Search results for " confinement."

Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion

2021

Although mutations leading to a compromised nuclear envelope cause diseases such as muscular dystrophies or accelerated aging, the consequences of mechanically induced nuclear envelope ruptures are less known. Here, we show that nuclear envelope ruptures induce DNA damage that promotes senescence in non-transformed cells and induces an invasive phenotype in human breast cancer cells. We find that the endoplasmic reticulum (ER)-associated exonuclease TREX1 translocates into the nucleus after nuclear envelope rupture and is required to induce DNA damage. Inside the mammary duct, cellular crowding leads to nuclear envelope ruptures that generate TREX1-dependent DNA damage, thereby driving the …

COVID-19, Gender Housework Division and Municipality Size in Spain

2022

The COVID-19 health crisis brought with it an increase in the workload on family members due to the restriction of services and the suspension of formal and informal care networks. Numerous studies have analyzed how home confinement have affected different gender gaps, including the gender gap related to chores within the home. This research aims to contribute to the existing literature from the perspective of gender geography by introducing the variable municipality size in the analyses. Our research in the case of Spain shows the COVID-19 health crisis to have had a significant impact on gender gaps, albeit to varying degrees. Women, especially those living in small municipalities, experi…

A Theoretical Model to Evaluate the Compressive Behaviour of RС Jacketed Columns

2016

Reinforced concrete (RC) jacketing is becoming increasingly common among the different retrofit techniques for poor RC members, due to its economical and practical advantages. Experimental investigations in the literature have shown that the actual axial capacity of RC jacketed members can be substantially lower than that analytically evaluated by adapting the most common theoretical models for confined concrete. This fact can be explained by taking into account the presence of tensile stresses developing in the concrete, due to a mutual interaction between the inner core and the external jacket. This phenomenon is relevant especially in members where the concrete properties of the jacket a…

Compressive response of concrete columns under service conditions strengthened by confining devices: from the local to the global behavior.

Il rinforzo di colonne in calcestruzzo armato tramite materiali polimerici fibrorinforzati (FRP) o tramite incamiciature in acciaio conferisce agli elementi strutturali degli edifici esistenti un elevato incremento di capacità portante e deformativa grazie alle proprietà dei materiali che svolgono la funzione di confinamento. Conoscere adeguatamente le proprietà meccaniche degli elementi in calcestruzzo confinato risulta di fondamentale importanza nell’ambito di un progetto di sistemi di rinforzo strutturale. Tuttavia, le normative attualmente vigenti non forniscono prescrizioni su come tenere in considerazione la presenza dei carichi di esercizio sugli elementi strutturali al momento dell’…

A Handy Stress-Strain Law for FRP Confined Concrete

2006

Performance Assessment of Basalt FRCM for the Confinement of Clay Brick Masonry Cylinders

2021

Fibre Reinforced Cementitious Matrix (FRCM) composites have been proved to be a suitable strengthening material for masonry structures in the last years. Moreover, basalt fibres are increasingly used as reinforcement of composites as a more sustainable alternative to glass fibres. The goal of this work is to investigate the effectiveness of basalt FRCM to confine masonry circular columns. A total of eighteen clay brick masonry cylinders were tested in compression. The specimens were cored from two different masonry assemblies and wrapped with one or two layers of BFRCM composite. The stress-strain curves and the gains of strength and strain capacity of confined cylinders compared to the con…

Flexural behaviour of RC columns strengthened with steel angles and strips

2011

Cyclic axial testing of columns confined with Fiber Reinforced Cementitious Matrix

2012

A simplified method for ductility calculation in RC jacketed columns

2015

Reinforced concrete (RC) jacketing is a common method to retrofit existing columns with poor structural performance. It can be applied in two different ways: if the continuity of the jacket is ensured, the axial load of the column can be transferred to the jacket, which will be directly loaded; conversely, if no continuity is provided, the jacket induces only confinement action. In both cases the strength and ductility evaluation is rather complex, due to the different physical phenomena included, such as confinement, composite action core-jacket, preload, buckling of longitudinal bars. Although different theoretical studies have been carried out to calculate the confinement effects, a prac…

An experimental study on the compressive behaviour of calcarenite masonry columns wrapped by fiber reinforced mortar wraps

2018

The use of Fiber Reinforced Cementitious Mortar (FRCM) systems for structural retrofitting of masonry structures has become increasingly popular in the last years, due to the capability of this technique in overcoming some of the drawbacks related to the adoption of resin-based composites. In fact, FRCM systems ensure good compatibility between the reinforcing layers and the substrate, achieving also the removability requirement, which is of fundamental importance for historical constructions. Recent research studies focused on the mechanical performance of FRCM materials, by studying its tensile behaviour and bond between the strengthening layer and masonry, pointing out as failure is alwa…