Search results for " array"

Genetic and Molecular Characterization of The Human Osteosarcoma 3AB-OS Cancer Stem Cell Line: A Possible Model For Studying Osteosarcoma Origin and …

2013

Finding new treatments targeting cancer stem cells (CSCs) within a tumor seems to be critical to halt cancer and improve patient survival. Osteosarcoma is an aggressive tumor affecting adolescents, for which there is no second-line chemotherapy. Uncovering new molecular mechanisms underlying the development of osteosarcoma and origin of CSCs is crucial to identify new possible therapeutic strategies. Here, we aimed to characterize genetically and molecularly the human osteosarcoma 3AB-OS CSC line, previously selected from MG63 cells and which proved to have both in vitro and in vivo features of CSCs. Classic cytogenetic studies demonstrated that 3AB-OS cells have hypertriploid karyotype wit…

A hardware skin-segmentation IP for vision based smart ADAS through an FPGA prototyping

2017

International audience; In this paper we presents a platform based design approach for fast HW/SW embedded smart Advanced Driver Assistant System (ADAS) design and prototyping. Then, we share our experience in designing and prototyping a HW/SW vision based smart embedded system as an ADAS that helps to increase the safety of car's drivers. We present a physical prototype of the vision ADAS based on a Zynq FPGA. The system detects the fatigue state of the driver by monitoring the eyes closure and generates a real-time alert. A new HW/SW codesign skin segmentation step to locate the eyes/face is proposed. Our presented new approach migrates the skin segmentation step from processing system (S…

Computational cluster validation for microarray data analysis: experimental assessment of Clest, Consensus Clustering, Figure of Merit, Gap Statistic…

2008

Abstract Background Inferring cluster structure in microarray datasets is a fundamental task for the so-called -omic sciences. It is also a fundamental question in Statistics, Data Analysis and Classification, in particular with regard to the prediction of the number of clusters in a dataset, usually established via internal validation measures. Despite the wealth of internal measures available in the literature, new ones have been recently proposed, some of them specifically for microarray data. Results We consider five such measures: Clest, Consensus (Consensus Clustering), FOM (Figure of Merit), Gap (Gap Statistics) and ME (Model Explorer), in addition to the classic WCSS (Within Cluster…

A High speed data link optimization for digitalized transfer to processing FPGA

2021

State-of-the-art arrays of detectors, that require digital processing, may have a sizeable number of digitalized signal links. This is the case in several experimental nuclear physics instruments. Moreover, the data rate of the sampled signals, defined primary by the signal bandwidth of the individual detectors, may not exhaust the capabilities of a single FPGA transceiver input. The preprocessing is usually carried out in a modern FPGA with transceiver data rate capabilities over 10Gbps. Moreover, cost effective FPGA have a limited number of transceivers for given FPGA processing capabilities. The investigation of a cost-effective and efficient solution to the mismatch between both data ra…

Riarrangiamento complesso di un cromsoma X identificato mediante arrayCGH in un soggetto con cariotipo a mosaico e grave ritardo mentale

2009

12q21 Interstitial Deletions: Seven New Syndromic Cases Detected by Array-CGH and Review of the Literature.

2022

Interstitial deletions of the long arm of chromosome 12 are rare, with a dozen patients carrying a deletion in 12q21 being reported. Recently a critical region (CR) has been delimited and could be responsible for the more commonly described clinical features, such as developmental delay/intellectual disability, congenital genitourinary and brain malformations. Other, less frequent, clinical signs do not seem to be correlated to the proposed CR. We present seven new patients harboring non-recurrent deletions ranging from 1 to 18.5 Mb differentially scattered across 12q21. Alongside more common clinical signs, some patients have rarer features such as heart defects, hearing loss, hypotonia an…

Application of Electronic Nose for Evaluation of Wastewater Treatment Process Effects at Full-Scale WWTP

2019

This paper presents the results of studies aiming at the assessment and classification of wastewater using an electronic nose. During the experiment, an attempt was made to classify the medium based on an analysis of signals from a gas sensor array, the intensity of which depended on the levels of volatile compounds in the headspace gas mixture above the wastewater table. The research involved samples collected from the mechanical and biological treatment devices of a full-scale wastewater treatment plant (WWTP), as well as wastewater analysis. The measurements were carried out with a metal-oxide-semiconductor (MOS) gas sensor array, when coupled with a computing unit (e.g., a computer with…

A multi-input, single-inductor power system for multisource energy harvesting

2013

Today, energy harvesting is drawing a great deal of attention due to modern trends in energy saving and sustainable development purposes. Among renewable energy sources fuel cells and photovoltaic arrays are the most promising for a wide variety of applications, ranging from few mWatts of wireless sensor networks to kWatts for household appliances. Coupling several harvesters and renewable sources is the winning strategy to ensure a proper supply overcoming the uncertainty and limited availability of common harvesters and renewable sources. Multisource energy harvesting is actually an open research topic involving several pressing and often conflicting requirements. System cost, complexity,…

FPGA-based Acceleration of Detecting Statistical Epistasis in GWAS

2014

Abstract Genotype-by-genotype interactions (epistasis) are believed to be a significant source of unexplained genetic variation causing complex chronic diseases but have been ignored in genome-wide association studies (GWAS) due to the computational burden of analysis. In this work we show how to benefit from FPGA technology for highly parallel creation of contingency tables in a systolic chain with a subsequent statistical test. We present the implementation for the FPGA-based hardware platform RIVYERA S6-LX150 containing 128 Xilinx Spartan6-LX150 FPGAs. For performance evaluation we compare against the method iLOCi[9]. iLOCi claims to outperform other available tools in terms of accuracy.…

FLUMO: FLexible Underwater MOdem

2019

The last years have seen a growing interest in underwater acoustic communications because of its applications in marine research, oceanography, marine commercial operations, the offshore oil industry and defense. High-speed communication in the underwater acoustic channel has been challenging because of limited bandwidth, extended multipath, refractive properties of the medium, severe fading, rapid time variation and large Doppler shifts. In this paper, we show an implementation of a flexible Software-Defined Acoustic (SDA) underwater modem, where modulation parameters are completely tunable to optimize performance. In particular, we develop the system architecture following two key ideas. …