efficient content distribution, reducing energy consumption and prolonging battery life of mobile equipment, an emerging paradigm, i.e., mobile cloud, which is based on content distribution, was proposed. As a mobile platform that is oriented toward content distribution, mobile cloud is also foreseen as an energy-efficient solution for future wireless networks. The benefits of using CMC for content distribution or distributed computing from social networking perspectives have been studied earlier. In this article, we first present the concepts of CMC and then discuss the energy-efficiency benefits from the system-level point-of-view as well as open challenges in d…
Autonomy and responsibility as key values for the elaboration of rules of coexistence in the ESO
2012
Algunas de las cuestiones que se plantean en el artículo son las siguientes: ¿Son los alumnos capaces de organizar el comportamiento y la convivencia en el aula? ¿Están capacitados para elaborar sus propias normas? o ¿Solamente se trata de un planteamiento teórico que resulta inviable de llevar a la práctica? En todo caso, ¿Qué nivel de responsabilidad y autonomía pueden asumir en el funcionamiento del aula? El aprendizaje de normas en el aula constituye una experiencia real, muy próxima a la experiencia y los intereses de los alumnos, que permite trabajar valores como la responsabilidad, el respeto, la participación, el diálogo y la democracia. A su vez les enseña a participar en asambleas…
Multimodal Communication and Peer Interaction during Equation-Solving Sessions with and without Tangible Technologies
2023
Despite the increasing use of technologies in the classroom, there are concerns that technology-enhanced learning environments may hinder students’ communication and interaction. In this study, we investigated how tangible technologies can enhance students’ multimodal communication and interaction during equation-solving pair work compared to working without such technologies. A tangible app for learning equation solving was developed and tested in fourth and fifth-grade classrooms with two class teachers and 24 students. Video data of the interventions were analysed using deductive and inductive content analysis. Coded data were also quantified for quantitative analysis. Additionally, teac…
A Survey of Some Arithmetic Applications of Ergodic Theory in Negative Curvature
2017
This paper is a survey of some arithmetic applications of techniques in the geometry and ergodic theory of negatively curved Riemannian manifolds, focusing on the joint works of the authors. We describe Diophantine approximation results of real numbers by quadratic irrational ones, and we discuss various results on the equidistribution in \(\mathbb{R}\), \(\mathbb{C}\) and in the Heisenberg groups of arithmetically defined points. We explain how these results are consequences of equidistribution and counting properties of common perpendiculars between locally convex subsets in negatively curved orbifolds, proven using dynamical and ergodic properties of their geodesic flows. This exposition…