Search results for " efficacy"
showing 10 items of 282 documents
Country-specific differences of age stereotypes towards older hospital staff and their association with self-efficacy, work ability and mental well-b…
2020
To compare stereotypes towards older workers between hospital staff in Germany and Latvia and to analyse the relationship between those stereotypes and self-efficacy, subjective work ability and irritation.Cross-sectional study.In 2018, hospital staff, including nurses, physicians and other professions, of two German and three Latvian hospitals were asked to complete the standardized study questionnaire on subjective work ability, occupational self-efficacy, irritation and stereotypes towards older workers. In the latter scale older workers were defined as ≥45 years of age and the scale ranged from 27-135 whereby higher values reflect higher levels of positive stereotypes. To analyse the re…
Articaine versus lidocaine inferior alveolar nerve block in posterior mandible implant surgeries: a randomized controlled trial
2023
Background: The aim of this study is to compare the effects of %4 articaine and %2 lidocaine on inferior alveolar nerve block (IANB) for implant surgery in the posterior mandible.Material and Methods: The patients who have inserted implants in the posterior mandible were divided into 2 groups for IANB: lidocaine and articaine. VAS = visual analog scale, pain during surgery and injection, lip numb-ness time, mandibular canal-implant apex distance, age, gender, bone density, implant number, release incision, adjacent teeth, and duration of surgery were analyzed using t-test, Mann-Whitney U test, Spearman's coefficient, and, Pearson's chi-squared test. This trial followed the recommendations o…
Highly purified chondroitin sulfate: a literature review on clinical efficacy and pharmacoeconomic aspects in osteoarthritis treatment
2020
AbstractOsteoarthritis (OA) is the most prevalent musculoskeletal disease and a major cause of negative relevant outcomes, associated with an ever-increasing societal burden. Pharmaceutical-grade chondroitin sulfate (CS) was repeatedly reported to reduce pain and improve function in patients with OA. This article aims to review the evidence for the role of highly purified (hp) CS (Condrosulf®, IBSA) in the treatment of OA. We collected and reported evidence concerning (1) efficacy of hpCS 800 mg/day in the treatment of OA affecting the knee, hand and hip; (2) efficacy and safety of hpCS 1200 mg/day also in the oral gel formulation; (3) the safety profile of hpCS; (4) the difference of hpCS …
The zebrafish embryo as an in vivo model for screening nanoparticle-formulated lipophilic anti-tuberculosis compounds.
2021
ABSTRACT With the increasing emergence of drug-resistant Mycobacterium tuberculosis strains, new and effective antibiotics against tuberculosis (TB) are urgently needed. However, the high frequency of poorly water-soluble compounds among hits in high-throughput drug screening campaigns is a major obstacle in drug discovery. Moreover, in vivo testing using conventional animal TB models, such as mice, is time consuming and costly, and represents a major bottleneck in lead compound discovery and development. Here, we report the use of the zebrafish embryo TB model for evaluating the in vivo toxicity and efficacy of five poorly water-soluble nitronaphthofuran derivatives, which were recently id…
Repensando la educación. Trayectoria y futuro de los sistemas educativos modernos
2019
Este artículo tiene por objetivo reflexionar sobre la doble condición de las reformas educativas requeridas en las sociedades avanzadas: como elemento de conocimiento político-sociológico y como acción reguladora social. A nivel metodológico se plantea una hermenéutica de las principales representaciones del cambio educativo, y se subraya que las reformas no deben subordinarse sólo a las necesidades sociológicas del momento. En esta línea, se exponen las demandas de cambio acaecidas a partir de PISA, así como las críticas que este modelo de evaluación ha recibido. Los principales resultados de los estudios internacionales analizados indican que comparar sistemas educativos y alumnado a part…
What’s in a name : the effect of category labels on teachers’ beliefs.
2019
In this paper, we report an investigation of the possible influence on teachers’ essentialist thinking and efficacy beliefs of category labels used to describe children’s educational difficulties. A 2x2x2 counterbalanced design was employed in which primary school teachers in Finland and the UK were exposed to vignettes that portrayed a child exhibiting difficulties in one of two domains: either behaviour or reading. Vignettes were presented in two versions. In one, the child was labelled as having either ‘ADHD’ or ‘Dyslexia’; in the alternate condition, no such label was ascribed, descriptions were identical in all other respects. Participating teachers were presented with two vignettes, o…
An Examination of the Structure of the Career Decision Self-Efficacy Scale (Short Form) Among Italian High School Students
2013
This study aims to evaluate the factor structure of Career Decision Self-Efficacy scale-short form in a sample of Italian high school adolescents. confirmatory factor analysis (CFA) was used to test the degree to which a one-factor structure and a five-factor structure provided the best fit. In view of available research the five-factor structure was expected to provide the best fit. Moreover, factorial invariance in males and females was tested. It was expected to be invariant across groups. As expected the five-factor structure showed a better fit than the one-factor model and the factorial invariance resulted invariant across boys and girls.
Foxp3 Silencing with Antisense Oligonucleotide Improves Immunogenicity of an Adjuvanted Recombinant Vaccine against Sporothrix schenckii
2021
Made available in DSpace on 2021-06-25T10:56:14Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-04-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Background: In recent years, there has been great interest in developing molecular adjuvants based on antisense oligonucleotides (ASOs) targeting immunosuppressor pathways with inhibitory effects on regulatory T cells (Tregs) to improve immunogenicity and vaccine efficacy. We aim to evaluate the immunostimulating effect of 2′OMe phosphorothioated Foxp3-targeted ASO in an antifungal adjuvanted recombinant vaccine. Methods: The uptake kinetics of Foxp3 ASO, its cyto-toxicity and its ability to deplete Tregs were evaluated in…
Determining the efficiency of optical sources using a smartphone's ambient light sensor
2017
This work reports the use of a smartphone’s ambient light sensor as a valuable tool to study and characterize the efficiency of an optical source. Here, we have measured both luminous efficacy and efficiency of several optical sources (incandescent bulb and halogen lamp) as a function of the electric power consumed and the distance to the optical detector. The illuminance of LEDs as a function of the distance to the optical detector is characterized for different wavelength emissions. Analysis of the results confirms an inverse-square law of the illuminance with the detector–source distance and shows good agreement with values obtained by classical experiments. This experience will trigger …
Biomedical implications of viral mutation and evolution
2012
Mutation rates vary hugely across viruses and strongly determine their evolution. In addition, viral mutation and evolution are biomedically relevant because they can determine pathogenesis, vaccine efficacy and antiviral resistance. We review experimental methods for estimating viral mutation rates and how these estimates vary across viral groups, paying special attention to the more general trends. Recent advances positing a direct association between viral mutation rates and virulence, or the use of high-fidelity variants as attenuated vaccines, are also discussed. Finally, we review the implications of viral mutation and evolution for the design of rational antiviral therapies and for e…