Search results for " electrospinning"

Nanocarbons in electrospun polymeric nanomats for tissue engineering: A review

2017

Electrospinning is a versatile process technology, exploited for the production of fibers with varying diameters, ranging from nano- to micro-scale, particularly useful for a wide range of applications. Among these, tissue engineering is particularly relevant to this technology since electrospun fibers offer topological structure features similar to the native extracellular matrix, thus providing an excellent environment for the growth of cells and tissues. Recently, nanocarbons have been emerging as promising fillers for biopolymeric nanofibrous scaffolds. In fact, they offer interesting physicochemical properties due to their small size, large surface area, high electrical conductivity an…

Controlled Release of Metformin Hydrochloride from Core-Shell Nanofibers with Fish Sarcoplasmic Protein

2019

Ficai, Anton/0000-0002-1777-0525; Karademir, Betul/0000-0003-1762-0284 WOS:000503463400074 PubMed ID: 31658758 Background and Objectives: A coaxial electrospinning technique was used to produce core/shell nanofibers of a polylactic acid (PLA) as a shell and a polyvinyl alcohol (PVA) containing metformin hydrochloride (MH) as a core. Materials and Methods: Fish sarcoplasmic protein (FSP) was extracted from fresh bonito and incorporated into nanofiber at various concentrations to investigate the influence on properties of the coaxial nanofibers. The morphology, chemical structure and thermal properties of the nanofibers were studied. Results: The results show that uniform and bead-free struct…

Biodegradable Membrane with High Porosity and Hollow Structure Obtained via Electrospinning for Oil Spill Clean-up Application

2023

The use of biodegradable polymers for the production of membranes to be used in wastewater treatment has attracted increasing interest considering the possibility of reducing the risk of second pollution. In this work, porous fibrous membranes based on polylactic acid and polyethylene oxide (PEO) blends were prepared. The solutions were electrospun using two approaches: (i) conventional coaxial electrospinning followed by leaching treatment (double-step, DS); (ii) coaxial wet electrospinning with in situ leaching (single-step, SS). By varying PEO type and processing method it was possible to control membranes structure and porosity. DS leaching treatment lead to surface porosity (i.e. shell…

PLA/PCL nanofibrous blends via multi-jet electrospinning: processing-morphology-property relationships

2017

Electrospinning permits to prepare ultrafine fibers with micro to nano-meter range diameters. Multi-jet approaches can be used to fabricate blend nanofibrous mats composed by two or more polymers presenting different properties such as degradation rate, mechanical properties and so on. In this study, a series of PLA/PCL blend nanofiber mats were prepared by dual-jet electrospinning. The relative weight ratio of PLA and PCL in blend was controlled by changing the flow ratio of the two syringe pumps containing the polymer solutions.

Polybutylene Succinate Processing and Evaluation as a Micro Fibrous Graft for Tissue Engineering Applications

2022

A microfibrous tubular scaffold has been designed and fabricated by electrospinning using poly (1,4-butylene succinate) as biocompatible and biodegradable material. The scaffold morphology was optimized as a small diameter and micro-porous conduit, able to foster cell integration, adhesion, and growth while avoiding cell infiltration through the graft’s wall. Scaffold morphology and mechanical properties were explored and compared to those of native conduits. Scaffolds were then seeded with adult normal human dermal fibroblasts to evaluate cytocompatibility in vitro. Haemolytic effect was evaluated upon incubation with diluted whole blood. The scaffold showed no delamination, and mech…

Polybutylene succinate artificial scaffold for peripheral nerve regeneration

2021

Regeneration and recovery of nerve tissues are a great challenge for medicine, and positively affect the quality of life of patients. The development of tissue engineering offers a new approach to the problem with the creation of multifunctional artificial scaffolds that act on various levels in the damaged tissue, providing physical and biochemical support for the growth of nerve cells. In this study, the effects of the use of a tubular scaffold made of polybutylene succinate (PBS), surgically positioned at the level of a sciatic nerve injured in rat, between the proximal stump and the distal one, was investigated. Scaffolds characterization was carried out by scanning electron microscopy …

Influence of Nylon 6,6 nanofiber mats on cure behavior and properties of CFR epoxy resin

2014

In this work Nylon 6,6 nanofibrous mats produced by electrospinning were used as interlayers in carbon fiber reinforced laminates. A high crossilinked epoxy resin was chosen as matrix. The effects of polymeric mats on cure behavior, thermal and delamination properties of the composite laminates were investigated.

A hyaluronic acid derivative as a coating film for an electrospun cell releasing system in the treatment of corneal wounds

2017

The transparency of the cornea is maintained by the stem cells of the corneal epithelium in the limbal region; damage to the limbus may cause partial or total limbal stem cell deficiency that, may lead to blindness. The transplantation of cells is crucial to regenerate the damaged areas. The techniques currently employed consist in cadaveric corneal transplantation or in the use of amniotic membrane as a carrier for delivering cultured limbal stem cells to the cornea. Both these approaches show severe drawbacks such as the potential reject of the transplanted cornea and the risk of viral disease transmissions. Here we report the production of an electrospun device that could be exploited as…

Heparin functionalized polyaspartamide/polyester scaffold for potential blood vessel regeneration

2013

Physical and antibacterial properties of PLA electrospun mats loaded with carvacrol and nisin

2022

Functional, biopolymeric electrospun structures for the controlled release of antimicrobial agents are gaining in-creasing interest in food packaging applications. In this study, the physical and antibacterial performances of ternary systems composed of polylactic acid (PLA) electrospun mats loaded with 20 wt% of different relative amounts of carvacrol (CRV) and a commercial nisin formulation (Nis) were assessed. Scanning electron micrographs displayed micro-scaled fibers with different diameter size distributions depending on the relative concentrations of the additives. The PLA/CRV/Nis membranes??? wettability was affected by the relative amount of CRV and Nis loaded, switching from hydro…