Search results for " array"
showing 10 items of 895 documents
The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity.
2007
Epithelial to mesenchymal transition (EMT) is implicated in the progression of primary tumours towards metastasis and is likely caused by a pathological activation of transcription factors regulating EMT in embryonic development. To analyse EMT-causing pathways in tumouri-genesis, we identified transcriptional targets of the E-cadherin repressor ZEB1 in invasive human cancer cells. We show that ZEB1 repressed multiple key determinants of epithelial differentiation and cell–cell adhesion, including the cell polarity genes Crumbs3, HUGL2 and Pals1-associated tight junction protein. ZEB1 associated with their endogenous promoters in vivo, and strongly repressed promotor activities in reporter …
Cascades of transcriptional induction during dendritic cell maturation revealed by genome-wide expression analysis.
2003
Dendritic cells (DC) are central regulators of immunity. Signal-induced maturation of DCs is assumed to be the starting point for specific immune responses. To further understand this process, we analyzed the alteration of transcript profiles along the time course of CD40 ligand-induced maturation of human myeloid DCs by Affymetrix GeneChip microarrays covering >6800 genes. Besides rediscovery of genes already described as associated with DC maturation proving reliability of the methods used, we identified clusterin as novel maturation marker. Looking across the time course, we observed synchronized kinetics of distinct functional groups of molecules whose temporal coregulation underscores …
Monitoring of chicken meat freshness by means of a colorimetric sensor array
2012
A new optoelectronic nose to monitor chicken meat ageing has been developed. It is based on 16 pigments prepared by the incorporation of different dyes (pH indicators, Lewis acids, hydrogenbonding derivatives, selective probes and natural dyes) into inorganic materials (UVM-7, silica and alumina). The colour changes of the sensor array were characteristic of chicken ageing in a modi¿ed packaging atmosphere (30% CO2¿70% N2). The chromogenic array data were processed with qualitative (PCA) and quantitative (PLS) tools. The PCA statistical analysis showed a high degree of dispersion, with nine dimensions required to explain 95% of variance. Despite this high dimensionality, a tridimensional re…
γ-ray linear polarization measurements and(g9/2)−3neutron alignment in91Ru
2013
The authors would like to thank the operators of the GANIL cyclotrons for providing the 36Ar beam. We would also like to thank the EXOGAM Collaboration for use of the clover Ge detector array, the DIAMANT Collaboration for use of the charged particle detector system, and the European gamma-ray Spectroscopy Pool for use of the neutron detector system. We acknowledge funding support from the French-Polish LEA COPIGAL and the IN2P3-Polish laboratories COPIN Agreement No. 06-122, from the UK STFC, from the Swedish Research Council (Contracts No. 2007-4067 and No. 2008-5793), from the Goran Gustafsson Foundation, from the OTKA under Contract No. K100835, and from the Bolyai Janos Foundation. AG …
A Novel Bio-Inspired Approach for High-Performance Management in Service-Oriented Networks
2021
Service-continuity in distributed computing can be enhanced by designing self-organized systems, with a non-fixed structure, able to modify their structure and organization, as well as adaptively react to internal and external environment changes. In this paper, an architecture exploiting a bio-inspired management approach, i.e., the functioning of cell metabolism, for specialized computing environments in Service-Oriented Networks (SONs) is proposed. Similar to the processes acting in metabolic networks, the nodes communicate to each other by means of stimulation or suppression chains giving rise to emergent behaviors to defend against foreign invaders, attacks, and malfunctioning. The mai…
Mobile Wireless Interfaces: In Search for the Limits
2002
With the proliferation of 2G and 3G Telecom and other wireless networks hundred of millions of users will be able to access wireless services with their terminals in only a few years. In this paper we discuss the possibilities and limitations of existing and emerging mobile technologies and methodologies for porting information and functionality from traditional PCs to mobile devices and vice versa. We argue that in order to be able to properly port things between devices an equivalence concept for user interfaces is required.
A novel digital control for DC/DC converters to improve steady-state performances
2006
This paper describes an innovative digital PWM control implementation for low voltage, high current DC-DC converters. The proposed technique, based on the use of a low resolution DAC, improves steady-state performances, minimizing limit cycle effects. The novel technique is tested on a FPGA-based single phase buck converter operating at 250 kHz. A detailed description of the proposed architecture is given and test results, simulation and experimental ones, are shown
Variable delay line for phased-array antenna based on a chirped fiber grating
2000
We present a theoretical and experimental analysis of the performance of phased-array antennas steered by a single chirped fiber grating. Two approaches consisting of conventional and single-sideband (SSB) modulation techniques of the optical signal are presented in order to compare their performance and suitability for beamforming applications in microwave antennas. By using a 40-cm-long chirped grating, we measure the phase and amplitude response and calculate the corresponding radiation patterns to demonstrate wide-band operation and continuous spatial scanning properties of both configurations. SSB modulation Is presented as a real alternative to the first one offering broader operation…
Changes in gene expression linked with adult reproductive diapause in a northern malt fly species: a candidate gene microarray study
2010
Abstract Background Insect diapause is an important biological process which involves many life-history parameters important for survival and reproductive fitness at both individual and population level. Drosophila montana, a species of D. virilis group, has a profound photoperiodic reproductive diapause that enables the adult flies to survive through the harsh winter conditions of high latitudes and altitudes. We created a custom-made microarray for D. montana with 101 genes known to affect traits important in diapause, photoperiodism, reproductive behaviour, circadian clock and stress tolerance in model Drosophila species. This array gave us a chance to filter out genes showing expression…
Fabrication of Electrical Contacts on Pyramid-Shaped NTD-Ge Microcalorimeters Using Free-Standing Shadow Masks
2011
In our effort to fabricate arrays of germanium microcalorimeters for X-ray detection, a truncated square-based pyramid shape has been identified as a suitable geometry for the sensors. It allows to obtain a uniform current spreading across each sensor, and represents a good compromise between having a large support area for the radiation absorber and for maintaining an overall small bolometer volume. This three-dimensional geometry, however, does not allow to create the electrical contacts for the sensors using a regular photoresist-based lift-off metallization process. In this paper we show how to deposit metal contacts on the lateral faces of the pyramidal sensors by metal evaporation thr…