Search results for " bioengineering"

showing 10 items of 119 documents

Targeted tumor imaging of anti-CD20-polymeric nanoparticles developed for the diagnosis of B-cell malignancies

2015

Sara Capolla,1 Chiara Garrovo,2 Sonia Zorzet,1 Andrea Lorenzon,3 Enrico Rampazzo,4 Ruben Spretz,5 Gabriele Pozzato,6 Luis Núñez,7 Claudio Tripodo,8 Paolo Macor,1,9 Stefania Biffi2 1Department of Life Sciences, University of Trieste, 2Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”, Trieste, 3Animal Care Unit, Cluster in Biomedicine (CBM scrl), Trieste, Italy; 4Department of Chemistry “G. Ciamician”, University of Bologna, Bologna, Italy; 5LNK Chemsolutions LLC, Lincoln, NE, USA; 6Department of Medical, Surgery and Health Sciences, University of Trieste, Trieste, Italy; 7Bio-Target, Inc., University of C…

Medicine (General)Active targeting; Optical imaging; Tumor accumulation; Animals; Antigens CD20; Cell Line Tumor; Humans; Leukemia B-Cell; Mice; Molecular Imaging; Nanoparticles; Polymers; Drug Delivery Systems; Bioengineering; Biophysics; Biomaterials; Drug Discovery3003 Pharmaceutical Science; Organic ChemistryTumor accumulationPolymersPharmaceutical SciencePharmacologyOptical imagingMiceDrug Delivery SystemsNanoparticleInternational Journal of NanomedicineDrug DiscoveryPolymerOriginal ResearchActive targeting; Optical imaging; Tumor accumulation; Animals; Antigens CD20; Cell Line Tumor; Humans; Leukemia B-Cell; Mice; Molecular Imaging; Nanoparticles; Polymers; Drug Delivery Systems; Biophysics; Bioengineering; Biomaterials; Organic Chemistry; Drug Discovery3003 Pharmaceutical ScienceTumorLeukemiaActive targetingtumor accumulationGeneral MedicineMolecular ImagingDrug deliverySystemic administrationPreclinical imagingHumanactive targetingMaterials scienceBiophysicsBioengineeringCell LineBiomaterialsoptical imagingR5-920In vivoCell Line TumormedicineLeukemia B-CellDistribution (pharmacology)AnimalsHumansCD20AntigensAnimalDrug Discovery3003 Pharmaceutical ScienceOrganic ChemistryB-CellCancermedicine.diseaseAntigens CD20BiomaterialTargeted drug deliveryBiophysicNanoparticlesMolecular imagingDrug Delivery System
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Sequential batch membrane bio-reactor for wastewater treatment: The effect of increased salinity

2016

In this work, a sequential batch membrane bioreactor pilot plant is investigated to analyze the effect of a gradual increase in salinity on carbon and nutrient removal, membrane fouling and biomass kinetic parameters. The salinity was increased by 2 g NaCl L-1 per week up to 10 g NaCl L-1. The total COD removal efficiency was quite high (93%) throughout the experiment. A gradual biomass acclimation to the salinity level was observed during the experiment, highlighting the good recovery capabilities of the system. Nitrification was also influenced by the increase in salinity, with a slight decrease in nitrification efficiency (the lowest value was obtained at 10 g NaCl L-1 due to lower nitri…

Membrane foulingSalinityRespirometric batch testEnvironmental EngineeringBiofoulingOrganic carbon and nitrogen removal0208 environmental biotechnologyBiomassPilot ProjectsBioengineering02 engineering and technologyWastewater010501 environmental sciencesMembrane bioreactor01 natural sciencesBioreactorsWaste ManagementExtracellular polymeric substanceBioreactorBiomassWaste Management and Disposal0105 earth and related environmental sciencesBiological Oxygen Demand AnalysisFoulingSettore ICAR/03 - Ingegneria Sanitaria-AmbientaleRenewable Energy Sustainability and the EnvironmentChemistryMembrane foulingEnvironmental engineeringMembranes ArtificialGeneral MedicinePulp and paper industryNitrificationCarbon020801 environmental engineeringSalinityWastewaterExtracellular polymeric substances; Membrane fouling; Organic carbon and nitrogen removal; Respirometric batch tests; Salinity; Bioengineering; Environmental Engineering; Waste Management and DisposalNitrification
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Biocompatibility of Mineral Trioxide Aggregate with TiO2 Nanoparticles on Human Gingival Fibroblasts

