Search results for " beta Subunit"

showing 4 items of 24 documents

NG2-expressing cells in the nervous system revealed by the NG2-EYFP-knockin mouse.

2008

The NG2 glycoprotein is a type I membrane protein expressed by immature cells in the developing and adult mouse. NG2+ cells of the embryonic and adult brain have been principally viewed as oligodendrocyte precursor cells but have additionally been considered a fourth glial class. They are likely to be a heterogeneous population. In order to facilitate studies on the function of NG2+ cells and to characterize these cells in situ, we generated an enhanced yellow fluorescent protein (EYFP) “knockin mouse.” EYFP-expressing cells in heterozygous knockin mice expressed the NG2 protein in all regions and at all ages studied. The EYFP+ cells did not express markers of mature glia, developing or mat…

Nervous systemYellow fluorescent proteinTransgenePopulationHippocampusS100 Calcium Binding Protein beta SubunitHippocampusNervous SystemMiceEndocrinologyBacterial ProteinsGlutamate-Ammonia LigaseGeneticsmedicineAnimalsGene Knock-In TechniquesNerve Growth FactorsAntigenseducationPromoter Regions GeneticCells CulturedNeuronseducation.field_of_studyMicrogliabiologyS100 ProteinsBrainGene Expression Regulation DevelopmentalCell BiologyEmbryonic stem cellCell biologyLuminescent ProteinsOligodendrogliamedicine.anatomical_structurenervous systemMembrane proteinAstrocytesImmunologybiology.proteinProteoglycansMicrogliaGenesis (New York, N.Y. : 2000)
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Polymorphisms in DCDC2 and S100B associate with developmental dyslexia

2015

Genetic studies of complex traits have become increasingly successful as progress is made in next-generation sequencing. We aimed at discovering single nucleotide variation present in known and new candidate genes for developmental dyslexia: CYP19A1, DCDC2, DIP2A, DYX1C1, GCFC2 (also known as C2orf3), KIAA0319, MRPL19, PCNT, PRMT2, ROBO1 and S100B. We used next-generation sequencing to identify single-nucleotide polymorphisms in the exons of these 11 genes in pools of 100 DNA samples of Finnish individuals with developmental dyslexia. Subsequent individual genotyping of those 100 individuals, and additional cases and controls from the Finnish and German populations, validated 92 out of 111 …

Nonsynonymous substitutionCandidate genemedicine.medical_specialtyShort CommunicationGenomicsS100 Calcium Binding Protein beta SubunitBiologyPolymorphism Single NucleotideDyslexia03 medical and health sciences0302 clinical medicineDCDC2Molecular geneticssingle-nucleotide polymorphismsmedicineHumansGenetic Predisposition to DiseasegeneticsGenotypingGenetic Association StudiesGenetics (clinical)ta515030304 developmental biologyGenetics0303 health sciencesperinnöllisyystiedeta1184DyslexiaSequence Analysis DNAmedicine.diseasedevelopmental dyslexiata3124Genetic epidemiologyCase-Control Studiesindividual genotypingMicrotubule-Associated Proteins030217 neurology & neurosurgeryJournal of Human Genetics
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The Yin and Yang of alarmin S100B in the protection of myocardium

2021

business.industryMyocardiumMyocardial InfarctionAlarminsHumansMedicineS100 Calcium Binding Protein beta SubunitGeneral MedicineCardiology and Cardiovascular MedicinebusinessNeuroscienceYin and yangArchives of Cardiovascular Diseases
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Additive effect of factors related to assisted conception on the reduction of maternal serum pregnancy-associated plasma protein A concentrations and…

2013

Objective To analyze whether assisted conceptions need adjustments in first-trimester Down syndrome screening and why modifications in screening markers occur. Design Eleven-year cohort retrospective analysis. Setting Maternal-fetal medicine unit. Patient(s) Two thousand eleven naturally conceived normal singleton pregnancies and 2,042 normal singleton pregnancies achieved with assisted conception: 350 by IUI and 1,692 with IVF (n = 328) or intracytoplasmic sperm injection (ICSI; n=1,364), using nondonor (n = 1,086) or donated ova (n = 606), with fresh (n = 1,432) or frozen (n = 260) embryos. Intervention(s) Comparison of ultrasound and biochemical markers of first-trimester Down syndrome s…

medicine.medical_specialtyPregnancy-associated plasma protein AReproductive Techniques Assistedmedicine.medical_treatmentDown-RegulationFertilization in VitroIntracytoplasmic sperm injectionEmbryo cryopreservationPredictive Value of TestsPregnancyPrenatal DiagnosismedicineHumansPregnancy-Associated Plasma Protein-AChorionic Gonadotropin beta Subunit HumanFalse Positive Reactionsreproductive and urinary physiologyInsemination ArtificialRetrospective StudiesGynecologyDown syndrome screeningAnalysis of VarianceChi-Square DistributionOocyte Donationbusiness.industrySingletonFree βhcgObstetrics and GynecologyPregnancy Trimester FirstReproductive MedicineCohortFemaleHormone therapyDown SyndromebusinessNuchal Translucency MeasurementBiomarkersFertility and sterility
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