Search results for " cost"
showing 10 items of 3966 documents
Prioritization of high-cost new drugs for HCV: making sustainability ethical
2016
Hepatitis C virus (HCV) infection is a major health problem worldwide. Chronic HCV infection may in the long run cause cirrhosis, hepatic decompensation and hepatocellular carcinoma, with an ultimate disease burden of at least 350,000 deaths per year worldwide. The new generation of highly effective direct acting antivirals (DAA) to treat HCV infection brings major promises to infected patients in terms of exceedingly high rates of sustained virological response (SVR) but also of tolerability, allowing even the sickest patients to be treated. Even in the face of the excellent safety and efficacy and wide theoretical applicability of these regimens, their introduction is currently facing cos…
Il Potere costituente. La teoria politica federalista di Carl J. Friedrich e l'occasione europea.
2009
The essay is made by two main aspects: history of European political Institutions, and federal political theory. For the first aspect, the author focuses on a special moment of Europe when the partners tried to have an agreement for a common military defence, the first step for the political union of Europe. So that European Commission asked the qualified opinion of the major political theorist, Carl J. Friedrich, a prominent expert of federalism and constitutionalism.
Il Castello Maniace di Siracusa. Stereotomia e tecniche costruttive nell’architettura del Mediterraneo
2011
L’enigma del castello Maniace di Siracusa, realizzato nella prima metà del XIII secolo per volontà dell’imperatore Federico II, ruota intorno all’immensa sala colonnare, alla sua funzione e ai criteri costruttivi adottati per edificarla. L’autrice ha avuto l’opportunità di studiare capillarmente la fabbrica, assumendo una conoscenza materica diretta, grazie alla lunga frequentazione, resa possibile dal cantiere di restauro che ha recentemente restituito il “monumento” alla fruizione pubblica. Queste informazioni sono state utilizzate per verificare le diverse letture e ipotesi sinora formulate e l’indagine procede a partire dalla densa serie di quesiti inevasi. Di fronte a una architettura …
Hospital and outpatient models for Hematopoietic Stem Cell Transplantation: A systematic review of comparative studies for health outcomes, experienc…
2021
The number of Hematopoietic Stem Cell Transplantations has risen in the past 20 years. The practice of outpatient Hematopoietic Stem Cell Transplantation programs is increasing in an attempt to improve the quality of patient care and reduce the demand for hospital admission. A systematic review of 29 comparative studies between in-hospital and outpatient treatment of Hematopoietic Stem Cell Transplantation, with no restriction by outpatient regime was conducted. This study aims to analyse the current evidence on the effects of the outpatient model on patient-centred outcomes, comparing both in-hospital and outpatient models for autologous and allogeneic HSCT using the Triple Aim framework: …
Pumice powder as filler of self-compacting concrete
2015
Abstract An experimental study on the rheological and mechanical properties of self-compacting concrete with pumice powder used as filler additive is presented. Self-compacting concrete (SCC) shows its peculiar characteristics in the fresh state and many researches have been developed with reference to its rheological characteristics paying attention to the techniques of self-compacting properties assessment. One of the most important aspect in concrete mix-design is the type and the amount of fillers with respect to water and cement: this amount has great influence not only on self-compacting properties (fluidity, segregation, etc.), but also on the mechanical properties of the mixture. Vo…
Experimental results of RC columns strengthnened with Fiber Reinforced Cementitious Mortars
2012
The structural behaviour of reinforced concrete columns strengthened with a system made up of fibre nets embedded in an inorganic stabilized cementitious matrix was investigated. Specimens with circular and square cross-section were cast and subjected to monotonic uniaxial compression to investigate the efficiency of a Polypara-phenylene-benzo-bisthiazole (PBO) Fibre Reinforced Cementitious Mortars (FRCM) system in increasing both carrying capacity and ductility. The experimental results show that confinement with PBO fibre produced a noticeable increment in strength and ductility, though the low mechanical ratios of fibre considered were not always able to ensure hardening behaviour up to …
Analysing Incentive Strategies to Promote Participation in Crowdsourcing Systems
2016
In this paper, we define two strategies for crowdsourcing systems to encourage users to participate at a cost that is close to the optimal cost for the system. In the scenario considered, the system has temporal constraints and potential participants have dynamic behaviors related to the expected rewards (i.e., users’ expected rewards in exchange of their contributions change over time). We propose and evaluate two types of strategies that promote participation of users through monetary rewards that can change as time passes in order to adapt them to the population dynamic behaviors.
On the use of fractional calculus for the probabilistic characterization of random variables
2009
In this paper, the classical problem of the probabilistic characterization of a random variable is re-examined. A random variable is usually described by the probability density function (PDF) or by its Fourier transform, namely the characteristic function (CF). The CF can be further expressed by a Taylor series involving the moments of the random variable. However, in some circumstances, the moments do not exist and the Taylor expansion of the CF is useless. This happens for example in the case of $\alpha$--stable random variables. Here, the problem of representing the CF or the PDF of random variables (r.vs) is examined by introducing fractional calculus. Two very remarkable results are o…
Path integral solution for non-linear system enforced by Poisson White Noise
2008
Abstract In this paper the response in terms of probability density function of non-linear systems under Poisson White Noise is considered. The problem is handled via path integral (PI) solution that may be considered as a step-by-step solution technique in terms of probability density function. First the extension of the PI to the case of Poisson White Noise is derived, then it is shown that at the limit when the time step becomes an infinitesimal quantity the Kolmogorov–Feller (K–F) equation is fully restored enforcing the validity of the approximations made in obtaining the conditional probability appearing in the Chapman Kolmogorov equation (starting point of the PI). Spectral counterpa…
Probabilistic response of nonlinear systems under combined normal and Poisson white noise via path integral method
2011
In this paper the response in terms of probability density function of nonlinear systems under combined normal and Poisson white noise is considered. The problem is handled via a Path Integral Solution (PIS) that may be considered as a step-by-step solution technique in terms of probability density function. A nonlinear system under normal white noise, Poissonian white noise and under the superposition of normal and Poisson white noise is performed through PIS. The spectral counterpart of the PIS, ruling the evolution of the characteristic functions is also derived. It is shown that at the limit when the time step becomes an infinitesimal quantity an equation ruling the evolution of the pro…