Search results for " cc"
showing 10 items of 188 documents
Pistachio Consumption Alleviates Inflammation and Improves Gut Microbiota Composition in Mice Fed a High-Fat Diet.
2019
High-fat diet (HFD) induces inflammation and microbial dysbiosis, which are components of the metabolic syndrome. Nutritional strategies can be a valid tool to prevent metabolic and inflammatory diseases. The aim of the present study was to evaluate if the chronic intake of pistachio prevents obesity-associated inflammation and dysbiosis in HFD-fed mice. Three groups of male mice (four weeks old
Brief Report: Functional Interaction of Endoplasmic Reticulum Aminopeptidase 2 and HLA-B27 Activates the Unfolded Protein Response.
2017
Objective: The basic mechanisms underlying the pathogenesis of ankylosing spondylitis (AS) remain unresolved. We previously reported an association of the single-nucleotide polymorphism (SNP) rs2549782 in the endoplasmic reticulum aminopeptidase 2 gene (ERAP2) with AS. It is known that patients homozygous for the G allele (GG) of another ERAP2 SNP, rs2248374, lack expression of ERAP2 (ERAP2 null). The present study utilized this information to study the impact of ERAP2 deficiency on HLAâB27 expression in patients with AS, specifically focusing on the functional interaction of ERAP2 and HLAâB27 in peripheral blood mononuclear cells (PBMCs) from patients with AS and assessing the effects …
Update of the statements on biology and clinical impact of occult hepatitis B virus infection
2019
In October 2018 a large number of international experts with complementary expertise came together in Taormina to participate in a workshop on occult hepatitis B virus infection (OBI). The objectives of the workshop were to review the existing knowledge on OBI, to identify issues that require further investigation, to highlight both existing controversies and newly emerging perspectives, and ultimately to update the statements previously agreed in 2008. This paper represents the output from the workshop.
A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis.
2017
Multiple sclerosis (MS) is a human neurodegenerative disease characterized by the invasion of autoreactive T cells from the periphery into the CNS. Application of pan-histone deacetylase inhibitors (HDACi) ameliorates experimental autoimmune encephalomyelitis (EAE), an animal model for MS, suggesting that HDACi might be a potential therapeutic strategy for MS. However, the function of individual HDAC members in the pathogenesis of EAE is not known. In this study we report that mice with a T cell-specific deletion of HDAC1 (using the Cd4-Cre deleter strain; HDAC1-cKO) were completely resistant to EAE despite the ability of HDAC1cKO CD4+ T cells to differentiate into Th17 cells. RNA sequencin…
CXCL10 and CCL21 Promote Migration of Pancreatic Cancer Cells Toward Sensory Neurons and Neural Remodeling in Tumors in Mice, Associated With Pain in…
2018
Background & Aims Pancreatic ductal adenocarcinoma (PDAC) is frequently accompanied by excruciating pain, which has been associated with attraction of cancer cells and their invasion of intrapancreatic sensory nerves. Neutralization of the chemokine CCL2 reduced cancer-associated pain in a clinical trial, but there have been no systematic analyses of the highly diverse chemokine families and their receptors in PDAC. Methods We performed an open, unbiased RNA-interference screen of mammalian chemokines in co-cultures of mouse PDAC cells (K8484) and mouse peripheral sensory neurons, and confirmed findings in studies of DT8082 PDAC cells. We studied the effects of chemokines on migration of PD…
In cutaneous leishmaniasis, induction of retinoic acid in skin-derived Langerhans cells is not sufficient for induction of parasite persistence-media…
2017
Famotidine inhibits toll-like receptor 3-mediated inflammatory signaling in SARS-CoV-2 infection
2021
Apart from prevention using vaccinations, the management options for COVID-19 remain limited. In retrospective cohort studies, use of famotidine, a specific oral H2 receptor antagonist (antihistamine), has been associated with reduced risk of intubation and death in patients hospitalized with COVID-19. In a case series, nonhospitalized patients with COVID-19 experienced rapid symptom resolution after taking famotidine, but the molecular basis of these observations remains elusive. Here we show using biochemical, cellular, and functional assays that famotidine has no effect on viral replication or viral protease activity. However, famotidine can affect histamine-induced signaling processes i…
Adolescentes en conflicto con la ley. Una aproximación comunitaria: trayectorias, escenarios e itinerarios
2011
Se parte de la premisa de identificar las vulnerabilidades sociales y los procesos de exclusión de los adolescentes en conflicto con la ley, para establecer la relación entre la vulnerabilidad y la generación de trayectorias delictivas, así como su tratamiento en el escenario y su proyección al itinerario. Para dotar de coherencia este trabajo y facilitar el seguimiento de la argumentación se ha optado por dividirlo en tres partes: La primera parte comprende del capítulo primero al quinto, y concreta los fundamentos teóricos. Se inicia con la explicación del paradigma de la vulnerabilidad y exclusión social como telón de fondo del objeto investigado; continúa con las referencias históricas,…
Mujeres para el cambio : la lucha contra la pobreza en El Salvador y los impactos de la experiencia migratoria en las biografias de las mujeres salva…
2010
El presente estudio realiza un análisis de la pobreza en El Salvador con un enfoque de género y ha sido el resultado de dos fases de investigación, en las cuales se han hecho un análisis de la mujer salvadoreña que vive en el país y de las mujeres que han migrado hacia Italia. En la primera fase de investigación (Mayo 2006- Septiembre 2007) se ha realizado un análisis de la mujer salvadoreña que en el país vive en condición de pobreza, con el objetivo de valorar la importancia de la formación de capital humano femenino y el rol de la cooperación al desarrollo en la cuestión de género. El objetivo general ha sido lo de valorar desde adentro la eficacia o menos de un proyecto de desarrollo lo…
Un análisis del sistema de protección social de la Comunidad Valenciana.
2004
La tesis analiza el sistema de protección social tal como se conforma en la Comunidad Valenciana, teniendo como referencias los sistemas de otras Comunidades Autónomas, el del estado español y, siempre que ha sido posible, el marco de la Unión Europea.El enfoque adoptado para la consecución de los objetivos de la presente investigación ha tenido como marco teórico el del Estado de bienestar tal como lo entendemos hoy en día y como modelo de política social que tiene su origen en el último tercio del siglo XIX en Europa, concretamente en la Alemania de Bismarck, y que permitió superar la etapa de las políticas y leyes de Beneficencia, por las de los seguros sociales. Hoy podemos valorar esto…