Search results for " culturali"

A Fuzzy Logic C-Means Clustering Algorithm to Enhance Microcalcifications Clusters in Digital Mammograms

2011

The detection of microcalcifications is a hard task, since they are quite small and often poorly contrasted against the background of images. The Computer Aided Detection (CAD) systems could be very useful for breast cancer control. In this paper, we report a method to enhance microcalcifications cluster in digital mammograms. A Fuzzy Logic clustering algorithm with a set of features is used for clustering microcalcifications. The method described was tested on simulated clusters of microcalcifications, so that the location of the cluster within the breast and the exact number of microcalcifications is known.

DOSIMETRIA ESR CON ALANINA PER ADRONTERAPIA CON IONI CARBONIO

2015

La sicurezza del paziente sottoposto a trattamenti terapeutici con radiazioni ionizzanti e il buon esito degli ultimi sono strettamente legati all’ottimizzazione delle procedure di esposizione alle radiazioni ionizzanti. In particolare è fondamentale arrecare il danno minore possibile ai tessuti sani che circondano la neoplasia da trattare. Rispetto ai campi di radiazione convenzionali utilizzati in radioterapia (fotoni), le particelle cariche pesanti (protoni e ioni carbonio) offrono diversi vantaggi quali la bassa dispersione laterale, l’alta efficacia biologica (RBE) nella regione del picco di Bragg ed un profilo di dose caratteristico in profondità del tutto differente da quello dei fot…

Dal colore alla caratterizzazione ottica di pigmenti antichi: validità del metodo spettrofotometrico e Teoria di Itten

2014

METODI FISICO E BIOLOGICO DI IDENTIFICAZIONE DI ALIMENTI IRRADIATI CONTENENTI CELLULOSA ATTRAVERSO L'USO DELLA DNA COMET ASSAY E DELLE SPETTROSCOPIA …

2013

Tracking the structural dynamics of proteins in solution using time-resolved wide-angle X-ray scattering (vol 5, pg 881, 2008)

2008

Tracking Ca2+ ATPase intermediates in real time by x-ray solution scattering

2020

Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) transporters regulate calcium signaling by active calcium ion reuptake to internal stores. Structural transitions associated with transport have been characterized by x-ray crystallography, but critical intermediates involved in the accessibility switch across the membrane are missing. We combined time-resolved x-ray solution scattering (TR-XSS) experiments and molecular dynamics (MD) simulations for real-time tracking of concerted SERCA reaction cycle dynamics in the native membrane. The equilibrium [Ca2] E1 state before laser activation differed in the domain arrangement compared with crystal structures, and following laser-induced release o…

Pulse EPR methods for studying chemical and biological samples containing transition metals

2006

This review discusses the application of pulse EPR to the characterization of disordered systems, with an emphasis on samples containing transition metals. Electron nuclear double-resonance (ENDOR), electron-spin-echo envelope-modulation (ESEEM), and double electron-electron resonance (DEER) methodologies are outlined. The theory of field modulation is outlined, and its application is illustrated with DEER experiments. The simulation of powder spectra in EPR is discussed, and strategies for optimization are given. The implementation of this armory of techniques is demonstrated on a rich variety of chemical systems: several porphyrin derivatives that are found in proteins and used as model s…

Influence of metal ions on thermal aggregation of bovine serum albumin: aggregation kinetics and structural changes

2009

Metal ions are implicated in protein aggregation processes of several neurodegenerative pathologies. In this work the effects of Cu(II) and Zn(II) ions on heat-induced structural modifications of bovine serum albumin (BSA) were studied, with the aim of delineating the role of these ions in the early stages of proteins aggregation kinetics. A joint application of different techniques was used. The aggregate growth was followed by dynamic light scattering measurements, whereas the conformational changes occurring in the protein structure were monitored by Raman and IR spectroscopy. Both in absence and in presence of metal ions, heating treatment gave rise to b-structures to the detriment of a…

Machine learning classification for COVID19 patients performed on small datasets of CT scans.

2022

In this work we evaluated the possibility of carrying out classifications of the outcome of patients with COVID19 disease through machine learning (ML) techniques working on small datasets of computed tomography (CT) images. In fact, one of the most common problems for medical artificial intelligence (AI) applications is the limited availability of annotated clinical data for model training. In the framework of the artificial intelligence in medicine (AIM) project funded by INFN, we analyzed datasets of CT scans of 79 subjects combined with clinical data containing information relating to positive outcome (no need for intensive care) or poor prognosis (admission into intensive care unit and…

Advances in High-Energy-Resolution CdZnTe Linear Array Pixel Detectors with Fast and Low Noise Readout Electronics

2023

Radiation detectors based on Cadmium Zinc Telluride (CZT) compounds are becoming popular solutions thanks to their high detection efficiency, room temperature operation, and to their reliability in compact detection systems for medical, astrophysical, or industrial applications. However, despite a huge effort to improve the technological process, CZT detectors’ full potential has not been completely exploited when both high spatial and energy resolution are required by the application, especially at low energies (<10 keV), limiting their application in energy-resolved photon counting (ERPC) systems. This gap can also be attributed to the lack of dedicated front-end electronics whic…