Search results for " development"
showing 10 items of 21333 documents
How Organizational Resources and Managerial Features Affect Business Performance: An Analysis in the Greek Wine Industry
2023
Despite the growing interest of the wine industry in quality and environmental certifications and the influence of these standards on positioning in international markets, scholarly research has paid proportionally limited attention to the link between winery export intensity and the adoption of internationally recognized standards. This study aims to analyze which factors make an organizational model performant, and to verify the impact of the adoption of third-party certifications on the export performance by using the resource-based view (RBV) theory as a theoretical lens. Findings show that younger wineries are more oriented towards the adoption of voluntary quality and environmental ce…
User Involvement and Entrepreneurial Action
2007
Involving users in the innovation process is a subject of much research, experimentation, and debate. Less attention has been given to the limits to user involvement that ensue from specific organizational characteristics. This article explores barriers to the utilization of users’ input in two small companies developing interactive digital applications. We contrast our findings to earlier research involving large companies to identify features of entrepreneurial sensemaking and action that influence the utilization of users’ input. We find that the small companies follow a distinct action rationality, leading to rapid implementation of some user inputs, and defensiveness toward others. Bot…
Towards Measuring the Agility of Software Business
2018
Agile development methods have been employed across the software industry. However, it is not always clear if the used methods actually help the software firms in being more agile and if agility has a positive influence in the software firm performance. Studying these questions may turn out impossible since good measurements for assessing the overall agility of software firms do not yet exist. A need is therefore detected to measure the differences in agility between firms and finding the means to evaluate the differences in agility in reliable manner. This article examines how to measure the agility of a software firm and reports initial steps in the process of developing measurement instr…
A spatial origin‐destination approach for the analysis of local tourism demand in Italy
2023
The article assesses the competitiveness of tourist destinations, while accounting for spatial features of tourism and information on both the origin and the destination of tourists. Using a dynamic spatial panel data model with common factors within the origin-destination framework, it explores unilateral inbound tourism flows in 110 Italian regions from 23 European origin countries over the period 2004-2017. The estimation and test results confirm the need to consider this advanced spatial econometric model. In an empirical application measuring tourism resilience of regions based on this model, the results demonstrate the importance of promoting coordinated actions between neighbouring d…
Misfit evaluation of dental implant-supported metal frameworks manufactured with different techniques: Photoelastic and strain gauge measurements
2016
This study aims to compare in-vitro the fitting accuracy of implant-supported metal frameworks used for full-arch orthodontic restoration. The hypotheses tested were as follows: (1) for a fixed implant morphology, strains developed within the framework depend on how the framework had been fabricated and (2) stresses transferred to the implant–bone interface are related to the amount of framework misfit. Metal frameworks were fabricated using four different manufacturing techniques: conventional lost-wax casting, resin cement luting, electrospark erosion, and computer-aided design/computer-aided manufacturing milling. Each framework was instrumented with three strain gauges to measure strai…
Preparing orphaned/unaccompanied children for sustainable livelihood through "home"-based entrepreneurial education : implications from a care servic…
2019
Entrepreneurship education has been widely discussed in the realm of general education system, but little research has targeted orphaned/unaccompanied children. This research paper explores how entrepreneurship education can be implemented on orphaned/unaccompanied children, and what challenges may occur during the process from educational leaders’ perspective. This research approaches the topic with Sustainable Livelihood Framework. Qualitative case study and semi-structured interview were conducted with a director from a care service provider in northern Thailand. The findings inform us several feasible ways to implement entrepreneurship education on orphaned/unaccompanied children: 1) op…
Assessing violence in the family : social work, courts, and discourses
2016
This article investigates social work, decision-making, and gendered violence in the family in Finland. Discourses on gendered violence in the family are compared in custody disputes, handled in district courts, and out-of-home placements, dealt with in administrative courts. Both data sets altogether include 237 cases. Proceedings in both courts share a legislative emphasis on the ‘child’s best interest’ principle, and both contexts also rely on documentation provided by social workers. The examination of the two studies is based on discourse analysis, through which we have identified hegemonic discourses that are active in both courts. The study found that violence was often disregarded o…
Dynamiques de développement et inégalités régionales en Chine
2009
Le rapide développement économique de la Chine a généré des inégalités socio-spatiales croissantes, qui se marquent par un décalage croissant entre provinces littorales et intérieures, et entre villes et campagnes. À partir de l’examen des données statistiques officielles chinoises, on peut clairement repérer une aggravation des déséquilibres internes de la Chine, qui sont des facteurs potentiels de déstabilisation sociale, en particulier dans le cas des paysans venus tenter leur chance dans les grandes aires urbaines littorales, ou chassés de leurs terres par l’expansion périmétropolitaine. Cela entraîne aujourd’hui une politique différenciée d’aménagement du territoire chinois visant à co…
Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma
2017
Given the paucity of druggable mutations in high-risk neuroblastoma (NB), we undertook chromatin-focused small interfering RNA and chemical screens to uncover epigenetic regulators critical for the differentiation block in high-risk NB. High-content Opera imaging identified 53 genes whose loss of expression led to a decrease in NB cell proliferation and 16 also induced differentiation. From these, the secondary chemical screen identified SETD8, the H4K20me1 methyltransferase, as a druggable NB target. Functional studies revealed that SETD8 ablation rescued the pro-apoptotic and cell-cycle arrest functions of p53 by decreasing p53K382me1, leading to activation of the p53 canonical pathway. I…
Genetic profile and immunohistochemical study of clear cell renal carcinoma: Pathological-anatomical correlation and prognosis.
2021
Abstract Introduction Renal cell carcinoma (RCC) accounts for 2–3% of all tumors being the most frequent solid lesion in the kidney. Objective To determine what genetic alterations and immunohistochemical (IHC) of clear cell renal carcinoma (ccRCC) are associated with prognosis and tumor aggressiveness. Patients and Methods Experimental analytical study with 57 patients who underwent radical and partial nephrectomy between 2005 and 2011, all with diagnosis of ccRCC and minimum post-operative follow-up of 36 months. The pathological study included IHC determination of biomarkers associated (CAIX, CAM 5.2, CD10, c-erbB-2, EGFR, HIF-1a, Ki67, MDM2, PAX-2 y 8, p53, survivin and VEGFR 1 and 2). …