Search results for " bank"

showing 10 items of 502 documents

Prospective computational design and in vitro bio-analytical tests of new chemical entities as potential selective CYP17A1 lyase inhibitors

2019

[EN] The development and advancement of prostate cancer (PCa) into stage 4, where it metastasize, is a major problem mostly in elder males. The growth of PCa cells is stirred up by androgens and androgen receptor (AR). Therefore, therapeutic strategies such as blocking androgens synthesis and inhibiting AR binding have been explored in recent years. However, recently approved drugs (or in clinical phase) failed in improving the expected survival rates for this metastatic-castration resistant prostate cancer (mCRPC) patients. The selective CYP17A1 inhibition of 17,20-lyase route has emerged as a novel strategy. Such inhibition blocks the production of androgens everywhere they are found in t…

Quantitative structure–activity relationshipStereochemistry01 natural sciencesBiochemistryStructure-Activity Relationship3D-QSAR pharmacophore modelDrug DiscoveryCytochrome P-450 Enzyme InhibitorsHumansStructure–activity relationshipCYP17A1 InhibitorMolecular BiologyDensity Functional TheoryVirtual screeningDose-Response Relationship DrugMolecular Structure010405 organic chemistryChemistryOrganic ChemistryProspective computational designSteroid 17-alpha-Hydroxylasecomputer.file_format1720-lyase selective inhibitionProtein Data BankLyase0104 chemical sciencesMolecular Docking Simulation010404 medicinal & biomolecular chemistryDocking (molecular)CYP17A1 inhibitorsMetastatic-castration resistant prostate cancerPharmacophorecomputer
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Cost-Effectiveness Analysis of Different Testing Strategies that Use Antibody Levels to Detect Chronic Hepatitis C in Blood Donors.

2016

Aim. We conducted a cost-effectiveness analysis of seven hepatitis C virus (HCV) testing strategies in blood donors. Methods. Three of the seven strategies were based on HCV diagnosis and reporting guidelines in Mexico and four were from previous and current recommendations outlined by the CDC. The strategies that were evaluated determine antibody levels according to the signal-to-cut-off (S/CO) ratio and use reflex Immunoblot (IMB) or HCV RNA tests to confirm true positive (TP) cases of chronic HCV infection. Costs were calculated from the perspective of the Mexican Institute of Social Security (IMSS). A decision tree model was developed to estimate the expected number of true positive cas…

RNA virusesDecision AnalysisPhysiologyEconomicsCost-Benefit AnalysisSocial Scienceslcsh:MedicineBlood DonorsHepacivirusmedicine.disease_causeBiochemistryHepatitis0302 clinical medicineImmune Physiology030212 general & internal medicineChroniclcsh:SciencePathology and laboratory medicinehealth care economics and organizationsMultidisciplinaryImmune System ProteinsCost–benefit analysisHepatitis C virusLiver DiseaseCost-effectiveness analysisMedical microbiologyHepatitis CHCV AntibodyInfectious DiseasesVirusesEngineering and TechnologyBlood Banks030211 gastroenterology & hepatologyPathogensInfectionManagement EngineeringResearch Articlemedicine.medical_specialtyGeneral Science & TechnologyHepatitis C virusImmunologyCost-Effectiveness AnalysisImmunoblottingChronic Liver Disease and CirrhosisMolecular Probe TechniquesAntibody levelResearch and Analysis MethodsMicrobiologyAntibodies03 medical and health sciencesChronic hepatitisHepatitis - CClinical ResearchInternal medicineparasitic diseasesmedicineHumansImmunoassaysMolecular Biology TechniquesSensitivity analysesMolecular BiologyMedicine and health sciencesBiology and life sciencesFlavivirusesbusiness.industryDecision Treeslcsh:RHepatitis C antibodyOrganismsViral pathogensProteinsHepatitis C ChronicHepatitis C AntibodiesHepatitis virusesEconomic AnalysisMicrobial pathogensHealth CareEmerging Infectious DiseasesCost Effectiveness ResearchHealth Care FacilitiesImmunologyImmunologic Techniqueslcsh:QbusinessDigestive Diseases
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Le réalisme social américain à l'ère postmoderne : (Russell Banks, Raymond Carver, Richard Ford)

2012

His study focuses on the works of Russell Banks, Raymond Carver and Richard Ford. They started writing during the 1960s and 1970s, at a time when the self-reflexivity and metafictional play of postmodernist writers were drawing a lot of critical attention in academic circles. However, they consider themselves to be realist writers. In “A Few Words about Minimalism,” John Barth suggested that the return to realist fiction in the mid-1970s could be both a reaction against so-called “postmodernist” fiction and a symptom of the social and economic unease of the period. Indeed, Cathedral, Continental Drift and The Sportswriter describe in accurate detail the everyday lives of ordinary American m…

