Search results for " efficacy"
showing 10 items of 282 documents
Efficacy of Long-Term Treatment of Autosomal Recessive Hypercholesterolemia With Lomitapide: A Subanalysis of the Pan-European Lomitapide Study
2022
Backgroundand aim: Autosomal recessive hypercholesterolemia (ARH) is a rare autosomal recessive disorder of low-density lipoprotein (LDL) metabolism caused by pathogenic variants in the LDLRAP1 gene. Like homozygous familial hypercholesterolemia, ARH is resistant to conventional LDL-lowering medications and causes a high risk of atherosclerotic cardiovascular diseases (ASCVDs) and aortic valve stenosis. Lomitapide is emerging as an efficacious therapy in classical HoFH, but few data are available for ARH.Results: This is a subanalysis carried out on nine ARH patients included in the Pan-European Lomitapide Study. The age at starting lomitapide was 46 (interquartile range (IQR), 39.0–65.5) y…
Systematic review and exploratory meta-analysis of the efficacy, safety, and biological effects of psychostimulants and atomoxetine in patients with …
2019
ObjectiveOur aim was to summarize the efficacy and safety of atomoxetine, amphetamines, and methylphenidate in schizophrenia.MethodsWe undertook a systematic review, searching PubMed/Scopus/Clinicaltrials.gov for double-blind, randomized, placebo-controlled studies of psychostimulants or atomoxetine in schizophrenia published up to 1 January 2017. A meta-analysis of outcomes reported in two or more studies is presented.ResultsWe included 22 studies investigating therapeutic effects of stimulants (k=14) or measuring symptomatic worsening/relapse prediction after stimulant challenge (k=6). Six studies of these two groups plus one additional study investigated biological effects of psychostimu…
Comparable efficacy and safety of dimethyl fumarate and teriflunomide treatment in Relapsing-Remitting Multiple Sclerosis: an Italian real-word multi…
2018
BACKGROUND: The aim of the study was to evaluate the achievement of 'no evidence of disease activity' (NEDA) over a 12-month period in a large multicenter population with relapsing remitting multiple sclerosis (RRMS) treated with delayed-release dimethyl fumarate (DMF) and teriflunomide (TRF) using a propensity-score adjustment. METHODS: A time-to-event method was used to determine the percentages of patients with RRMS (pwRRMS) in both groups achieving NEDA 3 (no relapses, no 12-week confirmed disability progression, and no new T2/gadolinium-enhancing brain lesions). We described the safety profile of the investigated drugs. RESULTS: Of the 587 pwRRMS treated with DMF and the 316 pwRRMS tre…
Systematic review and meta-analysis of the efficacy and safety of minocycline in schizophrenia
2017
ObjectiveOur aim was to perform an updated systematic review and meta-analysis on the efficacy and safety of adjunctive minocycline as a treatment of schizophrenia.MethodsWe conducted a PubMed/Scopus database search from inception to 3 February 2016 for randomized, placebo-controlled trials (RCTs), open non-randomized studies, and case reports/series evaluating minocycline in patients with schizophrenia. Random-effects meta-analysis of positive, negative, depressive, and cognitive symptom rating scales, discontinuation and adverse effects rates calculating standardized mean difference (SMD), and risk ratios±95% confidence intervals (CI95%) were calculated.ResultsSix RCTs were eligible (mino…
Sydänkuntoutujien näkemyksiä minäpystyvyydestä
2018
Minäpystyvyys on Albert Banduran kehittämä käsite, joka on osa sosio-kognitiivista teoriaa. Tämä pro gradu -tutkielma tutkielma on osa Jyväskylän yliopiston, Kelan sekä Kuntoutus Peurungan yhteistä tutkimushanketta (2015-2019). Tässä tutkimuksessa on tarkoitus selvittää, millaisia näkemyksiä sydänkuntoutujilla on minäpystyvyydestä etäkuntoutuksen alussa. Tutkimuksen aineistona oli seitsemän ryhmähaastattelua, tutkittavina oli yhteensä 65 sydänkuntoutujaa. Aineistona oli 396 min haastattelua, joista kertyi 283 A4 sivua litteroitua tekstiä. Aineisto analysoitiin laadullisin menetelmin sisällönanalyysillä. Apuna aineiston luokittelussa käytettiin ATLAS.ti sisällönanalyysiohjelmaa. Sisällönanal…
Self-regulatory Efficacy and Foreign Language Attainment
2016
The foreign language learning process is lengthy and full of obstacles, while the most significant learning effects are quite delayed in time, and difficult to notice on a day-to-day basis. For this reason perseverance in self-controlling efforts may be of crucial importance to language success. It allows for a steady linguistic and cultural development of the student, allowing him to enjoy diverse, even contradictory opinions, leading to ultimate language success. The results of the research carried out with Polish secondary grammar school students (N = 621) demonstrate that only in reference to self-assessment of FL skills students with high levels of self-regulated efficacy significantly…
Virtual Reality, Augmented Reality, and In Vivo Exposure Therapy: A Preliminary Comparison of Treatment Efficacy in Small Animal Phobia
2018
This study aggregated data from three randomized control trials to explore the differential efficacy of three forms of exposure therapy, namely, in vivo (iVET), virtual reality (VRET), and augmented reality (ARET), in the treatment of small animal phobia. Additionally, baseline patient characteristics were used to detect subgroups of patients who showed a differential response to certain treatment modalities. Primary measures were distance covered, anxiety during the behavioral avoidance test (BAT), and overall fear of small animals. A repeated-measures analysis of variance was used to explore the overall treatment effect across the exposure modalities. A cluster analysis and an analysis of…
Exploring the role of teachers’ attitudes towards inclusive education, their self-efficacy, and collective efficacy in behaviour management in teache…
2023
Using a sample of 384 Finnish teachers, in this study we explored how teachers' attitudes towards inclusive education, self-efficacy, and collective efficacy in behaviour management affect their behaviours in teaching appropriate behaviours to students, and how teachers' attitudes, self-efficacy, and collective efficacy mediate the effect of background variables on teacher behaviour. The results revealed that teachers’ self-efficacy and collective efficacy significantly predicted their behaviour. The number of students with attention or behavioural problems has an indirect negative effect on teacher behaviour, mediated by teacher self-efficacy. peerReviewed
The effect of perceived school climate and teacher efficacy in behavior management on job satisfaction and burnout: A longitudinal study
2016
Abstract This study investigated how perceived school climate affects teachers' job satisfaction and burnout and how self-efficacy and collective efficacy in behavior management mediate the effect of perceived school climate on job satisfaction and burnout. The questions were answered using longitudinal questionnaire data collected from 642 Finnish lower secondary school teachers. A structural equation model revealed that school climate had a positive effect, partly mediated by self-efficacy, on job satisfaction. Collective efficacy in student discipline did not explain either job satisfaction or burnout. Self-efficacy in managing behavior had a positive effect on job satisfaction and a neg…
Self-regulatory efficacy and sources of efficacy in elementary school pupils: Self-regulatory experiences in a population sample and pupils with atte…
2019
In this study, we examined self-regulatory efficacy and sources of self-efficacy (mastery experiences, vicarious experiences, social persuasion and physiological/emotional states) and the relationships between self-efficacy and its sources among elementary school pupils. Two groups were compared: a population sample (PS, N = 1284) and pupils with difficulties in attention and executive functions (AED, N = 61). Data gathered from self-report questionnaires indicated that pupils in the PS group had more positive efficacy beliefs and mastery experiences and fewer negative physiological/emotional states than the AED group. Analyses showed strong connections between sources and self-regulatory e…