Search results for " cyst"
showing 10 items of 432 documents
Valutazione dello stato di conservazione dei popolamenti a Cystoseira nell’AMP Capo Gallo-Isola delle Femmine (PA): osservazioni preliminari
2008
Valutazione dello stato di conservazione dei popolamenti a Cystoseira lungo le coste della Sicilia nord-occidentale: osservazioni preliminari
2006
Human activities trigger change in marine landscape
2018
Biodiversity is undergoing rapid and worrying changes, partially driven by anthropogenic activities. Human impacts and climate change (e.g. increasing temperature and ocean acidification), which act at different spatial scale, represent the most serious threats to biodiversity and ecosystem structure and function. In this overview, the effects of anthropogenic pressures on unique and valuable Mediterranean systems, such as Cystoseira sp. pl. forest and Posidonia oceanica meadows, are examined. These complex systems, characterized by a high associated biodiversity, are regularly exposed to natural and anthropogenic pressures. Due to the central role they have for several important ecological…
Macroalgae transplant to detect the occurrence of anthropogenic nutrients in seawater of highly tourist beaches in Mediterranean islands
2020
In the Mediterranean region, islands are among the most important tourist destinations, being sites of considerable naturalistic, historical and cultural importance. This is highly beneficial for local economies, but may also represent a threat for the environment, especially during the peak season (i.e. summer). Indeed, the sharp demographic increase concentrated in a relatively short period may negatively affect the quality of coastal marine systems and the provision of ecosystem services, producing in turn negative feedbacks on tourism industry. Nevertheless, the assessment of the environmental impact of tourism on coastal seawater has been seldom addressed. Here, we show the results of …
Influence of ambient temperature on the photosynthetic activity and phenolic content of the intertidal Cystoseira compressa along the Italian coastli…
2019
Understanding the physiological responses of intertidal seaweeds to environmental factors is fundamental to characterize their local physiological adaptation and success in the face of climate change. We measured the photosynthetic activity and the total phenolic content of the intertidal alga Cystoseira compressa and explored their relationship with latitude or local ambient air and seawater temperatures. Our results show that, when submerged, the photosynthetic activity of C. compressa showed values typical for non-stressed thalli, and the seawater temperatures found across sites explained the variability of these values. We observed a decrease in the photosynthetic activity of C. compres…
Il Plemmirio e le altre AMP Mediterranee
2011
SEARCH OF MUTATIONS IN CFTR GENE AND IN GENES ENCODING CFTR INTERACTORS IN PATIENTS BEARING ATYPICAL CISTIC FIBROSIS
2011
Hsp27 and Hsp60 in human submandibular salivary gland: Quantitative patterns in healthy and cancerous tissues with potential implications for differe…
2021
Tumors of the submandibular salivary gland (SMG) are uncommon but sufficiently frequent for the physician to consider them in routine examinations and for the pathologist to be prepared to differentiate them from other tissue abnormalities. However, scarcity of specimens makes training difficult, a situation compounded by the lack of accepted universal diagnostic guidelines. Furthermore, there is little information on the chaperone system (CS) of the gland, despite the increasing evidence of its participation in carcinogenesis as a biomarker for diagnosis and patient follow up, and in the mechanisms by which the tumor cells thrive. We are investigating this aspect of various tumors, and her…
PTC124 derivatives as a novel approach to improve the readthrough of premature stop codons in the CFTR gene.
2011
Background Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). Approximately 10% (worldwide) of patients have in-frame nonsense mutations (UAA, UAG or UGA class I mutations) in the CF trans-membrane regulator (CFTR) gene that result in premature stop codons (PTCs) in the messenger RNA (mRNA) generating truncated CFTR protein responsible for a severe CF phenotype. Pharmacological approaches have been proposed to directly overcome PTCs. Ataluren (PTC124) a small molecule that mimics the activity of aminoglycosides has been suggested to allow PTCs readthrough and to partially restore the protein function. However, des…
COMBINING TRANSLATION READTHROUGH INDUCING DRUGS AND NONSENSE MEDIATED DECAY PATWHAY INHIBITION TO THE CFTR RESCUE IN CYSTIC FIBROSIS CELL MODEL SYST…
2021
Nonsense mutations affect 10% of patients with cystic fibrosis and produce a premature termination codon in CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) mRNA causing early termination of translation and leading to lack of CFTR function. A potential therapy for nonsense mutations provides the use of small molecules able to overcome the premature stop codon (PTC) by a readthrough mechanism that lead to synthesis a complete CFTR protein. Despite the good results obtained from this approach, TRIDs efficiency is considerably reduced by the poor amount of target transcript, that is the mRNA containing the PTC. The readthrough, indeed, does not occur on the totality of target transcr…