Search results for " c.c."

Metabotropic glutamate receptors activate phospholipase D in astrocytes through a protein kinase C-dependent and Rho-independent pathway.

2003

Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that mediate phospholipase D (PLD) activation in brain, but the mechanism underlying this response remains unclear. Here we used primary cultures of astrocytes as a cell model to explore the mechanism that links mGluRs to PLD. Glutamate activated both phospholipase C (PLC) and PLD with equal potency and this effect was mimicked by L-cysteinesulfinic acid, a putative neurotransmitter previously shown to activate mGluRs coupled to PLD, but not PLC, in adult brain. PLD activation by glutamate was dependent on Ca(2+) mobilization and fully blocked by both protein kinase C (PKC) inhibitors and PKC down-regulation, suggesti…

Problema o risorsa? I rifiuti, una risorsa per un design tra locale e globale

2010

Stima della fitness cardiorespiratoria (CRF) con un test "senza esercizio fisico" e associazione con indicatori convenzionali di rischio cardio-vasco…

2007

Pavement Management System model using a LCCA- microsimulation integrated approach

2014

The maintenance and the rehabilitation of the urban road pavements are not often based on systematic program and scheduling but rather on emergency or on other not identified reasons. Moreover the Life Cycle Cost Analysis (LCCA), the only peculiar procedure for the management pavement, finds its own application for highway and motorway, even if it is possible to search the best investment for the urban interstate and arterials. By the light of the quantity of the involved resources, it seems necessary to define an operative methodology for programming the maintenance and rehabilitation activities for the urban pavement. The paper is oriented towards the development of a multidisciplinary ap…

A multidisciplinary approach using LCCA and micro-simulation 10 model for the management of the urban pavements

2013

The maintenance and the rehabilitation of the urban road pavements are not often based on systematic program and scheduling but rather on emergency or on other not identified reasons. Moreover the Life Cycle Cost Analysis (LCCA), the only peculiar procedure for the management pavement, finds its own application for highway and motorway, even if it is possible to search the best investment for the urban interstate and arterials. By the light of the quantity of the involved resources, it seems necessary to define an operative methodology for programming the maintenance and rehabilitation activities for the urban pavement. The paper is oriented towards the development of a multidisciplinary ap…

The impact of weather and the phase of the rodent cycle on breeding populations of waterbirds in Finnish Lapland

2016

Climate change may affect bird populations both directly by changing the weather conditions, and indirectly through changes in the food chain. While both theoretical and empirical studies have shown climate change having drastic impacts on polar areas, its consequences on Arctic bird species are still poorly known. Here we investigated how weather and changes in predator–prey interactions affected the annual growth rates of sub-Arctic birds by monitoring the breeding numbers of three duck and seven wader species in the alpine tundra of Finnish Lapland during 2005–2015 (except for 2006). We hypothesized that growth rates of waterbirds would be positively associated with warm and dry weather …

Prenatalny okres życia człowieka

2020

Rozwój człowieka w prenatalnym okresie życia interesował ludzi już w czasach starożytności. I choć do dziś prowadzi się wiele dyskusji na temat początku ludzkiego życia, należy stwierdzić, że rozwój poczętego dziecka oraz jego kompetencje wskazują na to, że od początku swojego istnienia jest to osoba aktywna i samosterowalna, która czuje, zapamiętuje, uczy się, posiada pewien poziom świadomości. Radzi sobie z trudnościami hamującymi jego rozwój, przystosowuje do zmiennych warunków życia nie tylko wewnątrz-, ale i zewnątrzmacicznego, nabywa pewnych nawyków i przyzwyczajeń, reaguje w indywidualny, charakterystyczny dla siebie sposób

Abemaciclib: safety and effectiveness of a unique cyclin-dependent kinase inhibitor

2020

Introduction: The discovery and the clinical availability of novel cyclin-dependent kinases 4 and 6 inhibitors have profoundly changed the therapeutic scenario of metastatic hormone receptor-positive breast carcinoma. Among these inhibitors, abemaciclib can induce potent and sustained cell cycle arrest and immune system stimulation. Areas covered: This review summarizes the safety profile and clinical efficacy data on abemaciclib alone or in combination with aromatase inhibitors or fulvestrant in metastatic hormone receptor-positive breast carcinoma. The management of patients treated with abemaciclib is the object of this paper. Expert opinion: As shown in phase 2 and 3 clinical trials on …

School Staff-centered School Development by Communicative Action: Working Methods for Creating Collective Responsibility - From the Idea to Action

2020

School development is often seen as a concerted (re-)action to educational policies, curriculum development, and change in education laws or regulations, and sometimes, as stakeholders’ reactions to low school performance. Generally, school development incorporates organizational, managerial, and educational activities and measures. This is done to adapt to the new situation to achieve the desired changes and goals initiated by a given curriculum reform. In contrast, this paper focuses on school staff–driven development: It describes how teachers together with paraprofessionals contribute to school-development. Using collective responsibility creating working methods of communication, the e…

Genome wide mapping of the MBF-1 binding sites during embryogenesis of the sea urchin reveals it is a chromatin organizer.

2015

The Zinc-finger MBF1 factor is a transcription activator involved in the expression of the early histone genes during development of the sea urchin embryo (1). The DNA-binding domain of MBF1 shares high sequence similarity with that of the CTCF chromatin organizer but, unexpectedly, extensive in silico analysis failed to identify the sea urchin CTCF ortholog (2, 3). This led us to speculate that MBF1 could have co-opted the function of CTCF during evolution of the echinoderms. To support this hypothesis, we performed the genome-wide MBF1-binding sites mapping in the P. lividus genome, by chromatin immunoprecipitation coupled to next generation sequencing (ChIP-Seq). We observed that MBF1 bi…