Search results for " based"

Off-Target-Based Design of Selective HIV-1 PROTEASE Inhibitors

2021

The approval of the first HIV-1 protease inhibitors (HIV-1 PRIs) marked a fundamental step in the control of AIDS, and this class of agents still represents the mainstay therapy for this illness. Despite the undisputed benefits, the necessary lifelong treatment led to numerous severe side-effects (metabolic syndrome, hepatotoxicity, diabetes, etc.). The HIV-1 PRIs are capable of interacting with “secondary” targets (off-targets) characterized by different biological activities from that of HIV-1 protease. In this scenario, the in-silico techniques undoubtedly contributed to the design of new small molecules with well-fitting selectivity against the main target, analyzing possible undesirabl…

Relative validity of a short food frequency questionnaire assessing adherence to the Norwegian dietary guidelines among colorectal cancer patients

2018

Background: The Norwegian food-based dietary guidelines (FBDG) aim at reducing the risk of developing chronic diseases and promote overall health. We studied the effect of the Norwegian FBDG in colorectal cancer (CRC) patients. There is a need for a time-efficient dietary assessment tool measuring adherence to these guidelines in patients treated for dietary dependent cancer, such as CRC patients. Objective: To evaluate a new short food frequency questionnaire (NORDIET-FFQ), developed to estimate adherence to the Norwegian FBDG among CRC patients. Design: Eighty-one CRC patients from both study groups in the Norwegian Dietary Guidelines and Colorectal Cancer Survival study, an ongoing dieta…

Athletic abs or big bellies:The impact of imagery, arousal levels, and health consciousness on consumers’ attitudes towards plant-based protein produ…

2021

Abstract Research suggests that health-related imagery influences consumers’ product attitudes, and that both appetitive, positively framed and aversive, negatively framed imagery can be used to boost health-related responses. Arousal has been suggested as a mechanism driving such responses, but few studies in food-related consumer research have examined the link between arousal and consumers’ product attitudes. The present cross-national study, involving almost 1000 consumers (N = 959) from Denmark, Germany, Spain, and the UK, experimentally investigated whether prior exposure to healthy (vs. unhealthy) imagery influences consumers’ attitudes towards a plant-based protein product. Furtherm…

Long-term home-based physiotherapy for persons with signs of frailty–RCT (NCT02305433)

2018

Introduction/Background Frailty is a multidimensional condition, which can lead to disability. To postpone long-term care, one alternative is home-based physiotherapy. We study the effects of a 12-month home-based physiotherapy program on functional capacity, and applying successive 12-month register follow-up, on the use and costs of social and health care services, and on the duration of living at home during 24 months (the primary outcome). Here we report about feasibility of the intervention and baseline characteristics. Material and method Three hundred home-dwelling persons (>65 y) with signs of frailty were recruited by September, 2016. Frailty was screened by Morley's FRAIL question…

Effects of a home-based rehabilitation program in community-dwelling older people after discharge from hospital: A subgroup analysis of a randomized …

2021

Objective: To examine whether pre-admission community mobility explains the effects of a rehabilitation program on physical performance and activity in older adults recently discharged from hospital. Design: A secondary analysis of a randomized controlled trial. Setting: Home and community. Participants: Community-dwelling adults aged ⩾60 years recovering from a lower limb or back injury, surgery or other disorder who were randomized to a rehabilitation ( n = 59) or standard care control ( n = 58) group. They were further classified into subgroups that were not planned a priori: (1) mild, (2) moderate, or (3) severe pre-admission restrictions in community mobility. Interventions: The 6-mont…

Observed teaching practices interpreted from the perspective of school-based teacher educators

2021

A teacher supervising the school practice of student teachers is regarded as an expert who sets an example of good teaching to future teachers and chooses teaching practices that support pupils’ co...

Forms and functions of non-renditions in community interpreting: a corpus-based study

2021

This paper explores flexible language strategies in interpreter-mediated interaction from a corpus-based, quantitative perspective, drawing on data from the Community Interpreting Database (ComInDa...

From engl-isc to whatever-ish: a corpus-based investigation of -ish derivation in the history of English

2020

Drawing on a wide array of historical and contemporary corpora, this article provides one of the first empirical analyses of the intricately related functional changes that -ish underwent in the course of English language history. By investigating the distribution of -ish formations, the analysis sheds light on the productivity of the suffix, which does not only become evident in the numerous hapax legomena, but also in the trajectory of change itself in which -ish occurs with ever new base categories and new functions. Moreover, the article revisits theoretical claims made in the literature about the diachronic development and synchronic properties of -ish and reassesses them in the light …

Teacher-rated aggression and co-occurring behaviors and problems among schoolchildren: A comparison of four population-based European cohorts

2019

AbstractAggressive behavior in school is an ongoing concern, with the current focus mostly on specific manifestations such as bullying and extreme violence. Children spend a substantial amount of time in school, but their behaviors in the school setting tend to be less well characterized than in the home setting. Since aggression may index multiple behavioral problems, we assessed associations of teacher-rated aggressive behavior with co-occurring externalizing/internalizing problems and social behavior in 39,936 schoolchildren from 4 population-based cohorts from Finland, the Netherlands, and the UK. Mean levels of aggressive behavior differed significantly by gender. Correlations of aggre…

2021

Aggressive behavior in school is an ongoing concern. The current focus is on specific manifestations such as bullying, but the behavior is broad and heterogenous. Children spend a substantial amount of time in school, but their behaviors in the school setting tend to be less well characterized than at home. Because aggression may index multiple behavioral problems, we used three validated instruments to assess means, correlations and gender differences of teacher-rated aggressive behavior with co-occurring externalizing/internalizing problems and social behavior in 39,936 schoolchildren aged 7–14 from 4 population-based cohorts from Finland, the Netherlands, and the UK. Correlations of aggr…