Search results for " board"
showing 10 items of 178 documents
Effective childhood cancer treatment: The impact of large scale clinical trials in Germany and Austria
2013
In Germany and Austria, more than 90% of pediatric cancer patients are enrolled into nationwide disease-specific first-line clinical trials or interim registries. Essential components are a pediatric cancer registry and centralized reference laboratories, imaging review, and tumor board assistance. The five-year overall survival rate in countries where such infrastructures are established has improved from 80% since 1995. Today, treatment intensity is tailored to the individual patient's risk to provide the highest chances of survival while minimizing deleterious late effects. Multicenter clinical trials are internationalized and serve as platforms for further improvements by novel drugs an…
Primary malignant PEComa of the mandible. Report of an unusual case
2021
Malignant PEComa is a rare entity that usually origins at visceral, retroperitoneal and abdominopelvic sites. In the present paper, we describe an extremely unusual manifestation of malignant PEComa involving the mandible in a 48 years-old female patient focusing on the anatomopathological findings and differential diagnosis. The therapeutic management based on the head and neck tumor board indications is also discussed. Key words:Malignant PEComa, PEComa of the mandible, PEComa pathology, Oral cavity unusual neoplasm.
Biomarker testing of lung cancer in Spain
2019
Abstract Background Target therapy guide by biomarkers have become the standard of care for patients with lung cancer (LC). So, identify those molecular alterations is one of the most important care needs nowdays. Our objective was to know the implementation degree of these tests in a large cohort of patients in Spain using the Thoracic Tumor Registry (TTR) of the Grupo Espanol de Cancer de Pulmon (Spanish Lung Cancer Group). Methods The TTR is an observational cohort multicenter study of LC in Spain. The study is conducted according to the Declaration of Helsinki and approved by the institutional review board of each participating institute. The registry was approved by the Spanish Drug Ag…
Tobacco use in lung cancer (LC) patients (p) in Spain
2019
Abstract Background Tobacco use, mainly as cigarette smoking, is the leading cause of lung cancer. Eighty-five percent of LC occur in smokers. Understanding the Spanish smoking habits allows the government to design health care policies against this consumption. To do so, the Grupo Espanol de Cancer de Pulmon (Spanish Lung Cancer Group) made this analysis within the context of the Thoracic Tumor Registry (TTR). Methods The TTR is an observational cohort multicenter study in Spain. The study is conducted according to the Declaration of Helsinki and approved by the institutional review board of each participating site. The registry was approved by the Spanish Drug Agency, as a non-post-author…
Tumor Board and Molecular Tumor Board
2021
Specialized expertise and cooperation between different professional figures are increasingly needed for the management of cancer patients. Tumor boards (TB) can address this issue by gathering together different healthcare providers to periodically discuss challenging cases.
The GALAD Score as Potential Screening Test for Hepatocellular Carcinoma in Nonalcoholic Steatohepatitis: An International Multicenter Study
2019
The prevalence of nonalcoholic steatohepatitis (NASH) is rising rapidly and is currently the most common chronic liver disease in Western populations. Hepatocellular carcinoma (HCC) is a major complication of NASH and the current performance of screening approaches based on ultrasound shows limitations. To facilitate earlier diagnosis, this international multicenter study, with eight German and one Japanese center participating, tests the potential benefit of applying the biomarkers AFP, AFP-L3, DCP and related scores for HCC screening in NASH patients. In the retrospective German cohort, 126 NASH patients with newly diagnosed HCC and 231 NASH control patients without HCC were enrolled. In …
Whole-body MRI, FDG-PET/CT, and bone marrow biopsy, for the assessment of bone marrow involvement in patients with newly diagnosed lymphoma
2016
Purpose To compare whole-body MRI (WB-MRI) with diffusion-weighted imaging (DWI), FDG-PET/CT, and bone marrow biopsy (BMB), for the evaluation of bone marrow involvement (BMI) in patients with newly diagnosed lymphoma. Materials and Methods This retrospective study was approved by our Institutional Review Board. Two independent radiologists and one nuclear medicine specialist reviewed all WB-MRI and FDG-PET/CT scans prospectively performed on 104 patients with newly diagnosed lymphoma (53 males; 47 Hodgkin; mean age: 44 years; range, 15–86 years) between 2013 and 2015. The delay between imaging scans and BMBs was up to 10 days. The diagnostic accuracy of WB-MRI (1.5 Tesla MR scanner, with T…
Le commissioni di ricorso nel sistema di giustizia dell'Unione europea
2020
Le commissioni di ricorso nel diritto dell’Unione europea sono organi amministrativi, incaricati di risolvere controversie nei settori di competenza degli Uffici, Agenzie ed Autorità presso cui sono strutturate. Esercitano una sicura attività giustiziale, rafforzata dal carattere del loro intervento, che è pregiudiziale rispetto all’ordinaria tutela giurisdizionale. L’interesse per il tema è determinato anche dall’orientamento della giurisprudenza, esaminato nel volume. È invero prevalsa l’interpretazione della c.d. “continuità funzionale”, secondo cui le commissioni di ricorso svolgerebbero la stessa attività degli organi di prima istanza, accentuando gli aspetti amministrativi, a discapit…
Le Currency board : les contraintes de financement et d'ajustement de la convertibilité intégrale
2000
The paper scrutinizes the consequences of the adoption of a currency board arrangement (CBA) by some emerging economies during the 1990s. Considering the justifications o f this choice and the different setting-up contexts, it focuses on the implications of a CBA on the financial system and the real economy. A high degree of liquidity of the banking system is required in the absence of a lender-of-last-resort, and the automatic money supply process strictly disciplines the fiscal policy. Monetary stability is restored; but in most o f these economies where capital markets are underdeveloped, CBA's rules make the domestic credit supply dependent on the ability o f the economy to maintain ove…