2016

Background The New compositions of white mineral trioxide aggregate (WMTA) or use of various additives like nanoparticles might affect MTA’s ideal characteristics This study was performed to evaluate the cytotoxicity of WMTA and WMTA with Titanium dioxide (TiO2) nanoparticles (1% weight ratio) at different storage times after mixing on human gingival fibroblasts (HGFs). Material and Methods HGFs were obtained from the attached gingiva of human premolars. HGFs were cultured in Dulbecco’s Modified Eagle medium, supplemented with 10% fetal calf serum, penicillin and streptomycin. The cells were exposed to WMTA (groups 1 and 2) and WMTA+TiO2 (groups 3 and 4). The fifth and sixth groups served a…

Mineral trioxide aggregateBiocompatibilityDentistryOdontología02 engineering and technologyAndrology03 medical and health sciences0302 clinical medicineBiomaterials and Bioengineering in DentistrymedicineStatistical analysisMTT assayCytotoxicityFibroblastGeneral Dentistrybusiness.industryChemistryResearchTio2 nanoparticles030206 dentistry021001 nanoscience & nanotechnology:CIENCIAS MÉDICAS [UNESCO]Ciencias de la saludmedicine.anatomical_structureToxicityUNESCO::CIENCIAS MÉDICAS0210 nano-technologybusiness
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Effect of pH on compressive strength of some modification of mineral trioxide aggregate

2013

Objectives: Recently, it was shown that NanoMTA improved the setting time and promoted a better hydration process which prevents washout and the dislodgment of this novel biomaterial in comparison with WTMA. This study analyzed the compressive strength of ProRoot WMTA (Dentsply), a NanoWMTA (Kamal Asgar Research Center), and Bioaggregate (Innovative Bioceramix) after its exposure to a range of environmental pH conditions during hydration. Study Design: After mixing the cements under aseptic condition and based on the manufacturers' recommendations, the cements were condensed with moderate force using plugger into 9 × 6 mm split molds. Each type of cement was then randomly divided into three…

Mineral trioxide aggregateMaterials sciencePost hocCompressive StrengthDental CementsOdontologíaCalcium Hydroxidechemistry.chemical_compoundDental cementBiomaterials and Bioengineering in DentistryMaterials TestingPolymethyl MethacrylateComposite materialAluminum CompoundsGeneral DentistryCementCalcium hydroxideSilicatesWashoutBiomaterialOxidesCalcium CompoundsHydrogen-Ion Concentration:CIENCIAS MÉDICAS [UNESCO]Ciencias de la saludDrug CombinationsCompressive strengthOtorhinolaryngologychemistryUNESCO::CIENCIAS MÉDICASSurgeryResearch-ArticleHydroxyapatitesMedicina Oral, Patología Oral y Cirugía Bucal
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Effect of different mixing and placement methods on the quality of MTA apical plug in simulated apexification model

2017

Background It is necessary apical plug material to exhibit proper adaptation with the root canal walls. Presence of voids at the interface between the root canal wall and this material result in micro leakage, which might have a relationship with post treatment disease. The aim of the present study was to evaluate the effect of different mixing (manual and ultrasonic) and placement (manual and manual in association with indirect ultrasonic) method of Mineral Trioxide Aggregate (MTA) on the void count and dimension in the apical plug in natural teeth with simulated open apices. Material and methods Eighty human maxillary central incisors were selected. After simulation of the open apex model…

Mineral trioxide aggregateVoid (astronomy)Cone beam computed tomographyMaterials scienceRoot canal0206 medical engineeringDentistry02 engineering and technologyApical plug03 medical and health sciences0302 clinical medicineBiomaterials and Bioengineering in DentistrymedicineMaxillary central incisorGeneral DentistryOrthodonticsbusiness.industryResearch030206 dentistry:CIENCIAS MÉDICAS [UNESCO]020601 biomedical engineeringmedicine.anatomical_structureUNESCO::CIENCIAS MÉDICASApexificationUltrasonic sensorbusiness
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A preliminary clinical trial using flowable glass-ionomer cement as a liner in proximal-ART restorations: the operator effect

2013

Objectives: This in vivo study was carried out to assess the influence of the operator experience on the survival rate of proximal-ART restorations using a two-layer technique to insert the glass-ionomer cement (GIC). Study Design: Forty five proximal cavities in primary molars were restored in a school setting according to the ART technique. The cavities were restored by two operators with Ketac Molar Easymix, and received a flowable layer of GIC prior to a second GIC layer with a regular consistency. The operators had different clinical experiences with ART (no experience or two years of experience), but both completed a one-week training to perform the restorations and the GIC mixing in …

MolarGlass ionomer cementDentistryOdontologíaDental CariesBiomaterials and Bioengineering in DentistryHumansMedicineChildGeneral DentistryDental Atraumatic Restorative TreatmentKetac Molar Easymixbusiness.industryDental Atraumatic Restorative TreatmentSchool setting:CIENCIAS MÉDICAS [UNESCO]Ciencias de la saludClinical trialRestorative treatmentOtorhinolaryngologyGlass Ionomer CementsChild PreschoolUNESCO::CIENCIAS MÉDICASResearch-ArticleSurgerybusiness
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Effect of a plant-based hemostatic agent on microleakage of self-etching adhesives

2012

Objective: This in vitro study evaluated the effect of Ankaferd Blood Stopper (ABS) contamination on the micro-leakage of one-step and two-step self-etching adhesives.

