Search results for " coordination"
showing 10 items of 215 documents
Cerebellar granule-cell-specific GABAAreceptors attenuate benzodiazepine-induced ataxia: evidence from α6-subunit-deficient mice
1999
Benzodiazepine- and alcohol-induced ataxias in rodents have been proposed to be affected by the gamma-aminobutyric acid type A (GABAA) receptor alpha 6 subunit, which contributes to receptors specifically expressed in cerebellar granule cells. We have studied an alpha 6 -/- mouse line for motor performance and drug sensitivity. These mice, as a result of a specific genetic lesion, carry a precise impairment at their Golgi-granule cell synapses. On motor performance tests (rotarod, horizontal wire, pole descending, staircase and swimming tests) there were no robust baseline differences in motor function or motor learning between alpha 6 -/- and alpha 6 +/+ mice. On the rotarod test, however,…
Trajectories of motor coordination in 4–7-years-old children: A latent growth curve analysis
2014
Introduction For being able to take part in physical activities typical to the given age, children need proficiency in several motor tasks. Gross motor coordination (MC) is a basis for executing motor tasks and for learning new movement patterns. This study aimed to identify different MC trajectories in children aged 4–7-years-old. Methods Motor coordination of children ( n = 94, mean age 6.1 ± 1.3 years at baseline) was measured at 0, 6 and 12 months by KTK-test battery [1] . To identify different MC trajectories, developmental trend of the mean score of KTK was analyzed by using a latent growth curve and growth mixture analysis. Results In general, MC developed significantly over the yea…
Can bureaucrats order public health? The case of Norway
2013
Introduction: The implementation of a new structural reform, the Coordination Reform, prioritizing a new public health agenda, was initiated to develop a more decentralized, integrated health care system in Norway in 2012. The same year, new health legislation was implemented and due to the new Public Health Act the responsibility for implementing a new public health agenda was decentralized to the local level. Historically, due to lack of funding – these issues have got low priority among local authorities. The new public health legislation reflects a shift in policy focus from treatment to illness prevention – where planning and partnership among primary end specialist health care, as wel…
Effectiveness and safety of Nintendo Wii Fit PlusTM training in children with migraine without aura a preliminary study
2013
Maria Esposito,1 Maria Ruberto,2 Francesca Gimigliano,1,2 Rosa Marotta,3 Beatrice Gallai,4 Lucia Parisi,5 Serena Marianna Lavano,3 Michele Roccella,5 Marco Carotenuto11Center for Childhood Headache, Child and Adolescent Neuropsychiatry Clinic, Department of Mental Health, Physical and Preventive Medicine, 2Department of Odonto-Stomathologic Disciplines, Pathology – Orthopedic Sciences, Second University of Naples, Naples, Italy; 3Department of Psychiatry, “Magna Graecia” University of Catanzaro, Catanzaro, Italy; 4Unit of Child and Adolescent Neuropsychiatry, University of Perugia, Perugia, Italy; 5Child Neuropsychiatry, Department of Psychology, University of …
Transitions between care settings after enrollment in a palliative care service in Italy: a retrospective analysis.
2013
This study was a retrospective analysis of prospectively collected data that aimed to map patients’ care transitions following admission to a specialist palliative care service in Italy called Antea Centre. Patients’ data was extracted from the Antea local database from 2007 to 2011. External transitions were defined as a change in the setting of care, with the patient no longer being cared for by Antea staff. Internal transitions were defined as a change in the setting of care, with the care still being provided by Antea staff. A total of 1123 patients out of 5313 admitted to the palliative service (21%) experienced transitions. Patients who experienced no transitions after their admissio…
Differences in the Motor Coordination Abilities Among Adolescent Gymnasts, Swimmers, and Ice Hockey Players
2017
AbstractPurpose. Motor coordination is proposed to be a relatively stable age-related construct, unlikely to be influenced by aligned experiential factors such as intensive sport-specific training. The purpose of the study is to investigate if there are differences in motor coordination abilities among young artistic gymnasts, swimmers, and ice hockey players.Methods. The participants of the study were 508 female and 258 male adolescents (age, M = 12.80, SD = 1.10) comprising artistic gymnasts (n = 463), swimmers (n = 70), and ice hockey players (n = 233). The KTK-test protocol was used to analyse their gross motor coordination abilities.Results. The results of the study demonstrated that g…
Phosphorus-Chalcogen Ring Expansion and Metal Coordination
2017
The reactivity of 4-membered (RPCh)2 rings (Ch = S, Se) that contain phosphorus in the +3 oxidation state is reported. These compounds undergo ring expansion to (RPCh)3 with the addition of a Lewis base. The 6-membered rings were found to be more stable than the 4-membered precursors, and the mechanism of their formation was investigated experimentally and by density functional theory calculations. The computational work identified two plausible mechanisms involving a phosphinidene chalcogenide intermediate, either as a free species or stabilized by a suitable base. Both the 4- and 6-membered rings were found to react with coinage metals, giving the same products: (RPCh)3 rings bound to the…
CH vs. HC—Promiscuous Metal Sponges in Antimicrobial Peptides and Metallophores
2023
Histidine and cysteine residues, with their imidazole and thiol moieties that deprotonate at approximately physiological pH values, are primary binding sites for Zn(II), Ni(II) and Fe(II) ions and are thus ubiquitous both in peptidic metallophores and in antimicrobial peptides that may use nutritional immunity as a way to limit pathogenicity during infection. We focus on metal complex solution equilibria of model sequences encompassing Cys–His and His–Cys motifs, showing that the position of histidine and cysteine residues in the sequence has a crucial impact on its coordination properties. CH and HC motifs occur as many as 411 times in the antimicrobial peptide database, while …
Zn2+ and Cu2+ complexes of a fluorescent scorpiand-type oxadiazole azamacrocyclic ligand: crystal structures, solution studies and optical properties
2020
A ligand comprised of a macrocyclic pyridinophane core having a pendant arm containing a secondary amine group linked through a methylene spacer to a pyridyl–oxadiazole–phenyl (PyPD) fluorescent system has been prepared (L). The crystal structures of [ZnL](ClO4)2 and [CuL](ClO4)2 show that M2+ is coordinated to all the nitrogen atoms of the macrocyclic core, the secondary amine of the pendant arm and the nitrogen atom of the pyridine group of the fluorescent moiety, the latter bond being clearly weaker than the one with the pyridine of the macrocycle. Solution studies showed the formation of a highly stable Cu2+ complex with 1 : 1 stoichiometry, whereas with Zn2+ least stable complexes were…
Motoriikan havainnointilomake (MOQ-T) suomalaisille opettajille - Motor Observation Questionnaire for Teachers -lomakkeen kulttuurinen kääntäminen
2015
Motorisen oppimisen vaikeuksia kuvaava termistö on hyvin kirjavaa. Suomessa ongelmien diagnosoinnissa käytetään käsitteitä kehityksellinen koordinaatiohäiriö ja motoriikan kehityshäiriö. Lapsia, joilla on motorisen oppimisen ongelmia, arvioidaan olevan noin 5–6 prosenttia ikäluokasta; jokaisessa koululuokassa on siis keskimäärin yksi oppilas, joka tarvitsee motoriseen oppimiseensa tukea. Vaikka häiriö on yleinen, liikuntaa opettavilta opettajilta puuttuu työkalut motoriikan oppimisvaikeuden tunnistamiseen kouluympäristössä. Tämän tutkimuksen tarkoituksena oli tehdä kulttuurinen käännös hollantilaisesta opettajille kehitetystä Motor Observation Questionnaire for Teachers (MOQ-T) -lomakkeesta…