Search results for " drug delivery system"
showing 10 items of 39 documents
PEGYLATED PHOSPHOLIPID-POLYASPARTAMIDE COPOLYMERS AS SELF-ASSEMBLING COLLOIDAL DRUG DELIVERY SYSTEMS
2009
ANTICANCER RELEASING FILMS AND POROUS SCAFFOLDS BASED ON PHYSICALLY ASSEMBLED HYALURONIC ACID DERIVATIVES
2012
Preparation of drug-polymer composites by polymerization in supercritical carbon dioxide: a new method to increase the dissolution rate of bioactive …
2008
THERAPEUTIC-LOADED LIPID NANOSTRUCTURES AND BRAIN DISEASES.
2012
Central Nervous System (CNS) diseases represent the largest and fastest growing area of unmet medical need since an alarming increase in brain disease incidence is going on. Despite major advances in neuroscience, many potential therapeutic agents are denied access to the CNS because of the existence of a physiological low permeable barrier, the Blood-Brain Barrier (BBB). To obtain an improvement of drug CNS performance, sophisticated approaches such as nanoparticulate systems are rapidly developing. In particular, in this chapter, the most recent data demonstrating the potential of lipid nanostructures, such as Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC), to tra…
Synthetic/ECM-inspired hybrid platform for hollow microcarriers with ROS-triggered nanoporation hallmarks
2017
Reactive oxygen species (ROS) are key pathological signals expressed in inflammatory diseases such as cancer, ischemic conditions and atherosclerosis. An ideal drug delivery system should not only be responsive to these signals but also should not elicit an unfavourable host response. This study presents an innovative platform for drug delivery where a natural/synthetic composite system composed of collagen type I and a synthesized polythioether, ensures a dual stimuli-responsive behaviour. Collagen type I is an extracellular matrix constituent protein, responsive to matrix metalloproteinases (MMP) cleavage per se. Polythioethers are stable synthetic polymers characterized by the presence o…
BINDING INTERACTIONS OF SMALL MOLECULES TO SURFACE OF CARBON NANOHORNS AS A ROUTE TO DRUG DELIVERY
2014
"Click" on PLGA-PEG and hyaluronic acid: gaining access to anti-leishmanial pentamidine bioconjugates
2018
Pentamidine (Pent), an antiparasitic drug used for the treatment of visceral leishmaniasis, has been modified with terminal azide groups and conjugated to two different polymer backbones (PLGA-PEG [PP] copolymer and hyaluronic acid [HA]) armed with alkyne end-groups. The conjugation has been performed by Copper Catalyzed Azido Alkyne Cycloaddition (CuAAC) using CuSO4/sodium ascorbate as metal source. The novel PP-Pent and HA-Pent bioconjugates are proposed, respectively, as non-targeted and targeted drug delivery systems against Leishmania infections. Moreover, Pent has been encapsulated into PP nanoparticles by the oil-in-water emulsion method, with the aim to compare the biological activi…
Inulin Coated Gold Nanoparticles As a Potential Tool For Cancer Therapy
2014
Covalently modified halloysite clay nanotubes: synthesis, properties, biological and medical applications
2017
Halloysite (HNT) is a promising natural nanosized tubular clay mineral that has many important uses in different industrial fields. It is naturally occurring, biocompatible, and available in thousands of tons at low cost. As a consequence of a hollow cavity, HNT is mainly used as nanocontainer for the controlled release of several chemicals. Chemical modification of both surfaces (inner lumen and outer surface) is a strategy to tune the nanotube's properties. Specifically, chemical modification of HNT surfaces generates a nanoarchitecture with targeted affinity through outer surface functionalization and drug transport ability from functionalization of the nanotube lumen. The primary focus …