Search results for " assembly"

Recognition-Directed Supramolecular Assemblies of Metal Complexes of Terpyridine Derived Ligands with Self-Complementary Hydrogen Bonding Sites

2000

The synthesis and X-ray structures of three metal complexes with terpyridine-derived ligands that contain amino-pyrimidine and amino-pyrazine moieties are presented. They have been designed in view of directing their self-assembly into specific supramolecular arrays through molecular recognition interactions. The solid-state structures indeed reveal extensive hydrogen-bonded networks. The Co complex 4a with PF6- counterions builds a two-dimensional infinite interwoven grid through strong double hydrogen bonds (d(N-H-N) =2.918-3.018 A) between the amino groups and the N atoms of the rings, with all H-bonding sites saturated. Changing the anions to BF4- in 4b leads to a similar infinite but p…

The United Nations child policy : international games of morality and power

2013

Epigenetic involvement in Hutchinson-Gilford progeria syndrome: a mini-review.

2013

Hutchinson-Gilford progeria syndrome (HGPS) is a rare human genetic disease that leads to a severe premature ageing phenotype, caused by mutations in the <i>LMNA</i> gene. The <i>LMNA</i> gene codes for lamin-A and lamin-C proteins, which are structural components of the nuclear lamina. HGPS is usually caused by a de novo <i>C1824T</i> mutation that leads to the accumulation of a dominant negative form of lamin-A called progerin. Progerin also accumulates physiologically in normal ageing cells as a rare splicing form of lamin-A transcripts. From this perspective, HGPS cells seem to be good candidates for the study of the physiological mechanisms of ageing…

Due democratiche cristiane alla Consulta nazionale: Laura Bianchini e Angela Maria Guidi Cingolani

2022

Questo articolo appartiene a uno studio più ampio che mira a ricostruire una tradizione politica femminile per comprendere alcune delle ragioni persistenti dietro il divario di genere tra accesso formale e sostanziale alle decisioni. L’obiettivo finale è quello di evidenziare il ruolo e il contributo delle donne, soprattutto di quelle che sono finite nell’oblio, nella costituzione di un’Italia democratica e repubblicana fin dalle loro prime partecipazioni all’Assemblea Nazionale Consultiva. L’Archivio della Camera dei Deputati, l’Archivio dell’Istituto Sturzo e gli articoli delle riviste dell’epoca sono state le fonti primarie della ricerca.Il 25 settembre 1945 si inaugura la Consulta che r…

Thermus bacteriophage P23-77 : key member of a novel, but ancient family of viruses from extreme environments

2015

Arsenite-induced aneuploidy following short and long-term exposure in mammalian cells

2009

We studied the long-term progression of chromosomal instability in V79 cells treated acutely with arsenite (10mM, 24 hr) followed by growth in arsenic-free medium for 120 cell generations. Indirect immunostaining using anti-ß-tubulin antibody showed severe alterations in spindle morphology after only 6 h treatment and cytogenetic investigations carried out at the end of treatment revealed that the percentage of cells with 21 chromosomes (modal number of the cell line) decreased, making way for aneuploid cells. The acquired instability remained and propagated within the cell population. Moreover, we treated V79-derived G12 cells with sub-lethal doses (0.1-1.0 μM) of arsenite for 10 days foll…

Genetics of familial hypobetalipoproteinemia

2007

Primary hypobetalipoproteinemias include three monogenic disorders: the relatively frequent codominant familial hypobetalipoproteinemia (FHBL), the rare recessive conditions abetalipoproteinemia (ABL) and chylomicron retention disease (CMRD). Approximately 50% of FHBL patients are carriers of mutations in the APOB gene, mostly causing the formation of truncated forms of ApoB. In some kindred, FHBL is linked to a locus on chromosome 3 (3p21), but the candidate gene is still unknown. Recently, a FHBL-like phenotype was observed in carriers of mutations of the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene causing loss-of-function of the encoded protein, a proprotein convertase tha…

Metal ions modulate thermal aggregation of betalactoglobulin: a join chemical and physical characterization

2014

Abstract Molecular basis of the role played by Cu 2 + and Zn 2 + ions during the thermal aggregation processes of beta-lactoglobulin (BLG) was studied by using a joint application of different techniques. In particular, Raman spectroscopy was very useful in identifying the different effects caused by the two metals at molecular level (i.e. changes in His protonation state, disulfides bridge conformation, and micro-environment of aromatic residues), evidencing the primary importance of the protein charge distribution during the aggregation process. Both metal ions are able to act on this factor and favor the protein aggregation, but Zn 2 + is able to alter the natural conformational state of…

A Lost Opportunity to Parliamentarize The European Commission : Bagehot, Weber and a Debate in 1960

2022

The article emphasizes the significance of EU studies for political thought and concepts. It deals with the seemingly technical topic of the membership of cabinet ministers in parliament. This practice arose in eighteenth-century Westminster and has been discussed since the mid-nineteenth century, Walter Bagehot's and Max Weber's writings being landmarks. When the European Parliamentary Assembly in 1960 interpreted the Treaty of Rome, it took the view, by a narrow margin, that membership of the Parliament was incompatible with membership of the Commission. The debate on the compatibility of dual membership could have been a way to promote the parliamentarization of the EU. peerReviewed

Studies of two-dimensional and three-dimensional phononic crystal structures

2016

This thesis focuses on studying phononic crystal structures. More specifically, it is aimed at fabrication and measurement of thermal properties of two-dimensional (2D) periodic microstructures and three-dimensional (3D) nanostructures. There is great interest in understanding, manipulating and considering application perspective of minimizing of thermal transport in periodic structures. Periodic structures have been studied more on their optical properties, but this thesis places emphasis on their application of manipulating heat. A process of fabricating two-dimensional hole array phononic (2D PnC) structures is described here. It consists of membrane preparation, superconductor-insulator…