Search results for " development"
showing 10 items of 21333 documents
Discovery of a new class of sortase a transpeptidase inhibitors to tackle gram-positive pathogens: 2-(2-phenylhydrazinylidene)alkanoic acids and rela…
2016
A FRET-based random screening assay was used to generate hit compounds as sortase A inhibitors that allowed us to identify ethyl 3-oxo-2-(2-phenylhydrazinylidene)butanoate as an example of a new class of sortase A inhibitors. Other analogues were generated by changing the ethoxycarbonyl function for a carboxy, cyano or amide group, or introducing substituents in the phenyl ring of the ester and acid derivatives. The most active derivative found was 3-oxo-2-(2-(3,4dichlorophenyl)hydrazinylidene)butanoic acid (2b), showing an IC50 value of 50 µM. For a preliminary assessment of their antivirulence properties the new derivatives were tested for their antibiofilm activity. The most active compo…
Living the urban challenge : sustainable development and social sustainability in two southern megacities
2007
Kehitysmaiden nopea kaupungistuminen ja miljoonakaupunkien voimakas kasvu luovat haasteita kestävään kehitykseen tähtäävälle suunnittelulle. Kansainvälisissä kehitysohjelmissa on pyritty turvaamaan suurkaupunkien taloudelliset ja ympäristölliset tavoitteet. Kestävän kehityksen sosiaalinen ulottuvuus on usein rajattu kaupunkien tarjoamiin sosiaalipalveluihin.- Ympäristön säilyttäminen tuleville sukupolville ei onnistu vain talouteen, ympäristöön ja palveluihin kohdistuvilla teknisillä toimilla. Tämä johtuu etelän suurkaupungeille tyypillisestä räikeästä sosiaalisesta eriarvoisuudesta. Suurkaupunkien suunnittelussa tulisi analysoida sellaisia sosiaalisia haasteita, jotka heikentävät kaupunkie…
Constructing social Europe through European cultural heritage
2021
The political and economic crises of the recent decades as well as the new changes brought on by globalization and digitalization have contributed to exacerbate social inequalities and injustice and revealed different social realities in Europe. The EU increasingly deals with social issues in its cultural and heritage policy. In this article, we explore the construction of this social dimension and advance the concept of 'social Europe' by exploring its cultural aspect based on our analysis of a recent EU heritage action, the European Heritage Label. In this action, the narrations of the European past and the attempts to foster common cultural heritage in Europe function as building blocks …
Nuorten urheilupolut : tutkimus kilpaurheiluun sosiaalistumisen normeista, pääomista ja toimijuudesta
2016
Sport is a popular activity among Finnish children and adolescents. Junior sport encompasses various objectives, and one of its functions is to generate the prerequisites for competitive sport and an elite sports career. This study examines socialization into competitive sport. It approaches the socialization process as a sports path that denotes the sequence of states and events in sport as part of one’s life course. The study emphasizes experiences and through them the meaning-giving and lifeworld of the young athletes themselves. Hence, the aim of the study is to create a sociological interpretation of athlete development. The research data comprise a survey of 2,430 registered participa…
EFL Teacher Education in Finland : Manifestations of Professional Agency in Teacher Educators’ Work
2020
English as a Foreign Language (EFL) teacher educators play a key role in the development of university-based teacher education and the preparation of preservice EFL teachers. However, the professional agency of EFL teacher educators in developing their work remains understudied. Employing a Vygotskian sociocultural theoretical perspective, this research considers the individual and collective professional agency of eight EFL teacher educators at two Finnish universities. Findings demonstrate that individual professional agency is enacted in the expression of professional identity and the development of professional relationships, and in offering and receiving professional assistance. Findin…
Data practices and inequality in South African early childhood development policy: Technocratic management versus social transformation
2019
Background: In 1994, the African National Congress identified early childhood development as a potential strategy to redress the inequalities of apartheid, however, two and a half decades later, poverty still persists, and South Africa is one of the most unequal countries in the world. Aim: This article explores how policy texts based on and with the use of certain data practices establish ‘truths’ about childhoods and society, construct families and communities, and determine forms of provision to address inequality. Setting: In 2015, the South African government published the National Integrated Early Childhood Policy (NIECDP) to continue to address poverty and inequality. Its implementat…
Hierarchies of knowledge, incommensurabilities and silences in South African ECD policy: Whose knowledge counts?
2017
AbstractPolicy for young children in South Africa is now receiving high-level government support through the ANC’s renewed commitment to redress poverty and inequity and creating ‘a better life for all’ as promised before the 1994 election. In this article, I explore the power relations, knowledge hierarchies and discourses of childhood, family and society in National Curriculum Framework (NCF) as it relates to children’s everyday contexts. I throw light on how the curriculum’s discourses relate to the diverse South African settings, child rearing practices and world-views, and how they interact with normative discourses of South African policy and global early childhood frameworks. The NCF…
Web API development and integration for microservice functionality in web applications
2016
Pro gradu -työssä mallinnetaan ja kehitetään mallin mukainen toteutus mikropalvelu-arkkitehtuuriin perustuvasta laajennuksesta olemassaolevaan verkkosovellukseen, joka tutkimuksen mukaan mahdollistaa verkkosovelluksen loppukäyttäjien hyödyntämisen sovelluksen jatkokehittämisessä monoliittisen arkkitehtuurin sovelluksia joustavammin. Pääasiallinen taustateoria sisältää Participative Design ja Design Science -teorioita. This paper presents a model for web application programming interface (API) that uses the microservice architecture to enable and support end-user feature development. The study follows the design-science paradigm of information systems research. Participatory design stands as…
Governance della crisi e importanza del territorio per lo sviluppo regionale
2012
The aim of this paper is a reflection on the role of space in the processes of economic change. Starting in the United States the financial and economic crisis infected Europe after 2007. A wider debate on the current differential role of governments in the U.S. and Europe in addressing the crisis has emerged. The bailout programs in the U.S. have made reference to a unitary and homogeneous reference frame in the presence of a central bank whose broad mandate includes development goals. Europe, instead, has shown a different scenario and the same financial integration project depends on the complex relationship between individuals and the community, national sovereignty and increasingly bin…
The Influence of the Cross-Border Infrastructure Corridor on the Development of Medium-Sized Upper Silesian Cities on the Example of Bohumm and Jastr…
2018
The southern part of the A1 motorway (D1 in Czech designation) is a functioning infrastructure corridor connecting the Czech and Polish parts of the Upper Silesian Agglomeration, which is significant for the development of medium-sized cities in this region. This article is a continuation of research that was conducted in 2013. A research on Czech Bohumin and Polish Jastrzębie Zdrój was repeated with regard to the developmental aspects of these two medium-sized cities in the context of the functioning A1 motorway. The changes that have taken place in recent years in the spatial structure of the mentioned cities have been analysed. Research and analyses were conducted using ArcGIS software o…