Search results for " development"

Protein tyrosine nitration and thiol oxidation by peroxynitrite-strategies to prevent these oxidative modifications.

2013

The reaction product of nitric oxide and superoxide, peroxynitrite, is a potent biological oxidant. The most important oxidative protein modifications described for peroxynitrite are cysteine-thiol oxidation and tyrosine nitration. We have previously demonstrated that intrinsic heme-thiolate (P450)-dependent enzymatic catalysis increases the nitration of tyrosine 430 in prostacyclin synthase and results in loss of activity which contributes to endothelial dysfunction. We here report the sensitive peroxynitrite-dependent nitration of an over-expressed and partially purified human prostacyclin synthase (3.3 μM) with an EC50 value of 5 μM. Microsomal thiols in these preparations effectively co…

The new face of university–business cooperation in Finland

2016

This paper analyses the development of university-business cooperation (UBC) in Finland in the context of the University Reform Act of 2009, drawing on the experience of four universities: Aalto University, University of Jyvaskyla, University of Turku, and Lappeenranta University of Technology. Six UBC dimensions are examined: institutional context, stakeholders, motivations, facilitators/inhibitors, benefits, and drawbacks. We find that UBC, while a relatively recent process, is growing fast in dynamic local innovation and entrepreneurship ecosystems. The University Act of 2009 had an uneven effect on the six UBC dimensions, with the most visible impact being manifested on motivations. Aal…

Editorial: Thymic Epithelial Cells: New Insights Into the Essential Driving Force of T-Cell Differentiation.

2021

Information, Communications and Media Technologies for Sustainability: Constructing Data-Driven Policy Narratives

2021

This paper introduces the idea of data-driven narratives to examine how the use of information, communications, and media technologies (ICMTs) impacts the sustainable growth of economies. While ICMTs have regularly been advocated as a policy tool for growth and development, there is a research gap in empirical studies validating how such policies may be effective. This analysis is based on historical panel data from 39 economies across the developed North (19) and developing South (20). The industry-standard Cross-Industry Standard Process for Data Mining (CRISP-DM) methodology was applied to construct narratives that weave extant theories with empirical data. The art of developing data-dri…

Organisational GDPR Investments and Impacts

2023

The aim of this empirical multi-case study is to understand the GDPR investments and impacts of the organisations. Among these, the measuring experiences related to GDPR and information security (Isec), and the future expectations are examined. Several interesting findings were recognised, which also enabled further suggestions. First, an understanding of the organisations’ investments and their impact is built by gathering information about the actions that organisations made to fulfil the GDPR requirements. In the second phase, it is deemed necessary to examine how organisations experience the measures and evaluation of GDPR development and progress, in order to understand how respondents…

High-rise timber architecture: an opportunity for the sustainability of the built environment

2019

Bioeconomy, circular economy, land use reduction, sustainable use of natural resources, reduction of CO2 emissions in the atmosphere and recycling are the keywords which the building world must face in the near future, as the environmental emergency can no longer be postponed. In order to disseminate in the scientific community the different possibilities of timber as a sustainable building material throughout its whole life cycle and to provide the professionals with suitable decision-making tools for a conscious design, within the cultural and scientific scenario of the recent years, the paper serves as a moment of reflection highlighting how a closer integration between different sectors…

Qualitative analysis of housing demand using Google trends data

2019

Big data analytics often refer to the breakdown of huge amounts of data into a more readable and useful format. This study utilises Google Trends big data as a proxy for an analysis of housing demand. We employ a qualitative method (fuzzy set/Qualitative Comparative Analysis, fsQCA), instead of a quantitative method, for our estimate and forecast. The empirical results show that fsQCA successfully forecasts seasonal time series, even though the dataset is small in size. Our findings fill the gap in the qualitative and time series forecasting literature, and the forecasting procedure herein also offers a good standard for industry.

Single-cell analysis of population context advances RNAi screening at multiple levels

2012

Isogenic cells in culture show strong variability, which arises from dynamic adaptations to the microenvironment of individual cells. Here we study the influence of the cell population context, which determines a single cell's microenvironment, in image‐based RNAi screens. We developed a comprehensive computational approach that employs Bayesian and multivariate methods at the single‐cell level. We applied these methods to 45 RNA interference screens of various sizes, including 7 druggable genome and 2 genome‐wide screens, analysing 17 different mammalian virus infections and four related cell physiological processes. Analysing cell‐based screens at this depth reveals widespread RNAi‐induce…

Self-regulatory efficacy and sources of efficacy in elementary school pupils: Self-regulatory experiences in a population sample and pupils with atte…

2019

In this study, we examined self-regulatory efficacy and sources of self-efficacy (mastery experiences, vicarious experiences, social persuasion and physiological/emotional states) and the relationships between self-efficacy and its sources among elementary school pupils. Two groups were compared: a population sample (PS, N = 1284) and pupils with difficulties in attention and executive functions (AED, N = 61). Data gathered from self-report questionnaires indicated that pupils in the PS group had more positive efficacy beliefs and mastery experiences and fewer negative physiological/emotional states than the AED group. Analyses showed strong connections between sources and self-regulatory e…

Response-To-Intervention in Finland and the United States: Mathematics Learning Support as an Example

2018

Response to Intervention (RTI) was accepted in the early 2000s as a new framework for identifying learning difficulties (LD) in the U.S. In Finland, a similar multi-tiered framework has existed since 2010. In the present study, these frameworks are presented from the viewpoint of the role of assessment and instruction as expressed in documents that describe the frameworks, as it seems that these two components of RTI are the most disparate between the U.S. and Finland. We present a suggestion for the Finnish framework as an example of support in mathematics learning that incorporates principles of RTI (such as systematized assessment and instruction, cyclic support, and modifiable instructi…