MolarMaterials scienceDentistryDental CementsOdontologíaIn Vitro Techniquesstomatognathic systemDental cementBiomaterials and Bioengineering in DentistryDentinmedicineHumansDental EtchingGeneral DentistrySelf etching adhesiveDental Leakagebusiness.industryPlant ExtractsBuccal administrationContamination:CIENCIAS MÉDICAS [UNESCO]Ciencias de la saludmedicine.anatomical_structureOtorhinolaryngologyDental EtchingUNESCO::CIENCIAS MÉDICASSurgeryResearch-ArticleAdhesivebusiness
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Evaluation of marginal sealing quality of restorations with low shrinkage composite resins

2020

Background This study compared the quality of marginal sealing in the gingival wall of class II preparations of two low-shirinkage resins of the bulk fill type with a conventional resin isolated or associated with a glass ionomer cement (GIC). Material and methods 40 human molars were divided into 4 groups and 80 occlusal-mesial and occlusal-distal restorations were performed with the following materials: SureFil SDR flow, Filtek Bulk Fill Posterior, Z250 resins and Riva Light Cure GIC. 40 restorations were evaluated in Scanning Electron Microscopy (SEM) with Elemental Microanalysis Spectrometry (EDS) initially and the remainder after a period of 6 months of aging in a 37 ± 5°C oven. An ave…

MolarMaterials scienceScanning electron microscopeResearchResin composite0206 medical engineeringComposite numberGlass ionomer cementFiltek Bulk FillBulk fill030206 dentistry02 engineering and technology020601 biomedical engineering03 medical and health sciences0302 clinical medicinestomatognathic systemBiomaterials and Bioengineering in DentistryLow shrinkageComposite materialGeneral DentistryUNESCO:CIENCIAS MÉDICASJournal of Clinical and Experimental Dentistry
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Effect of adhesive layers on microshear bond strength of nanocomposite resin to dentin

2016

BACKGROUND Bond strength of adhesive layer can absorb unwanted stresses of polymerization shrinkage in composite resin restorations; increased microshear bond strength can prevent failure of restoration materials, the purpose of this study was to evaluate the effect of adhesive layers on microshear bond strength of nanocomposite resin to dentin. MATERIAL AND METHODS Two different types of adhesive systems: universal adhesive (ExciTE) and newly developed adhesive (Nano-Bond), and one type of light-cured resin restorative material (Nanocomposite resin) were used in this study. The occlusal surfaces of extracted human molar teeth were ground perpendicular to the long axis of each tooth to expo…

MolarNanocompositeMaterials scienceBond strengthResearchComposite numberOdontología:CIENCIAS MÉDICAS [UNESCO]Ciencias de la saludmedicine.anatomical_structurePolymerizationstomatognathic systemBiomaterials and Bioengineering in DentistryUNESCO::CIENCIAS MÉDICASDentinmedicineAdhesiveComposite materialGeneral DentistryShrinkage
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Wetting ability of an acetone/based etch rinse adhesive after NaOCl-treatment

2011

Objectives: to evaluate the effect of sodium hypochlorite (NaOCl) treatment on surface dentin roughness (Ra) and contact angle (CA) when using Prime&Bond NT adhesive (PB NT). Study Design: Extracted human third molars were sectioned to expose flat, superficial and deep dentin surfaces. CA and Ra were measured (1) before and (2) after 35% H3PO4 etching, and (3) H3PO4 etching + 5% NaOCl treated for 2 minutes before the application of PB NT. CA was measured by the Axisymmetric Drop Shape Analysis Technique using distilled and deionized water and PB NT. Roughness was evaluated with a profilometer, twelve radial measurements were performed in each treatment surface. Data were analyzed with two-w…

MolarSodium HypochloriteSurface PropertiesDentistryIn Vitro TechniquesAcetoneContact anglechemistry.chemical_compoundPolymethacrylic Acidsstomatognathic systemMaterials TestingBiomaterials and Bioengineering in DentistryDentinmedicineSurface roughnessHumansGeneral DentistryChemistrybusiness.industry:CIENCIAS MÉDICAS [UNESCO]Demineralizationstomatognathic diseasesmedicine.anatomical_structureOtorhinolaryngologySodium hypochloriteDentinUNESCO::CIENCIAS MÉDICASWettabilityMolar ThirdResearch-ArticleSurgeryWettingAdhesivebusinessNuclear chemistry
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