Search results for " development"
showing 10 items of 21333 documents
Comparability of a tape-mediated and a face-to-face test of speaking : a triangulation study
1997
Toward modernizing the systematic review pipeline in genetics: efficient updating via data mining
2012
Purpose: The aim of this study was to demonstrate that modern data mining tools can be used as one step in reducing the labor necessary to produce and maintain systematic reviews. Methods: We used four continuously updated, manually curated resources that summarize MEDLINE-indexed articles in entire fields using systematic review methods (PDGene, AlzGene, and SzGene for genetic determinants of Parkinson disease, Alzheimer disease, and schizophrenia, respectively; and the Tufts Cost-Effectiveness Analysis (CEA) Registry for cost-effectiveness analyses). In each data set, we trained a classification model on citations screened up until 2009. We then evaluated the ability of the model to class…
Oppikirja eläköön! : teoreettisia ja käytännön näkökohtia kielten oppimateriaalien uudistamiseen
2009
Matemātikas mācību grāmatas Zahlenbuch 4 iespējas studentu komunikācijas prasmju attīstībā
2022
Globalizācija, cita starpā, ir likusi mūsu pasaulei kļūt arvien nestabilākai un padarīt nākotni grūti prognozējamu. Tādējādi daudzas organizācijas un pētnieki aicina pielāgot izglītību, lai labāk sagatavotu skolēnus nākotnei, attīstot 21. gadsimta prasmes. Viena no svarīgākajām prasmēm, kuras izglītojamie attīsta, ir komunikācijas prasmes. Ņemot vērā, ka prasmes jāattīsta visos mācību priekšmetos, šī pētījuma mērķis ir noskaidrot, cik lielā mērā matemātikas mācību grāmata Zahlenbuch 4 sniedz skolēniem iespējas attīstīt komunikācijas prasmes.
Challenges of Poland's Migration Policy from the Perspective of the Experiences of Selected European Union Countries
2020
Purpose: The purpose of this paper is to discuss the determinants of the development of migration policy in Poland and the activities implemented so far in this field, to analyse the migration policies of selected European Union countries in terms of examining the similarities and differences in migration processes, and finally to indicate the possibility of using their experiences in the system of Polish migration policy that is being created. Design/Methodology/Approach: The main research methods include the desk research method, secondary data analysis as well as publications and expertise prepared in the field of migration policy, while comparative analysis constitutes a complementary r…
Filipinas en el marco del imperio español en el siglo XIX
2019
[EN] En este artículo se analiza la evolución de Filipinas en las últimas décadas del siglo XVIII y en el transcurso del siglo XIX a través de diferentes epígrafes: la obligada transformación del secular modelo colonial volcado hacia el tráfico del Galeón y las relaciones transpacíficas; la renovada inclinación hacia Asia, el océano Índico y el mar de China; el desarrollo de un sistema económico basado en la exportación de productos filipinos y en la apertura de las islas al exterior; la evolución de la vida política; el camino hacia la modernización; el peso de las órdenes religiosas, la importancia de la población china y la colaboración con élites indígenas como rasgos singulares de Fili…
Zrównoważony rozwój w aspekcie zasady jednomyślności i zasady większości w parlamentaryźmie polskim XVI i XVII wieku (1505-1697)
2017
Nie można mówić o zasadach jednomyślności i większości w parlamentaryźmie polskim XVI i XVII wieku, abstrahując od struktury organów przedstawicielskich, ich kompetencji i konkretnych metod podejmowania decyzji. Przedstawione w artykule analizy pozwalają na stwierdzenie, że pomimo tego, że zasada jednomyślności była charakterystyczna dla społeczeństwa stanowego, to już w wieku XVI w praktyce parlamentarnej decydowano w oparciu o zasadę większości. Objawy kryzysu, tj. konfrontacji pomiędzy zasadami, widoczne są już w dwóch ostatnich dziesięcioleciach XVI w. Od połowy wieku XVII prace parlamentu zdominowała zasada jednomyślności, a właściwie jej konsekwencja - liberum veto, decyzja nie zostaj…
On the Choice of the Extracellular Vesicles for Therapeutic Purposes
2019
Extracellular vesicles (EVs) are lipid membrane vesicles released by all human cells and are widely recognized to be involved in many cellular processes, both in physiological and pathological conditions. They are mediators of cell-cell communication, at both paracrine and systemic levels, and therefore they are active players in cell differentiation, tissue homeostasis, and organ remodeling. Due to their ability to serve as a cargo for proteins, lipids, and nucleic acids, which often reflects the cellular source, they should be considered the future of the natural nanodelivery of bio-compounds. To date, natural nanovesicles, such as exosomes, have been shown to represent a source of diseas…
MTOR inhibitor-based combination therapies for pancreatic cancer
2018
Background: Although the mechanistic target of rapamycin (MTOR) kinase, included in the mTORC1 and mTORC2 signalling hubs, has been demonstrated to be active in a significant fraction of patients with pancreatic ductal adenocarcinoma (PDAC), the value of the kinase as a therapeutic target needs further clarification. Methods: We used Mtor floxed mice to analyse the function of the kinase in context of the pancreas at the genetic level. Using a dual-recombinase system, which is based on the flippase-FRT (Flp-FRT) and Cre-loxP recombination technologies, we generated a novel cellular model, allowing the genetic analysis of MTOR functions in tumour maintenance. Cross-species validation and pha…
Exergoeconomics as a Cost-Accounting Method in Thermal Grids with the Presence of Renewable Energy Producers
2022
Thermal grids are efficient, reliable, and sustainable technologies for satisfying the thermal demands of buildings. The capability to operate at a low temperature allows not only for the integration of heat produced by renewable energy sources but also for the storage of surplus electricity from the grid via “power to heat” technologies. Besides, in the future, heat consumers are expected to behave increasingly as “prosumers”, supplying in some periods heat produced by renewable energy plants on site. In this scenario, it is important to propose a method for the cost allocation among producers connected to the grid. In this regard, this paper proposes Exergoeconomic…