Search results for " dose"

Study of CT/MRI mutual information based registration applied in brachytherapy

2016

The present work aims to include magnetic resonance imaging (MRI) in a Medical Image-based Graphical platfOrm - Brachytherapy module (AMIGOBrachy) which coupled to the Monte Carlo N-Particle (MCNP6) code allows absorbed dose calculations. Computed tomography (CT) and MRI images were registered using mutual information algorithms to improve tissue segmentation potentially leading to a more accurate treatment planning system.

Effects of different doses of doxepin on passive avoidance learning in rats

2013

Background: Studies have shown that Doxepin has anti-inflammatory effects and reduces oxidative stress. Due to the fact that other tricyclic antidepressants have been shown to have neuroprotective effects, this study aimed to investigate the effects of different doses of doxepin on passive avoidance learning in rats. Materials and Methods: Old male Wistar rats were used in this study. Doxepin was administered intraperitoneally (1, 5 and 10 mg/kg) for 21 days. Passive avoidance learning test was used for evaluation of learning and memory. Rats received foot electrical shock on fifteen day, and step through latencies were evaluated one week after the electrical shock in retention phase. Resul…

Multigenerational study of the obesogen effects of bisphenol S after a perinatal exposure in C57BL6/J mice fed a high fat diet.

2021

International audience; Background : Bisphenol S is an endocrine disruptor exhibiting metabolic disturbances, especially following perinatal exposures. To date, no data are available on the obesogen effects of BPS in a mutligenerational issue.Objectives : We investigated obesogen effects of BPS in a multigenerational study by focusing on body weight, adipose tissue and plasma parameters in male and female mice.Methods : Pregnant C57BL6/J mice were exposed to BPS (1.5 μg/kg bw/day ie a human equivalent dose of 0.12 μg/kg bw/day) by drinking water from gestational day 0 to post natal day 21. All offsprings were fed with a high fat diet during 15 weeks. Body weight was monitored weekly and fat…

The Impact of Prescribed Dosage Assumptions on the Evaluation of Adherence and Persistence to Medication in Patients After Acute Myocardial Infarction

2021

Medication adherence is a significant problem in public health. Prescription-level pharmacy databases have great potential for monitoring actual drug adherence patterns at the healthcare system level. Many research papers have reported adherence estimates in different settings and populations. However, comparison between studies is not always straightforward due to different approaches taken when computing adherence. A crucial component to accurately estimate adherence is the availability of days’ supply information for each dispensing event. Reasonable assumptions regarding medication dosage have to be made, when this information is not available. In this study, we evaluate adherence and p…

IVIG in APS pregnancy

2004

For more than two decades, the intravenous administration of high doses of IgG pooled from the plasma of healthy donors (immune globulin therapy, also known as ‘IVIG’) has benefited patients with a variety of autoimmune disorders. A potential therapeutic role of IVIG in the prevention of thrombosis and of miscarriages in antiphospholipid syndrome (APS) has been postulated. Multicenter randomized controlled trials attempted to define the role of IVIG in preventing pregnancy complications in APS indicate that simple anticoagulation could not be completely satisfactory, and certain patient subgroups might take advantage of IVIG therapy alone or in combination with heparin.

Therapeutic effects of different doses of botulinum toxin in chronic anal fissure

1999

PURPOSE: The aim of this study was to evaluate the clinical and manometric results of three different doses of botulinum toxin and two methods of injection for the treatment of chronic idiopathic anal fissure. METHODS: Sixty-nine patients with chronic anal fissure were included in a nonrandomized, prospective trial of intrasphincteric injection of botulinum toxin. All patients reported postdefecatory anal pain lasting more than two months. Scoring systems were developed for anal pain, bleeding, and defecatory difficulty. Maximum resting and squeeze anal pressures were determined before and one month after treatment. Twenty-three patients undergoing a 5-U injection of diluted botulinum toxin…

319: Single shot spinal anaesthesia with low dose hyperbaric bupivacaine (3.75 mg), for hip fracture repair surgery in the elderly

2007

The effect of two sulphur-containing pesticides, fenitrothion and endosulfan, on glutathione (GSH) content and on GSH S-transferase and gamma-glutamy…

1988

The glutathione (GSH) system of Procambarus clarkii (P.c.), the American red crayfish, is used as a marker of the effects of Fenitrothion (FT) and Endosulfan (ES), organophosphorus and organochlorinated insecticides, respectively. This system has been shown to be sensitive to different heavy metals poisoning, thus it has a double interest as marker for environmental contamination and as a potential source of xenobiotics or their metabolites to humans, since it is being fished commercially. The GSH content of the organ decreased 24 h after treatment with FT. FT promotes a 2-fold induction of GSH S-transferase (GST) activity at 6 h which is followed by a decrease of it at 24 h. The latter coi…

Successful treatment of axillary hyperhidrosis with very low doses of botulinum toxin B: a pilot study

2003

Impact of the Tiloop Bra mesh in CT images and dose delivery in breast radiotherapy

2012

A new titanized breast mesh, TiLOOP Bra, is currently available for implantation in patients who require radiotherapy. The purpose of this work is to study the dosimetric effect of the presence of a TiLOOP Bra mesh on breast radiation treatment and radiographic imaging. The dosimetric effects have been measured for three X‐ray energies: 1.25 MeV, 6 MV and 18 MV, using radiochromic films placed at three different depths. These depths are representative of mesh location in breast during the radiotherapy treatment and hence, are of interest in this study. In order to assess the disturbance in a radiographic image, different computed tomographic (CT) studies of the mesh have been performed. The…