Search results for " effective"
showing 10 items of 380 documents
Economic evaluations of ergonomic interventions preventing work-related musculoskeletal disorders: a systematic review of organizational-level interv…
2017
Background Work-related musculoskeletal disorders (WMSD) represent a major public health problem and economic burden to employers, workers and health insurance systems. This systematic review had two objectives: (1) to analyze the cost-benefit results of organizational-level ergonomic workplace-based interventions aimed at preventing WMSD, (2) to explore factors related to the implementation process of these interventions (obstacles and facilitating factors) in order to identify whether economic results may be due to a successful or unsuccessful implementation. Methods Systematic review. Studies were searched in eight electronic databases and in reference lists of included studies. Companio…
Theory-based digital intervention to promote weight loss and weight loss maintenance (Choosing Health)
2020
IntroductionDigital behavioural weight loss interventions have the potential to improve public health; however, these interventions are often not adequately tailored to the needs of the participants. This is the protocol for a trial that aims to determine the effectiveness and cost-effectiveness of the Choosing Health programme as a means to promote weight loss and weight loss maintenance among overweight/obese adults.Methods and analysisThe proposed study is a two-group randomised controlled trial with a nested interrupted time series (ITS) within-person design. Participants (n=285) will be randomly assigned to either the Choosing Health digital intervention or a control group. For interve…
Viaggi nell’immaginario: il turismo virtuale nel sito UNESCO di Tarragona
2023
Le nuove tecnologie hanno trasformato in modo radicale non solo la geografia come disciplina, ma anche le geografie del mondo. Il digitale ha assunto, infatti, un ruolo di mediazione sempre più pervasivo nella produzione dello spazio, come delle conoscenze e degli immaginari geografici. Le possibilità offerte dal virtuale, in particolare, offrono oggi un contributo decisivo nella comunicazione dei significati attribuiti ai luoghi e rispondono in modo sempre più efficace ai bisogni emergenti del settore turistico. Le esperienze di visita mediate dal digitale mirano a coinvolgere i sensi e risultano efficaci quando promuovono immersioni rigorosamente realistiche. Nel quadro di queste riflessi…
The NA48 event-building PC farm
2003
The NA48 experiment at the CERN SPS aims to measure the parameter $\Re(\epsilon'/ \epsilon)$ of direct CP violation in the neutral kaon system with an accuracy of $2 \times 10^{-4}$. Based on the requirements of: \\\\ * high event rates (up to 10 kHz) with negligible dead time;\\ * support for a variety of detectors with very wide variation in the number of readout channels;\\ * data rates of up to 150 MByte/s sustained over the beam burst;\\ * level-3 filtering and remote data logging in the CERN computer center; \\\\ the collaboration has designed and built a modular pipelined data flow system with 40 MHz sampling rate. The architecture combines custom-designed components with commerciall…
Simulating core excitation in breakup reactions of halo nuclei using an effective three-body force
2022
We extend our previous calculation of the breakup of 11Be using Halo Effective Field Theory and the Dynamical Eikonal Approximation to include an effective 10Be-n-target force. The force is constructed to account for the virtual excitation of 10Be to its low-lying 2+ excited state. In the case of breakup on a 12C target this improves the description of the neutron-energy and angular spectra, especially in the vicinity of the 11Be 5/2+ state. By fine-tuning the range parameters of the three-body force, a reasonable description of data in the region of the 3/2+ 11Be state can also be obtained. This sensitivity to the three-body force's range results from the structure of the overlap integral …
Effective field theory after a new-physics discovery
2018
When a new heavy particle is discovered at the LHC or at a future high-energy collider, it will be interesting to study its decays into Standard Model particles using an effective field-theory framework. We point out that the proper effective theory can not be constructed as an expansion in local, higher-dimensional operators; rather, it must be based on non-local operators defined in soft-collinear effective theory (SCET). For the interesting case where the new resonance is a gauge-singlet spin-0 boson, which is the first member of a new sector governed by a mass scale $M$, we show how a consistent scale separation between $M$ and the electroweak scale $v$ is achieved up to next-to-next-to…
Branching fraction measurements of the color-suppressed decaysB¯0toD(*)0π0,D(*)0η,D(*)0ω, andD(*)0η′and measurement of the polarization in the decayB…
2011
We report updated branching fraction measurements of the color-suppressed decays B ^(0) → D^(0)π^(0), D^(*0)π^(0), D^(0)η, D^(*0)η, D^(0)ω, D^(*0)ω, D^(0)η′, and D^(*0)η′. We measure the branching fractions (×10^(-4)): B(B^0 → D^(0)π^(0)) = 2.69±0.09±0.13, B(B^(0) → D^(*0)π^(0)) = 3.05±0.14±0.28, B(B^(0) → D^(0)η) = 2.53±0.09±0.11, B(B^(0) → D^(*0)η) = 2.69±0.14±0.23, B(B^(0) → D^(0)ω) = 2.57±0.11±0.14, B(B^(0) → D^(*0)ω) = 4.55±0.24±0.39, B(B^(0)→D^(0)η′) = 1.48±0.13±0.07, and B(B^(0) → D^(*0)n′) = 1.49±0.22±0.15. We also present the first measurement of the longitudinal polarization fraction of the decay channel D*0ω, fL=(66.5±4.7±1.5)%. In the above, the first uncertainty is statistical …
Distribution of human papillomavirus types in women from Valencia, Spain, with abnormal cytology.
2010
Objective To determine human papillomavirus (HPV) types among cervical smears using polymerase chain reaction (PCR) and to contribute to the knowledge of human papillomavirus genotype distribution and prevalence of oncogenic types in cervical lesions in Spain. Study Design Consensus PCR and direct sequencing of PCR products (DNA HPV typing) were used in a retrospective study to determinate the type or types of HPV on 974 cytology smears of women with abnormal cytology results. Results Of 974 smears, 79.8% were high-risk (H-R) HPVs, 19.7% low-risk (L-R) HPVs, 4.6% indeterminate-risk (I-R) HPVs, considering both single and multiple infections. Multiple infections were detected in 4.7% of the …
Bortezomib induction, reduced-intensity transplantation, and lenalidomide consolidation-maintenance for myeloma: updated results.
2013
A sequential approach including bortezomib induction, intermediate-dose melphalan, and autologous stem cell transplantation (ASCT), followed by lenalidomide consolidation-maintenance, has been evaluated. Efficacy and safety data have been analyzed on intention-to-treat and results updated. Newly diagnosed myeloma patients 65 to 75 years of age (n = 102) received 4 cycles of bortezomib-pegylated liposomal doxorubicin-dexamethasone, tandem melphalan (100 mg/m(2)) followed by ASCT (MEL100-ASCT), 4 cycles of lenalidomide-prednisone consolidation (LP), and lenalidomide maintenance (L) until disease progression. The complete response (CR) rate was 33% after MEL100-ASCT, 48% after LP and 53% after…
Pharmacogenomics of cetuximab in metastatic colorectal carcinoma
2014
Cetuximab is a chimeric monoclonal antibody that has revolutionized the treatment of metastatic colorectal cancer. Knowledge of the mechanisms that underlie its effectiveness, as well as the primary and secondary resistance mechanisms, have led to important developments in the understanding of cetuximab biology. In light of knowledge gained from recent trials, the efficacy of cetuximab has been clearly demonstrated to depend upon RAS mutational status, moreover cetuximab should only be used in a subset of patients who may benefit. In this article, we critically review clinical and pharmacogenetic issues of cetuximab, focusing on the cost–effectiveness involved with the use of the drug.