Search results for " colore."
showing 10 items of 234 documents
Il bianco e l'oro
2019
Giacomo Serpotta (1656-1732) was a brilliant and highly skilled master of the sculptural art of stucco throughout Europe. He was born in poverty in Palermo, and his father was imprisoned shortly after he was born. The canonical critic and historian Antonio Mongitore praised him for his work and for his confident and almost frantic style of drawing, and for his considerable dilicatezza (sensitivity). He defined Serpottaan“outstandingstuccoist”.Asimilaropinion comes from abbot Gioacchino Di Marzo, who greatly praised Serpotta in his essential essay entitled “The Gaginis and sculpture in Sicily”, published in 1980, and recognised the undoubted influence of the Gagini school, which began with h…
Expression of a specific Thymidylate synthase polimorfic allele in metastatic colorectal patients is regulated by Myeloid Zinc Finger 1.
2013
Thymidylate Synthase (TS) is the target enzyme for fluoropyrimidine anticancer drugs. Its expression is regulated by the number of functional upstream stimulatory factor (USF) E box consensus elements present on its 5’ untranslated region. To date are known different polymorphisms, the first one consisting of 2 or 3 repeat of a 28 bp sequence, a further single nucleotide polymorphism (SNP) consisting in a G>C substitution within the second repeat of 3R (3RG>3RC) and recently it has been identified an additional SNP a G>C substitution at the 12th nucleotide in the first repeat of the 2R allele (2RG>2RC). These polymorphisms can influence TS expression, in particular 3R/3R genotype and the pr…
Analysis of UGT1A1*28 and DPYD*2A polymorphisms in Sicilians patients with metastatic colorectal cancer treated with Irinotecan and 5-fluorouracil.
2013
Expression of angiogenic regulators. VEGF and leptin, is regulated by the EGF/P13K/STAT3 pathway in colorectal cancer cells
2009
Myeloid zinc finger 1 regulates thymidylate synthase expression in patients with metastatic colorectal cancer showing the same promoter gene polymorp…
2011
Le razze umane non esistono, lo dimostra…. il colore della pelle!
2015
Alcune manifestazioni fenotipiche della specie umana sono tramandate di generazione in generazione secondo delle regole che apparentemente non seguono le classiche leggi di Mendel: sono i caratteri continui, un tipo particolare di ereditarietà in cui ha molta influenza l’ambiente ed anche le sue interazioni con il genoma. Solo per questi tipi particolari di caratteri è possibile definire due grandezze, l’ereditabilità e la varianza, che danno una misura di quanta sia la componente genetica e di quanto quella ambientale nella loro definizione. Studi di correlazione fra persone non imparentate e gemelli monozigoti hanno dimostrato che il carattere continuo umano “creste digitali” ha un alto v…
Graphene oxide containing hyaluronic acid based nanogels for the potential treatment of colorectal cancer
2017
Here, we reported the production of graphene oxide (GO) containing nanogels produced by a top-down procedure employing as a starting biomaterial an amino derivative of hyaluronic acid named HA-EDA. This derivative was reacted, in the presence of single layer GO, with α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide-((2-aminoethyl)-carbamate)-divinyl sulfone (PHEA-DVS) employed as a macromolecular crosslinking agent. The so obtained hydrogel was homogenized by ultra-turrax and high pressure homogenizer and nanogels with Z-average of 390 nm and PDI of 0.22 were obtained. These nanogels were employed to incorporate Irinotecan (IT), an antitumor drug used in the treatment of colorectal carcinoma. It …
Role of the colored noise in a FitzHugh-Nagumo system driven by a periodic signal
2007
During these last years the interest in neuronal dynamics increased. The study of this kind of system has been carried out by using the FitzHugh-Nagumo (FHN) model that is a simplified modification of the Hodgkin-Huxley model. Many interesting phenomena can be observed in the presence of fluctuations: modification of detection threshold by manipulation of noisy parameters (FHN model), noise-induced activation and coeherence resonance for suitable noise amplitude (absence of periodic signal), resonant activation for high periodic signals and noise reduction, intrinsic stochastic resonance (ISR) in Hodgkin-Huxley neuron and the enhancement of a weak signal by tuning the subthreshold intrinsic…
The prognostic role of KRAS and BRAF in patients undergoing surgical resection of colorectal cancer liver metastasis: a systematic review and meta-an…
2016
Background: Clinical trials investigated the potential role of both KRAS and BRAF mutations, as prognostic biomarkers, in colorectal cancer (CRC) patients who underwent surgical treatment of liver metastasis (CLM), showing conflicting results. This meta-analysis aims to review all the studies reporting survival outcomes (recurrence free survival (RFS), and/or overall survival (OS)) of patients undergoing resection of CLM, stratified according to KRAS and/or BRAF mutation status. Materials and Methods: Data from all published studies reporting survival outcomes (RFS and/or OS) of CRC patients who received resection of CLM, stratified by KRAS and/or BRAF mutation status were collected by sear…