Search results for " death"
showing 10 items of 1548 documents
[Is ICD-programming for double intraoperative defibrillation threshold energy safe and effective during long-time follow-up? Results of a prospective…
1999
The aim of this prospective and randomized study was to evaluate the safety and efficacy of a reduced shock strength in transvenous implantable defibrillator therapy. So far clinical data concerning the safety margin of the shock energy in ICD therapy do not exist. The shock energy tested during long-term follow-up in this study was twice the intraoperatively measured defibrillation threshold (DFT). A total number of 176 consecutive patients representing a typical cohort of ICD patients were evaluated. All patients received a non-thoracotomy lead system (CPI, Endotak 0070, 0090) and a biphasic cardioverter-defibrillator with the ability to store episodes (Cardiac Pacemakers Inc., Ventac TM …
Stromal Interaction Molecule 1 (STIM1) Is Involved in the Regulation of Mitochondrial Shape and Bioenergetics and Plays a Role in Oxidative Stress
2012
Calcium ions are involved in a plethora of cellular functions including cell death and mitochondrial energy metabolism. Store-operated Ca(2+) entry over the plasma membrane is activated by depletion of intracellular Ca(2+) stores and is mediated by the sensor STIM1 and the channel ORAI1. We compared cell death susceptibility to oxidative stress in STIM1 knock-out and ORAI1 knockdown mouse embryonic fibroblasts and in knock-out cells with reconstituted wild type and dominant active STIM1. We show that STIM1 and ORAI1 deficiency renders cells more susceptible to oxidative stress, which can be rescued by STIM1 and ORAI1 overexpression. STIM1 knock-out mitochondria are tubular, have a higher Ca…
Czas zgonu w kontekście nauk penalnych
2016
Celem pracy jest przybliżenie prawnikom trudu prac, jakie musi wykonać medyk sądowy szacujący czas zgonu. Ma to pomóc w minimalizacji niezrozumienia owej czynności w relacjach przedstawicieli tych dwóch grup zawodowych w procesie karnym. Opis czynności, jakie kolejno następują podczas próby ustalenia interwału pośmiertnego, ma pomóc w zrozumie-niu poziomu komplikacji w stosunku do istniejących regulacji prawnych i możliwości technicz-nych. Innym aspektem jest podkreślenie powagi owych czynności i ich doniosłości w kontekście prawa karnego. W pracy podjęto też próbę zestawienia różnych najważniejszych metod szacowa-nia czasu zgonu – ma to pomóc w ocenie możliwości technicznych, których niezn…
Golgi Fragmentation in Neurodegenerative Diseases: Is There a Common Cause?
2019
In most mammalian cells, the Golgi complex forms a continuous ribbon. In neurodegenerative diseases, the Golgi ribbon of a specific group of neurons is typically broken into isolated elements, a very early event which happens before clinical and other pathological symptoms become evident. It is not known whether this phenomenon is caused by mechanisms associated with cell death or if, conversely, it triggers apoptosis. When the phenomenon was studied in diseases such as Parkinson’s and Alzheimer’s or amyotrophic lateral sclerosis, it was attributed to a variety of causes, including the presence of cytoplasmatic protein aggregates, malfunctioning of intracellular traffic and/or alterations i…
Cell and molecular response to IORT treatment
2014
Ionizing radiations (IRs) generated by intraoperative radiotherapy (IORT) treatment activates both pro- and antiproliferative signal pathways producing an imbalance in cell fate decision regulated by several genes and factors involved in cell cycle progression, survival and/or cell death, DNA repair and inflammation. This paper describes the latest advances on cellular and molecular response to IR, highlighting the most relevant research data from cell biology, gene expression profiling and epigenetic studies on different tumor cell types. Understanding the cell molecular strategies to choose between death and survival, after an irradiation-induced damage, opens new avenues for the selectio…
The Taboo of the Perverse Dying Body
2014
A human being is continuously living towards death within a mortal body that is dying little by little, second after second. In the gloss of popular media, the taboo reality of this stain of mortality is hidden by a diversion, which is created by the multiple pornographies of visual culture: the pornography of perfect bodies and the pornography of violent death. No longer invisible or ‘unspeakable’, the taboo body has been appropriated to serve a function in the mainstream didactics. Both the lusus naturae of natural bodies and the decay of sickness and death are squeezed into such roles in the postmodern visual narrative that the mortality of the human being appears unlikely and accidental…
Association between ideal cardiovascular health and risk of sudden cardiac death and all-cause mortality among middle-aged men in Finland
2021
Background Strong associations have been demonstrated between the American Heart Association’s cardiovascular health (CVH) metrics and various cardiovascular outcomes, but the association with sudden cardiac death (SCD) is uncertain. We examined the associations between these CVH metrics and the risks of SCD and all-cause mortality among men in Finland. Methods and results We used the prospective population-based Kuopio Ischaemic Heart Disease cohort study, which consists of men between 42 and 60 years of age at baseline. CVH metrics were computed for 2577 men with CVH scores at baseline ranging from 0 to 7, categorized into CVH scores of 0–2 (poor), 3–4 (intermediate) and 5–7 (ideal). Mult…
Leisure-Time Physical Activity and All-Cause Mortality : A Systematic Review
2022
Many scientific studies have been shown the positive effect of physical activity (PA) on reducing morbidity and mortality, whereas physical inactivity is globally one of the leading factors in mortality. Therefore, the purpose was to investigate the relationship between leisure-time physical activity (LTPA) and all-cause mortality among adult population. The data search was performed of 3 electronic databases for the years 2000-2021 February as follows: Google Scholar, PubMed, and ResearchGate. This search was made by using the following terms and operators AND/OR, individually/combination: "physical activity", "physical fitness", "leisure-time physical activity", "all-cause mortality", "ri…
Sleep Duration and Risk of Fatal Coronary Heart Disease, Sudden Cardiac Death, Cancer Death, and All-Cause Mortality
2018
Background: Sleep duration has been shown to be associated with all-cause mortality, however its relationship with cause-specific fatal events remains uncertain. We examined the relationship between sleep duration and risk of fatal coronary heart disease (CHD), sudden cardiac death, cancer related death and all-cause mortality. Methods Sleep duration was self-reported at baseline examinations performed between March 20, 1984 and December 5, 1989 in 2,361 men aged 42-61 years old from the Kuopio Ischemic Heart Disease study. Of these 1734 (73.4%) men were free from CHD and cancer at baseline. Results: A total of 802 all cause deaths, 202 fatal coronary heart disease events, 141 sudden cardia…
Fabry Disease, a Complex Pathology Not Easy to Diagnose
2015
Fabry disease is a multisystemic lysosomal storage disorder, inherited in an X-linked manner. It is a defect of metabolism of the glycosphingolipids, due to the reduction or absence of the activity of lysosomal enzyme α-galactosidase A. This reduction of activity causes the storage of globotriaosylceramide and derivatives in the lysosomes, triggering a cascade of cellular events, mainly in vascular endothelium. These events are the responsible for the systemic clinical manifestations and the renal, cardiac and cerebrovascular complications, or a combination of them. The symptomatology can lead to the premature death of patient between the fourth or fifth decade of life. The first symptoms c…