Search results for " bodies"
showing 10 items of 250 documents
Embracing water, healing pine : touch-walking and transcorporeal worldings
2023
This article considers touch as an embodied worlding practice in the context of humans intentionally seeking tactile trans-species contact. In particular, it examines three co-researchers’ tactile relations with tree(s) and water which were explored by “touch-walking,” an immersive method developed for this study. The method opened possibilities for examining transcorporeal sensory matterings and affective flows between the researcher’s body, co-researchers’ bodies and more-than-human bodies. This experimental micro-research brings knowledge about how people form deeply meaningful relationships with natural bodies, making worlds by cherishing tactile contact with them. Theoretically, we “po…
Permeability changes of integrin-containing multivesicular structures triggered by picornavirus entry.
2014
Cellular uptake of clustered α2β1-integrin induces the formation of membrane compartments that subsequently mature into a multivesicular body (MVB). Enhanced internalization mediated by clustered integrins was observed upon infection by the picornavirus echovirus 1 (EVI). We elucidated the structural features of virus-induced MVBs (vMVBs) in comparison to antibody-induced control MVBs (mock infection) by means of high-pressure cryo fixation of cells followed by immuno electron tomography during early entry of the virus. Three-dimensional tomograms revealed a marked increase in the size and complexity of these vMVBs and the intraluminal vesicles (ILVs) at 2 and 3.5 hours post infection (p.i.…
[The ketogenic diet: an underappreciated therapeutic option?].
2011
Obesity is reaching epidemic proportions in Western countries and is a strong risk factor for cardiovascular disease. Despite the constant recommendations of health care organizations regarding the importance of weight control, this goal often fails. Although there is a common agreement about the concept that exercise and diet are two key factors for the control of body weight, the ideal amount and type of exercise and also the ideal diet for weight control are still under debate. A widely accepted nutritional regime is the Mediterranean diet that has evident health benefits although less attention has been paid to see if the effects are due to other lifestyle factors which may contribute t…
The White Woman’s Haunted Body in Doris Lessing’s The Grass Is Singing
2012
Underpinned by an interpretative grid where the analytic categories of gender and race are interwoven, the paper contends that Doris Lessing’s first novel, The Grass Is Singing (1950), unveils and dismantles culturally-constructed inscriptions of the white female body as elaborated within the nineteenth- and early twentieth-century British colonial discourses and largely reproduced at folk level. Exploring Lessing’s robust delineation of the entanglements of gendered sexuality and race-biased social constraints as active in the colonial context, the paper also suggests that the novel problematizes and recasts traditional British identity configurations from an authorial perspective which po…
Hypolipidaemic effects of fenofibrate are not altered by mildronate-mediated normalization of carnitine concentration in rat liver.
1999
The five-fold higher carnitine content in the liver of fenofibrate-treated rats addresses the question about the possible role of this enhancement in the hypolipidaemic effect of the drug and the underlying mechanisms. When fenofibrate was administered with mildronate (a gamma-butyrobetaine hydroxylase inhibitor) in suitable amount, the content in carnitine was found to be normalized in liver. However, triglyceride contents of liver and serum were then at least as low as in rats treated by fenofibrate only. When carnitine concentration was lowered by mildronate to the third of the normal value, a marked increase in triglycerides occurred both in liver and serum, while the five-fold increase…
Mildronate: An Antiischemic Drug for Neurological Indications
2005
Mildronate (3-(2,2,2-trimethylhydrazinium)propionate; MET-88; meldonium, quaterine) is an antiischemic drug developed at the Latvian Institute of Organic Synthesis. Mildronate was designed to inhibit carnitine biosynthesis in order to prevent accumulation of cytotoxic intermediate products of fatty acid beta-oxidation in ischemic tissues and to block this highly oxygen-consuming process. Mildronate is efficient in the treatment of heart ischemia and its consequences. Extensive evaluation of pharmacological activities of mildronate revealed its beneficial effect on cerebral circulation disorders and central nervous system (CNS) functions. The drug is used in neurological clinics for the trea…
Coxsackievirus A9 Infects Cells via Nonacidic Multivesicular Bodies
2014
ABSTRACT Coxsackievirus A9 (CVA9) is a member of the human enterovirus B species in the Enterovirus genus of the family Picornaviridae . According to earlier studies, CVA9 binds to αVβ3 and αVβ6 integrins on the cell surface and utilizes β2-microglobulin, dynamin, and Arf6 for internalization. However, the structures utilized by the virus for internalization and uncoating are less well understood. We show here, based on electron microscopy, that CVA9 is found in multivesicular structures 2 h postinfection (p.i.). A neutral red labeling assay revealed that uncoating occurs mainly around 2 h p.i., while double-stranded RNA is found in the cytoplasm after 3 h p.i. The biogenesis of multivesicu…
The p21-activated kinase Mbt is a component of the apical protein complex in central brain neuroblasts and controls cell proliferation
2013
The final size of the central nervous system is determined by precisely controlled generation, proliferation and death of neural stem cells. We show here that the Drosophila PAK protein Mushroom bodies tiny (Mbt) is expressed in central brain progenitor cells (neuroblasts) and becomes enriched to the apical cortex of neuroblasts in a cell cycle- and Cdc42-dependent manner. Using mushroom body neuroblasts as a model system, we demonstrate that in the absence of Mbt function, neuroblasts and their progeny are correctly specified and are able to generate different neuron subclasses as in the wild type, but are impaired in their proliferation activity throughout development. In general, loss of…
γ2-Adaptin is functioning in the late endosomal sorting pathway and interacts with ESCRT-I and -III subunits.
2010
Abstractγ2-Adaptin is a clathrin adaptor-related protein with unclear physiological function. Previous studies indicated that γ2-adaptin might act within the multivesicular body (MVB) protein-sorting pathway that is central to receptor down-regulation, lysosome biogenesis, and budding of enveloped viruses. Here, we have analyzed the effects of excess and deficit γ2-adaptin on exogenous and endogenous MVB cargoes and on the MVB machinery itself. Foreign cargoes, like retroviral Gags, are entrapped by overexpressed γ2-adaptin in detergent-insoluble polymers and blocked in budding. When viral budding involves MVB/endosomal structures, excess γ2-adaptin acts by accelerating lysosomal Gag destru…
Modeling and Parameter Identification of Deflections in Planetary Stage of Wind Turbine Gearbox
2012
The main focus of this paper is the experimental and numerical investigation of a 750[kW] wind turbine gearbox. A detailed model of the gearbox with main shaft has been created using MSC.Adams. Special focus has been put on modeling the planet carrier (PLC) in the gearbox. For this purpose experimental data from a drive train test set up has been analyzed using parameter identification to quantify misalignments. Based on the measurements a combination of main shaft misalignment and planet carrier deflection has been identified. A purely numerical model has been developed and it shows good accordance with the experimental data.