Search results for " box"
showing 10 items of 161 documents
Association between genetic variations in the insulin/insulin-like growth factor (Igf-1) signaling pathway and longevity: a systematic review and met…
2013
Some studies have shown that polymorphisms in the insulin growth factor-1 (IGF-1) signaling pathway genes could influence human longevity. However, the results of different studies are often inconsistent. Our aim was to investigate by systematic review and meta-analysis the association of the common polymorphisms defining the genetic variability of the IGF-1 signaling pathway associated with human longevity. Eleven studies investigating the association between the polymorphisms in the IGF-1 signaling pathway genes (IGF-1, IGF-1 receptor (IGF-1R), Forkhead box O3A (FOXO3A) and Silent mating type Information Regulation 1 (SIRT1) and longevity were found and analyzed. The modelfree approach wa…
2016
Mirror training therapy is a promising tool to initiate neural plasticity and facilitate the recovery process of motor skills after diseases such as stroke or hemiparesis by improving the intermanual transfer of fine motor skills in healthy people as well as in patients. This study evaluated whether these augmented performance improvements by mirror visual feedback (MVF) could be used for learning a sport-specific skill and if the effects are modulated by skill level. A sample of 39 young, healthy, and experienced basketball and handball players and 41 novices performed a stationary basketball dribble task at a mirror box in a standing position and received either MVF or direct feedback. Af…
Virtual reality based robotic therapy for stroke rehabilitation: An initial study
2011
The stroke rate will increase as the population ages. Lots of methods on stroke rehabilitation have been developed in the world. The therapy method based on the mirror box illusion helps the limb practice after stroke. Mirror therapy could be combined to virtual reality (VR) rehabilitation to enhance its effect, using robot to realize the position and force manipulation. Robotic device provide one way to regulate the amount and intensity of movement of the plegic limb and to focus more time on more task-specific and complex functional movements. The purpose of this study is to propose a robot assistant for stroke rehabilitation by utilizing virtual reality technology and sensory feedback, t…
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus
2013
The author manuscript of this article is open access and is freely available online at PubMed Central
Mutations in the NKX2.5 Gene and the PAX8 Promoter in a Girl with Thyroid Dysgenesis
2011
Screening of the known candidate genes involved in thyroid organogenesis has revealed mutations in a small subset of patients with congenital hypothyroidism due to thyroid dysgenesis (TD).We studied a girl with TD who had mutations in two transcription factors involved in thyroid development.Sequencing analysis of candidate genes involved in thyroid gland development revealed a new paternally inherited heterozygous mutation in the NKX2.5 gene (S265R) and a new maternally inherited heterozygous mutation in the PAX8 promoter region (-456CT). Both parents and a brother, who was also heterozygous for both mutations, were phenotypically normal. Immunofluorescence microscopy showed a correct nucl…
Building bridges: future directions for medical error disclosure research.
2013
Abstract Objective The disclosure of medical errors has attracted considerable research interest in recent years. However, the research to date has lacked interdisciplinary dialog, making translation of findings into medical practice challenging. This article lays out the disciplinary perspectives of the fields of medicine, ethics, law and communication on medical error disclosure and identifies gaps and tensions that occur at these interdisciplinary boundaries. Methods This article summarizes the discussion of an interdisciplinary error disclosure panel at the 2012 EACH Conference in St. Andrews, Scotland, in light of the current literature across four academic disciplines. Results Current…
Innovation Box w praktyce – ulga dla programistów
2021
Innovation Box (IP Box) – podatek od dochodu z kwalifikowanych praw własności intelektualnej – pozwala na skorzystanie z preferencyjnej stawki w wysokości 5%, pod warunkiem osiągnięcia przez podatnika dochodu z kwalifikowanych praw własności intelektualnej, a także prowadzenia przez niego działalności badawczo-rozwojowej (w zakresie, w jakim chce skorzystać z powyższego rozwiązania). Ulga ta jest stosowana przede wszystkim przez przedsiębiorców działających w branży IT. Wiążą się z nią obowiązki, w tym obowiązek prowadzenia ewidencji zdarzeń gospodarczych zawierającej operacje finansowe dotyczące dochodów z kwalifikowanych praw własności intelektualnej
Trecento gotico doloroso e cortese in Sicilia: le opere in mostra
2020
Il saggio descrive molte delle opere d'arte del XIV e XV secolo esposte in mostra (dipinti su tavola, sculture lignee, oggetti in argento con smalti, cofanetti in avorio e legno), di fattura locale, italiana, cipriota-egea, iberica, francese e tedesca, tutte provenienti dalla Sicilia, alcune legate alla famiglia Chiaromonte. The essay describes many of the 14th and 15th century works of art on display (paintings on wood, wooden sculptures, silver objects with enamels, ivory and wooden boxes), of local, Italian, Cypriot-egean, Iberian, French and German manufacture, all from Sicily, some related to the Chiaromonte family.
An Ethical Perspective on Loot Box Purchasing : Examining Psychosocial Antecedents and the Association with Indebtedness
2023
Loot boxes are popular random reward mechanisms in digital games, attracting players to invest real money to enhance their gaming experiences. Loot boxes share striking similarities to gambling and might contribute to one’s economic strain, but more research is needed on the underlying vulnerabilities and motivational traits in loot box purchasing. This paper examines associations with self-reported increase in loot box purchasing and debt problems during the first year of the COVID-19 pandemic. International survey data were collected in 2021, consisting of Finnish, Swedish, and British respondents (N = 2,991) aged 18 to 75. Partial least squares modeling was used as an analytical techniqu…
A black-box, general purpose quadratic self-consistent field code with and without Cholesky Decomposition of the two-electron integrals
2021
We present the implementation of a quadratically convergent self-consistent field (QCSCF) algorithm based on an adaptive trust-radius optimisation scheme for restricted open-shell Hartree���Fock (ROHF), restricted Hartree���Fock (RHF), and unrestricted Hartree���Fock (UHF) references. The algorithm can exploit Cholesky decomposition (CD) of the two-electron integrals to allow calculations on larger systems. The most important feature of the QCSCF code lies in its black-box nature ��� probably the most important quality desired by a generic user. As shown for pilot applications, it does not require one to tune the self-consistent field (SCF) parameters (damping, Pulay's DIIS, and other simil…