Raymond CarverLittérature américaineAmerican literature20th centuryRealismCriticism and interpretationPostmodernismeRéalismeLiterary conventionsConventions littéraires[SHS]Humanities and Social Sciences[SHS.LITT] Humanities and Social Sciences/LiteratureRichard FordCritique et interprétation20ème sièclePostmodernismArtifice[SHS] Humanities and Social SciencesRussell BanksComputingMilieux_MISCELLANEOUS
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AS "Citadele Banka" reklāmas kampaņu atbilstība patērētāju vēlmēm

2019

Latvijas bankas tirgū novērojama liela konkurence, tāpēc darba autors izvēlējies aplūkot vienas bankas izvietotās reklāmas, izvērtēt to efektivitāti un dot priekšlikumus potenciālai konkurētspējas uzlabošanai. Darba teorētiskajā daļā aplūkota reklāmu nozīme un būtība, sīkāk apskatīts, kādi ir galvenie reklāmu mērķi, to iedalījums pēc reklāmas veidiem kā arī reklāmu efektivitātes veicināšanas veidu aplūkošana. Analītiskajā daļā aplūkota uzņēmuma AS “Citadele Banka” vēsture, organizatoriskā struktūra kā arī izpētīts uzņēmuma produkta klāsts, finanšu rādītāji un uzņēmuma misija, vīzija un mērķi. Pētnieciskajā daļā analizētas Citadeles bankas izvietotās produkta “X karte” bezkontaktu norēķinu k…

Reklāmas izplatīšanas kanāliReklāmas efektivitāteEkonomikaCitadele BankaX Karte
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RepeatsDB in 2021: improved data and extended classification for protein tandem repeat structures

2020

The RepeatsDB database (URL: https://repeatsdb.org/) provides annotations and classification for protein tandem repeat structures from the Protein Data Bank (PDB). Protein tandem repeats are ubiquitous in all branches of the tree of life. The accumulation of solved repeat structures provides new possibilities for classification and detection, but also increasing the need for annotation. Here we present RepeatsDB 3.0, which addresses these challenges and presents an extended classification scheme. The major conceptual change compared to the previous version is the hierarchical classification combining top levels based solely on structural similarity (Class > Topology > Fold) with two new lev…

Repetitive Sequences Amino AcidAcademicSubjects/SCI00010BiologíaStatistics as TopicProtein Data Bank (RCSB PDB)Computational biologyBiologyRepetitive SequencesGene Ontology; HEK293 Cells; HeLa Cells; Humans; Proteins; Reproducibility of Results; Statistics as Topic; User-Computer Interface; Databases Protein; Repetitive Sequences Amino Acid; Tandem Repeat SequencesDatabases03 medical and health sciencesAnnotationUser-Computer InterfaceProtein structureSimilarity (network science)Tandem repeatGeneticsDatabase IssueHumansDatabases ProteinCiencias Exactasdatabase030304 developmental biology0303 health sciencesHierarchy (mathematics)Protein030302 biochemistry & molecular biologyProteinsReproducibility of Resultscomputer.file_formatProtein Data BankClass (biology)proteinsAmino AcidComputingMethodologies_PATTERNRECOGNITIONGene OntologyHEK293 CellsclassificationTandem Repeat Sequencesprotein tandem repeat structures[INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM]computerHeLa CellsNucleic Acids Research
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Reporting of Intellectual Capital: evidence from the Italian Banking Sector

2014

The transition from an economy based on production towards a knowledge-based economy has highlighted the crucial role of Intellectual Capital (IC) in the firm’s financial performance. Intellectual Capital is a business resource that includes know-how, patents, internal and external relationships. IC is widely acknowledged as one of the most critical resources which organizations rely on to improve their efficacy and efficiency, and hence help to improve the value creation and competitive advantage (de Pablos, 2003). There are several empirical studies that examined the quantity and the nature of IC information disclosure in annual reports in different industries and countries (Guthrie and P…

ReportingIntellectual capitalItalian banking sectorDisclosure
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Contribution of 30 biomarkers to 10-year cardiovascular risk estimation in 2 population cohorts: the MONICA, risk, genetics, archiving, and monograph…

