Search results for " classification"
showing 10 items of 1043 documents
Clinical prioritizations and contextual constraints in nursing homes - a qualitative study
2010
Scand J Caring Sci; 2010; 24; 533–540 Clinical prioritizations and contextual constraints in nursing homes - a qualitative study Aim: The aim of the study was to describe nurses’ and physicians’ experiences of prioritization factors in nursing homes. Background: What are the experiences of health care personnel when prioritizing treatment and care for elderly residents in nursing homes? Little research has been done in this area, yet with the growing elderly population and limited health care budgets there can be little doubt about its relevance. Method: The study was conducted through semi-structured interviews with 13 physicians and nurses in six nursing homes. The interviews were anal…
Probabilistic classification of intracranial gliomas in digital microscope images based on EGFR quantity
2009
A glioma is a type of cancer occurring, in the majority of cases, in the brain. The World Health Organization (WHO) assigns a grade from I to IV to this tumor, with I being the least aggressive and IV being the most aggressive. In glioma cells of grade IV the Epidermal Growth Factor Receptors (EGFRs) are over expressed. In this paper we hypothesize that this overexpression occurs also for gliomas of grades I to III. Moreover, we present a medical study aiming to determine the correlation between the WHO classification and the EGFR quantity in glioma tissue. We define five quantity classes for EGFR. First, results of immunohistochemical staining on brain glioma slices, which visualize the EG…
Mines and quarries production: A driver analysis of withdrawals in Italy
2020
Abstract The growing demand for non-energy mineral resources has determined relevant withdrawals as well as import-export flows. This paper aims to disentangle the drivers of raw non-energy mineral resources extraction in Italy. Using a new dataset of raw resources extracted from mines and quarries in the 21 Italian regions (19 regions and 2 autonomous provinces of Trento and Bolzano) for the period 2013–2016, our empirical analysis confirms the relevance of mining and quarrying producer price index as well as the manufacturing and construction sectors as main drivers. In line with the Hotelling (1931)'s theory, a positive relationship between m&q mineral resources extraction intensity and …
The Use of Rule-Based and QSPR Approaches in ADME Profiling: A Case Study on Caco-2 Permeability.
2013
During the early ADME profiling the development of simple, interpretable and reliable in silico tools is very important. In this study, rule-based and QSPR approaches were investigated using a large Caco-2 permeability database. Three permeability classes were determined: high (H), moderate (M) and low (L). The main physicochemical properties related with permeability were ranked as follows: Polar Surface Area (PSA)>Lipophilicity (logP/logD)>Molecular Weight (MW)>number of Hydrogen Bond donors and acceptors>Ionization State>number of Rotatable Bonds>number of Rings. The best rule, based on the combination of PSA-MW-logD (3PRule), was able to identify the H, M and L classes with accuracy of …
Enteroviruses and coronaviruses: similarities and therapeutic targets
2021
ABSTRACT Introduction: Enteroviruses are common viruses causing a huge number of acute and chronic infections and producing towering economic costs. Similarly, coronaviruses cause seasonal mild infections, epidemics, and even pandemics and can lead to severe respiratory symptoms. It is important to develop broadly acting antiviral molecules to efficiently tackle the infections caused by thes. Areas covered: This review illuminates the differences and similarities between enteroviruses and coronaviruses and examines the most appealing therapeutic targets to combat both virus groups. Publications of both virus groups and deposited structures discovered through PubMed to March 2021 for viral p…
A novel approach to investigate the evolution of structured tandem repeat protein families by exon duplication.
2020
Tandem Repeat Proteins (TRPs) are ubiquitous in cells and are enriched in eukaryotes. They contributed to the evolution of organism complexity, specializing for functions that require quick adaptability such as immunity-related functions. To investigate the hypothesis of repeat protein evolution through exon duplication and rearrangement, we designed a tool to analyze the relationships between exon/intron patterns and structural symmetries. The tool allows comparison of the structure fragments as defined by exon/intron boundaries from Ensembl against the structural element repetitions from RepeatsDB. The all-against-all pairwise structural alignment between fragments and comparison of the t…
A parts-per-billion measurement of the antiproton magnetic moment
2017
The magnetic moment of the antiproton is measured at the parts-per-billion level, improving on previous measurements by a factor of about 350. Comparing the fundamental properties of normal-matter particles with their antimatter counterparts tests charge–parity–time (CPT) invariance, which is an important part of the standard model of particle physics. Many properties have been measured to the parts-per-billion level of uncertainty, but the magnetic moment of the antiproton has not. Christian Smorra and colleagues have now done so, and report that it is −2.7928473441 ± 0.0000000042 in units of the nuclear magneton. This is consistent with the magnetic moment of the proton, 2.792847350 ± 0.0…
Current Practices in the Management of Pulmonary Ground-Glass Opacities: A Survey of SICT Members
2018
Background Several gray areas and controversies exist concerning the management of pulmonary ground-glass opacities (GGOs), and there is a lack of consensus among clinicians on this topic. One of the main aims of the Italian Society of Thoracic Surgery is to promote education and research, so we decided to perform a survey on this topic to estimate current trends in practice in a large sample of thoracic surgeons. Methods A total of 160 thoracic surgeons responded, namely, completed our questionnaire (response rate, 53%; 160 of 302). The survey was composed of 36 questions divided into six subsections: (1) demographic characteristics of the respondents; (2) terminology and taxonomy; (3) rad…
Sleep HERMES: a European training project for respiratory sleep medicine
2011
The clinical characterisation and description of the obstructive sleep apnoea/hypopnoea syndrome (OSAHS) and related syndromes have been revealed by several epidemiological studies conducted in the late 20th and 21st centuries. These highly prevalent syndromes affect about 9% of middle-aged males and 4% of females. These syndromes have serious medical and social consequences, such as cardiovascular or metabolic diseases and even premature death. Consequently, respiratory sleep medicine has evolved and progressed rapidly within the sleep medicine field over the last decades. New diagnostic and therapeutic techniques appeared in response to an increasing number of patients and clinical interv…
The 2021 WHO Classification of Tumors of the Thymus and Mediastinum: What Is New in Thymic Epithelial, Germ Cell, and Mesenchymal Tumors?
2022
Abstract This overview of the fifth edition of the WHO classification of thymic epithelial tumors (including thymomas, thymic carcinomas, and thymic neuroendocrine tumors [NETs]), mediastinal germ cell tumors, and mesenchymal neoplasms aims to (1) list established and new tumor entities and subtypes and (2) focus on diagnostic, molecular, and conceptual advances since publication of the fourth edition in 2015. Diagnostic advances are best exemplified by the immunohistochemical characterization of adenocarcinomas and the recognition of genetic translocations in metaplastic thymomas, rare B2 and B3 thymomas, and hyalinizing clear cell carcinomas. Advancements at the molecular and tumor biolog…