Search results for " bene"
showing 10 items of 439 documents
Health benefits of pistachios consumption
2017
The health benefits of nuts, mainly in relation to the improvement of dysmetabolic conditions such as obesity, type 2 diabetes mellitus and the related cardiovascular diseases, have been widely demonstrated. Compared to other nuts, pistachios have a lower fat and caloric content, and contain the highest levels of unsaturated fatty acids, potassium, γ-tocopherol, phytosterols and xanthophyll carotenoids, all substances that are well known for their antioxidant and anti-inflammatory actions. This variety of nutrients contributes to the growing body of evidence that the consumption of pistachios improves health, leading to a greater potential of healthy antioxidant and anti-inflammatory activi…
A Business-Driven Process Model for Knowledge Security Risk Management
2019
This chapter introduces a model to manage knowledge security risks in organizations. Knowledge security risk management is a process that should always be done in connection with the business benefits assessment and realization. The process model presented helps to identify knowledge security risks and provides a comprehensive approach to evaluating and balancing the costs and benefits of knowledge sharing and knowledge risk management and is discussed in light of the benefits realization process. The process model can be a valuable tool for practitioners aiming to develop knowledge sharing practices in companies, and at the same time need to consider the security of knowledge. It is also a…
Inhaled steroids and prevalence of osteoporosis in chronic obstructive pulmonary disease: Data from the DACCORD cohort
2020
Introduction: Osteoporosis is a frequent COPD comorbidity with age, female gender, smoking, immobility and the use of oral steroids (OCS) as common risk factors. The role of inhaled steroids (ICS) is still under debate. Methods: Baseline data from the real life cohort DACCORD were analyzed. The diagnosis of osteoporosis was based on patients’ reports of physician-based diagnoses. Associations of ICS exposure at time of inclusion and osteoporosis were examined by group comparisons and multivariable logistic regression analyses with age, gender, smoking, exacerbation history (EH) and FEV1% as covariates. To avoid interactions with other steroid containing medications, exposure to any corticos…
A phase III study of futibatinib (TAS-120) versus gemcitabine-cisplatin (gem-cis) chemotherapy as first-line (1L) treatment for patients (pts) with a…
2020
TPS600 Background: Pts with adv CCA have poor survival outcomes, and chemotherapy offers limited survival benefit (5-year survival rates, 5–10%; median overall survival [OS], 8–12 months). FGFR2 gene rearrangements are known to be early drivers of oncogenesis in ~15% of pts with intrahepatic (i) CCA. Futibatinib, an oral, highly selective, irreversible FGFR1-4 inhibitor has shown antitumor activity against a broad spectrum of FGFR-deregulated tumors in preclinical studies. In a previous study, futibatinib demonstrated clinical activity and tolerability in heavily pretreated pts with adv CCA harboring FGFR2 gene rearrangements. This phase 3 trial (FOENIX-CCA3) is designed to evaluate futiba…
BIOM-08. DNA METHYLATION-BASED SUBGROUPING PREDICTS SURVIVAL BENEFIT FROM LOMUSTINE/TEMOZOLOMID COMBINATION THERAPY IN MGMT PROMOTOR-METHYLATED GLIOB…
2021
Abstract BACKGROUND The CeTeG/NOA-09 trial showed that lomustine/temozolomide chemotherapy prolongs survival for newly diagnosed MGMT-methylated glioblastoma patients. Previous reports on temozolomide monotherapy suggested, that the survival benefit of temozolomide in MGMT-methylated tumors may be restricted to the RTK II methylation subgroup and absent in RTK I and MES subgroups. To identify patients with a particularly strong benefit from CCNU/TMZ, we explored the association of methylation subgroups with outcome after lomustine/temozolomide therapy. METHODS All patients from the CeTeG/NOA-09 trial with sufficiently available tumor tissue (n = 98) underwent 850K methylation array analysis…
Cancer and Pregnancy: A Comprehensive Review
2021
Simple Summary The co-occurrence of cancer and pregnancy is fortunately a rare event. It is a challenging situation for all involved parties, as the risks and benefits of oncological treatments should be balanced for both the mother and the offspring. This work offers guidance to clinicians regarding the choice of diagnostic and therapeutic procedures, as well as regarding the management of the pregnancy. Abstract Cancer diagnosis and treatment in pregnant women is a challenging situation. A multidisciplinary network of specialists is required to guide both, the expecting mother and the unborn child through the diagnostic workup and the cytotoxic therapy, by balancing the respective risks a…
Capitale sociale e legalità debole
2008
In sociologia, in economia e in scienza politica l’utilizzo del concetto di capitale sociale è ormai frequentissimo, e spesso con significati diversi, parzialmente sovrapposti o discordanti. Dopo una rapidissima rassegna degli autori più influenti, vengono indicati, riallacciandosmi alla teoria dei beni pubblici e dei beni collettivi riconducibile a Samuelson e a Olson, due distinti significati di “capitale sociale”, che designano in effetti fenomeni tra loro diversi, dalla conseguenze talora opposte: capitale sociale come bene pubblico e capitale sociale come bene particolaristico. Nel paragrafo successivo si evidenzia come alcune entità sociali certamente rilevanti dal punto di vista del …
Caritas e bene comune
2014
Tra il XIII e il XIV secolo in Italia, e soprattutto a Firenze, prende forma una nuova ideologia del «bene comune», molto legata al rafforzamento dello «stato» comunale durante la fase caratterizzata dal dominio del «popolo» . Alla base di questo rinnovamento sta l’esplicita politicizzazione della virtù cristiana della carità. Il legame politico rientrava tradizionalmente nelle categorie dell’amicizia e dell’amore, non della carità, virtù «universale» che legava l’uomo a Dio e gli uomini tra di loro nella comunità della chiesa: il sistema tomista fornisce un rappresentazione codificata di questa logica. Viceversa, alcuni autori, da Tolomeo da Lucca a Remigio de’Girolami a Coluccio Salutati,…
Jacopo Salemi: un modello ligneo per il monastero di San Nicolò l'Arena a Catania
2014
Jacopo Salemi, architetto e scultore proveniente dalla città di Castrogiovanni, il giorno 8 novembre 1563 a Catania, sottoscrive un contratto con la congregazione dei monaci benedettini per la costruzione di un modello in legno della chiesa San Nicolò l’Arena che si stava costruendo dal 1558 sul confine ovest della città. Il documento che regola l’incarico tra Salemi e i benedettini è datato 24 febbraio 1564 ed è custodito presso l’Archivio di Stato di Catania; tale documento rivela che il modello realizzato da Salemi sarebbe stato valutato da due esperti incaricati provenienti dalla città di Messina. Le ragioni di una tale commissione potrebbe essere stata connessa alla necessità di verifi…
Challenges and opportunities for citrus wastewater management and valorisation: A review.
2022
Citrus wastewaters (CWWs) are by-products of the citrus fruit transformation process. Currently, more than 700 million of m³ of CWWs per year are produced worldwide. Until nowadays, the management of CWWs is based on a take-make-use-dispose model. Indeed, after being produced within a citrus processing industry, CWWs are subjected to treatment and then discharged into the environment. Now, the European Union is pushing towards a take-make-use-reuse management model, which suggests to provide for the minimization of residual pollutants simultaneously with their exploitation through a biorefinery concept. Indeed, the recovery of energy nutrients and other value-added products held by CWWs may…