2010

Background— Cardiovascular risk estimation by novel biomarkers needs assessment in disease-free population cohorts, followed up for incident cardiovascular events, assaying the serum and plasma archived at baseline. We report results from 2 cohorts in such a continuing study. Methods and Results— Thirty novel biomarkers from different pathophysiological pathways were evaluated in 7915 men and women of the FINRISK97 population cohort with 538 incident cardiovascular events at 10 years (fatal or nonfatal coronary or stroke events), from which a biomarker score was developed and then validated in the 2551 men of the Belfast Prospective Epidemiological Study of Myocardial Infarction (PRIME) co…

Risk analysisAdultMalemedicine.medical_specialtyInternationalityPopulationStatistics as TopicNorthern Ireland030204 cardiovascular system & hematologyCohort Studies03 medical and health sciences0302 clinical medicineRisk FactorsPhysiology (medical)Internal medicineEpidemiologyMedicineHumans030212 general & internal medicineProspective StudiesRisk factoreducationFinlandAgedBiological Specimen Bankseducation.field_of_studybusiness.industryHazard ratioConfoundingMiddle Aged3. Good healthSurgeryCardiovascular DiseasesPopulation SurveillanceCohortBiomarker (medicine)FemaleCardiology and Cardiovascular MedicinebusinessBiomarkersFollow-Up StudiesCirculation
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The response of Brent crude oil to the European central bank monetary policy

2022

Este artículo examina el impacto de las decisiones de política monetaria del Banco Central Europeo (BCE) sobre los precios del petróleo y la liquidez mediante un estudio de eventos con datos intradía. Analizamos el período de enero de 1999 a diciembre de 2020, que incluye la crisis financiera que comenzó en agosto de 2007. Nuestros resultados muestran una respuesta significativa de los rendimientos del petróleo solo durante la crisis financiera. Específicamente, encontramos que los rendimientos de los futuros de petróleo crudo Brent respondieron negativamente a variaciones inesperadas en la prima de riesgo italiana como medida de acciones de política monetaria no convencionales, y positivam…

Risk premiummedia_common.quotation_subjectMonetary policymonetary policyUNESCO::CIENCIAS ECONÓMICASMonetary economics:CIENCIAS ECONÓMICAS [UNESCO]european central bankInterest rateMarket liquidityBrent Crudesymbols.namesakeExchange rateFinancial crisisEconomicssymbolsbrent crude oil futuresFutures contracthealth care economics and organizationsFinancemedia_common
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Derivative Disclosure Practices in the Annual Financial Reporting of Large European Banks: A Cross-country Empirical Study

2018

The topic of this paper is derivative reporting in banking. The authors employ content analysis to conduct an empirical study on a sample of large European banks. The research aims to assess the qualitative and quantitative profiles of derivative disclosure in banking institutions. The paper provides evidences that banks differ in their derivative reporting, even though they are subject to similar regulatory requirements and accounting standards. The paper also shows that there is room to improve various aspects of derivatives disclosure in banking.

Risk reporting Risk disclosure Derivative Banking Financial regulation Risk management Financial reporting.Settore SECS-P/11 - Economia Degli Intermediari Finanziari
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Expansión y crecimiento de las cooperativas de crédito durante el período 1993-2007 en la Comunidad Valenciana

2009

La Comunidad Valenciana es junto con Andalucía y el País Vasco, las Comunidades Autónomas donde más imbricadas se hallan las cooperativas de crédito; estas se han vinculado al sector agrario vía cajas rurales en las dos primeras, y al sector industrial, vía cajas populares, en la tercera. En este trabajo se analiza la evolución en los últimos quince años, período 1993-2007, del crédito cooperativo en la Comunidad Valenciana, materializado en el estudio de las cajas rurales con sede social en la misma. En él destacamos la experiencia de concentración de algunas entidades, así como la reciente creación de otras a partir de secciones de crédito de cooperativas agrarias. El estudio se efectúa c…

Rural Savings BanksConcentrationMergerCooperative Credit ; Rural Savings Banks ; Concentration ; Strategies ; MergerUNESCO::CIENCIAS ECONÓMICASConcentraciónLa ConcentrationUn crédit Coopératif ; les Boîtes rurales ; La Concentration ; Les Stratégies ; Les FusionsLes Stratégies:CIENCIAS ECONÓMICAS [UNESCO]FusionesCrédito Cooperativo ; Cajas rurales ; Concentración ; Estrategias ; FusionesCrédito CooperativoLes FusionsStrategiesUn crédit Coopératifles Boîtes ruralesCooperative CreditCajas ruralesEstrategias
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