Search results for " cultures"

Missense variants in DPYSL5 cause a neurodevelopmental disorder with corpus callosum agenesis and cerebellar abnormalities

2021

International audience; The collapsin response mediator protein (CRMP) family proteins are intracellular mediators of neurotrophic factors regulating neurite structure/spine formation and are essential for dendrite patterning and directional axonal pathfinding during brain developmental processes. Among this family, CRMP5/DPYSL5 plays a significant role in neuronal migration, axonal guidance, dendrite outgrowth, and synapse formation by interacting with microtubules. Here, we report the identification of missense mutations in DPYSL5 in nine individuals with brain malformations, including corpus callosum agenesis and/or posterior fossa abnormalities, associated with variable degrees of intel…

Influence of Laccase and Tyrosinase on the Antioxidant Capacity of Selected Phenolic Compounds on Human Cell Lines

2015

Polyphenolic compounds affect the color, odor and taste of numerous food products of plant origin. In addition to the visual and gustatory properties, they serve as radical scavengers and have antioxidant effects. Polyphenols, especially resveratrol in red wine, have gained increasing scientific and public interest due to their presumptive beneficial impact on human health. Enzymatic oxidation of phenolic compounds takes place under the influence of polyphenol oxidases (PPO), including tyrosinase and laccase. Several studies have demonstrated the radical scavenger effect of plants, food products and individual polyphenols in vitro, but, apart from resveratrol, such impact has not been prove…

Report on the first season of German-Kurdish excavations at Muqable in 2015

2017

In 2015, a new excavation project entitled “Kurdish-German Archaeological Mission in Dohuk” (KUGAMID) was launched. It is organized as a joint project between the University of Tübingen and the Department of Antiquities of Dohuk and is jointly directed by Peter Pfälzner (Tübingen) and Hassan Ahmad Qasim (Dohuk). Three sites were selected for excavation: Bassetki, Muqable I and Muqable III. The following report will summarize the results of the first season of excavations at the two neighbouring mounds of Muqable I and Muqable III, located approximately 5 km southeast of Bassetki and 23 km west of Dohuk in the Autonomous Region of Kurdistan in Iraq. The first season of excavations at Muqable…

Wordarrows: El poder representativo del lenguaje en la obra de no ficción de N. Scott Momaday

2012

This article focuses on two non-fiction works by Native American author N. Scott Momaday: his 1969 historical memoir The Way to Rainy Mountain and his essay collection The Man Made of Words. It specifically tackles performative conceptions of language in the Kiowa storytelling tradition, where words are experienced as speech acts that have the power to intervene in surrounding realities. Taking into account 20th century ethno-cultural and linguistic policies in the United States, the article also reflects on the role indigenous languages may play in contemporary Native American Literature, which has most often been written in English.

Führer durch die Ausstellung zur Erinnerung an den Vaterländischen Krieg von 1812: vom 17. November 1912 bis 6. Januar 1913

1912

Astronomiskās un dabas parādības aizvēsturē Ziemeļeiropā: atspoguļojums vēstures avotos un arheoloģiskajā materiālā

2021

Cilvēka dzīve aizvēsturē bija ļoti cieši saista ar dabu. Līdz ar pāreju uz ražotājsaimniecību vēlā akmens laikmeta beigās, bet īpaši sākot ar bronzas laikmetu, izveidojās ideoloģija, kurā centrālo vietu ieņēma Saule un ar to saistīto gadskārtu cikli. Solārā un lunārā simbolika plaši pārstāvēta Ziemeļeiropas, arī Latvijas arheoloģiskajā materiālā. Dabas un astronomiskās parādības minētas arī pirmajos rakstītajos avotos, bet to sekas – īpaši dabas katastrofu sekas, fiksējamas arī arheoloģiskajā materiālā.

A new culturing strategy optimises Drosophila primary cell cultures for structural and functional analyses

2004

Abstract Neurons in primary cell cultures provide important experimental possibilities complementing or substituting those in the nervous system. However, Drosophila primary cell cultures have unfortunate limitations: they lack either a range of naturally occurring cell types, or of mature physiological properties. Here, we demonstrate a strategy which supports both aspects integrated in one culture: Initial culturing in conventional serum-supplemented Schneider's medium (SM 20K ) guarantees acquisition of all properties known from 30 years of work on cell type-specific differentiation in this medium. Through subsequent shift to newly developed active Schneider's medium (SM active ), neuron…

Designing trehalose-conjugated peptides for the inhibition of Alzheimer’s Aβ oligomerization and neurotoxicity

2008

Campaniformes et cultures locales en France méditerranéenne

2006

Since the 1998 Riva del Garda conference and the synthesis coordinated by J Guilaine (2001), the new bell beakers archaeological data of Mediterranean France make it possible to specify the relations between the Bell Beakers ones and indigenous populations of the final Neolithic in this area. The phase of synchrony between Bell Beakers and local cultures, highlighted for the Early Bell Beakers between 2500 and 2400 before our era, can undoubtedly be wide at the first times, at least, development of the regional groups of recent bell beakers ("Rhodano- Provençal" and "Pyrénéen"). In parallel, differences in relations between these Bell beakers and the indigenous populations can be supposed i…

Territorial and socio-economic organisation in Le Grand-Pressigny

2012

In and around Le Grand-Pressigny (Indre-et-Loire, France), a petrographic study was implementedon 92 ceramic samples from the Final Neolithic sites of Le Petit-Paulmy and Bergeresse (Abilly).Analyses showed that the sediments used were extracted from local sources: Claise and Creusealluvium, local substrate and loessic silts. Quantitatively, the study showed that almost all the ceramicmaterials in Bergeresse and more than half of those in Le Petit-Paulmy come from the valley of theCreuse. The mineralogical compositions of three samples from Le Petit-Paulmy, including one ofunusual form, indicate sources from an exogenous region, the Massif Central (perhaps the alluviumof the Loire or the Al…