Search results for " breast"
showing 10 items of 610 documents
Cytotoxic effects induced by JA47, a novel histone deacetylase inhibitor (HDACi), on MDA-MB231 breast cancer cells
2012
JA47, a new histone deacetylase inhibitor that induces cytotoxic effects on triple-negative MDA-MB231 breast cancer cells in vitro
2012
Biological effect of an hybrid anticancer agent based on kinase and histone deacetylase inhibitor on breast cancer cells
2014
Molecular Subtypes, Metastatic Pattern and Patient Age in Breast Cancer: An Analysis of Italian Network of Cancer Registries (AIRTUM) Data
2021
Breast cancer stage at diagnosis, patient age and molecular tumor subtype influence disease progression. The aim of this study was to analyze the relationships between these factors and survival in breast cancer patients among the Italian population using data from the AIRTUM national database. We enrolled women with primary breast cancer from 17 population-based cancer registries. Patients were subdivided into older (>69 years), middle (50–69 years) and younger age groups (<50 years) and their primary tumors categorized into four molecular subtypes based on hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) status. There were 8831 patients diagnosed betwe…
Vesiclepedia:A Compendium for Extracellular Vesicles with Continuous Community Annotation
2012
Vesiclepedia is a community-annotated compendium of molecular data on extracellular vesicles.
Long-Term Breastfeeding: The Embodied Experiences of Finnish Mothers
2019
Mothers’ experiences constitute a central and widely discussed issue within feminist breastfeeding research. Less is said however, about long-term breastfeeding in relation to embodiment. This article analyses the embodied experiences of Finnish mothers who have breastfed for over a year. Through a feminist lens, and an inductive qualitative content analysis, the written accounts of 39 long-term breastfeeding mothers were analysed, to show how mothers reflect on embodiment while breastfeeding long-term. Mothers described their embodied experiences in relation to four themes: functionality of the body; tiredness; beauty norms; and pleasure. The study reveals their accounts of bodily changes …
Bovine herpesvirus 4-based vector delivering the full length xCT DNA efficiently protects mice from mammary cancer metastases by targeting cancer ste…
2018
Despite marked advancements in its treatment, breast cancer is still the second leading cause of cancer death in women, due to relapses and distal metastases. Breast cancer stem cells (CSCs), are a cellular reservoir for recurrence, metastatic evolution and disease progression, making the development of novel therapeutics that target CSCs, and thereby inhibit metastases, an urgent need. We have previously demonstrated that the cystine-glutamate antiporter xCT (SLC7A11), a protein that was shown to be overexpressed in mammary CSCs and that plays a key role in the maintenance of their redox balance, self-renewal and resistance to chemotherapy, is a potential target for mammary cancer immunoth…