Search results for " colon."
showing 10 items of 710 documents
Artico nero. La lunga notte dei popoli dei ghiacci
2016
Sette storie da un Artico nero e morente, ambientate in Canada, nella Norvegia settentrionale, in Siberia, in Groenlandia: luoghi dove la distruzione di una cultura sta anticipando gli scenari peggiori. Un’analisi politica e sociale incassata nel modello romanzo-saggio. Un modo nuovo di raccontare e fare antropologia: antropofiction.
Égalité et citoyenneté en Algérie et dans les établissements français de l'Inde au milieu du XIXe siècle
2008
Dans les colonies françaises d'Algérie et des établissements de l'Inde du XIXe siècle, la société était totalement différente de celle des « quatre vieilles colonies » : elle comportait des communautés identifiables, avec des droits locaux ; les habitants étaient régis par un statut juridique déterminé en fonction de leur religion. Ces statuts personnels des indigènes – terme pris dans son sens large et non dans celui du code de l'indigénat – étaient incompatibles avec le Code civil sans adaptation. Par ailleurs, l'organisation locale, en castes pour les hindous, en tribus pour l'Algérie, étaient également bien éloignées des institutions françaises. L'acculturation juridique était donc néce…
The insufficiencies of legal assimilation for economic and social integration in the French colonies in the 19th century
2007
Communication at the Center of social History of the 20th century, University of Paris 1 Pantheon-Sorbonne, Malher Center, June 22-23 2001 (The legacy of Colonization and Decolonization in Europe and the Americas); The case of the inhabitants of the French colonies in 19th century shows the importance but also the insufficiency of legal assimilation for economic and social integration. The evolution of the legal statute of colored men, free, freed and slaves, reveals the assimilationnist or segregationist intent of the different regimes. The principle of colonization (preservation of the colonies, or even colonial expansion) was widely accepted in 19th century. It was not called into questi…
Ethanol promotes survival and tumor progression of colon cancer cells
2018
In the Western Countries, colon cancer is the third tumor for aggressiveness and incidence after lung and breast/prostate cancer. Different risk factors concur to the development of colon cancer, including genetic factors, inflammation, intestinal microflora composition, as well as lifestyle. Epidemiologic studies correlating alcohol consumption and assert that the risks are 5-fold higher among drinkers compared to nondrinkers. However, the exact mechanisms correlating heavy alcohol drinking and colon cancer are not completely elucidated yet. To shed light on the biochemical mechanisms through which alcohol favors colon cancer progression, we evaluated the effect of high doses of ethanol (1…
Three New Medicagenic Acid Saponins from Polygala micranthaGuill. & Perr.
2011
Three new medicagenic acid saponins, micranthosides A–C (1–3), were isolated from the roots of Polygala micranthaGuill. & Perr., along with six known presenegenin saponins. Their structures were elucidated on the basis of extensive 1D- and 2D-NMR experiments (1H, 13C, DEPT, COSY, TOCSY, NOESY, HSQC, and HMBC) and mass spectrometry as 3-O-β-D-glucopyranosylmedicagenic acid 28-[O-β-D-galactopyranosyl-(14)-O-β-D-xylopyranosyl-(14)-O-α-L-rhamnopyranosyl-(12)-β-D-fucopyranosyl] ester (1), 3-O-β-D-glucopyranosylmedicagenic acid 28-[O-6-O-acetyl-β-D-galactopyranosyl-(14)-O-β-D-xylopyranosyl-(14)-O-α-L-rhamnopyranosyl-(12)-β-D-fucopyranosyl] ester (2), and 3-O-{O-β-D-glucopyranosyl-(13)-O-[β-D-gluc…
Tecnologías de secuenciación masiva y PCR digital en la detección de ADN tumoral procedente de tejido y plasma en pacientes de colon localizado
2022
El cáncer de colon se sitúa como uno de los tumores más relevantes a nivel social, con una tasa de entre el 30 y 50% de recaídas tras la resección. Como herramienta de estudio en este tumor, la biopsia líquida se ha abierto paso en diferentes ámbitos, tales como la detección de la heterogeneidad tumoral o la enfermedad mínima residual (EMR). El fundamento de esta estrategia es detectar el ADN tumoral circulante (ctDNA), que se encuentra diluido en el ADN libre circulante (cfDNA), siendo necesario el uso de tecnologías aptas para la detección a frecuencias bajo el 1%. La hipótesis de esta tesis se apoya en variantes somáticas para detectar el ctDNA y definir la heterogeneidad tumoral, la EMR…
EFFICACY OF ZOLEDRONIC ACID IN PATIENTS WITH COLORECTAL CANCER METASTATIC TO BONE
2010
Introduction. Bone metastases are an emerging clinical problem in colorectal cancer patients probably related to survival increase. There are no data in literature about the role of BPs in the treatment of bone disease from colorectal cancer. We present the final data of a large Italian multicenter retrospective analysis. Methods. 264 colorectal cancer patients with occurrence of bone metastases have been included in the study. All patients were dead due to cancer at the moment of the study inclusion. Patients characteristics, Skeletal Related Events (SRE) data and median survival after bone metastases appearance have been collected in a master data base and statistically analyzed. The prim…
Damage identification by Lévy ant colony optimization
2010
This paper deals with the identification of incipient damage in structural elements by non-destructive test based on experimentally measured structural dynamical response. By applycation of the Hilbert transform to the recorded signal the so-called phase of the analytical signal is recovered and a proper functional is constructed in such a way that its global minimum gives a measure of the damage level, meant as stiffness reduction. Minimization is achieved by applying a modified Ant Colony Optimization (ACO) for continuous variables, inspired by the ants’ forageing behavior. The modification consists in the application of a new perturbation operator, based on alpha stable Lévy distribution…
Hematopoietic Stem Cell Mobilization for Gene Therapy: The Combination of G-CSF+Plerixafor in Patients with Beta-Thalassemia Major Provides High Yiel…
2015
Abstract Hematopoietic stem cell engineering is a promising therapy to cure b-thalassemia, in particular for patients who lack a suitable BM donor for allogeneic transplantation. Since the engrafted gene-corrected stem cells will not have any selective advantage over the unmodified ones, the effectiveness of the therapy in this setting largely depends on the infusion of high numbers of gene-modified cells and on the conditioning regimen. The quality of the infused cells is also crucial for the clinical outcome and the duration of the therapeutic effect. HSPCs mobilization, particularly when G-CSF and plerixafor are used in combination, has been proved to be the optimal approach to harvest a…
B cells assume the command
2015
A proinflammatory B cell cytokine activates autoimmunity, and B cell depletion treats multiple sclerosis (Li et al., this issue).