Search results for " end"
showing 10 items of 4885 documents
Ethnic differences in serum lipoproteins and their determinants in South African women
2010
Hyaluronic acid and alpha-elastin based hydrogel for three dimensional culture of vascular endothelial cells
2018
Abstract The aim of this work was to demonstrate that employing a copolymer of hyaluronic acid and α-elastin (HA-EDA-g-α-elastin) is possible to produce a scaffold able to support the adhesion and growth of human vascular endothelial cells (HUVEC) thanks to its ability to incorporate and control the diffusion of vascular endothelial growth factor (VEGF). HA-EDA-g-α-elastin was crosslinked with low molecular weight hyaluronic acid (HALMW) to obtain a hydrogel that gives rise to the formation of three dimensional sponge after the freeze drying process. The physicochemical features the obtained material along with its ability to act as a support for the three dimensional culture of endothelial…
Antidiabetic Drugs in NAFLD: The Accomplishment of Two Goals at Once?
2018
Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common cause of chronic liver disease in Western countries, accounting for 20–30% of general population and reaching a prevalence of 55% in patients with type 2 diabetes mellitus (T2DM). Insulin resistance plays a key role in pathogenic mechanisms of NAFLD. Many drugs have been tested but no medications have yet been approved. Antidiabetic drugs could have a role in the progression reduction of the disease. The aim of this review is to summarize evidence on efficacy and safety of antidiabetic drugs in patients with NAFLD. Metformin, a biguanide, is the most frequently used drug in the treatment of T2DM. To date 15 randomized controlled t…
Real-time simulation of tissue deformation for the nasal endoscopy simulator (NES).
1999
Endonasal sinus surgery requires a great amount of training before it can be adequately performed. The complicated anatomy involved, the proximity of relevant structures, and the variability of the anatomy due to inborn or iatrogenic variations make several complications possible. Today, cadaver dissections are the "gold standard" for surgical training. To overcome the drawbacks of traditional training methods, the Fraunhofer Institute for Computer Graphics is currently developing a highly interactive medical simulation system for nasal endoscopy and endonasal sinus surgery, in cooperation with the Mainz University Hospital. For the simulation of a rhinoscopic procedure, not only are the re…
Comparison of the shear bond strength of 3D printed temporary bridges materials, on different types of resin cements and surface treatment
2019
Background Thus, purpose of this study was to compare the shear bond strength of the resin cement and the resin modified glass ionomer cement on 3D printed temporary material for crowns and bridges in combination with different surface treatment modalities. Material and methods Test specimens VarseoSmile Temp material (Bego, Bremen, Germany) (n=64) in the form of rectangular blocks (n=32) and cylindrical test specimens (n=32) were printed using the Varseo S 3D printer (Bego, Bremen, Germany). The specimens were divided into 4 groups, with 8 specimens of each kind. Two groups (n=16 pairs) were blasted with Perlablast® Micro [PM] 50µm (Bego, Bremen, Germany) and two groups (n=16 pairs) were b…
Post-Transcriptional Regulation of Iron Homeostasis in Saccharomyces cerevisiae
2013
Iron is an essential micronutrient for all eukaryotic organisms because it participates as a redox cofactor in a wide variety of biological processes. Recent studies in Saccharomyces cerevisiae have shown that in response to iron deficiency, an RNA-binding protein denoted Cth2 coordinates a global metabolic rearrangement that aims to optimize iron utilization. The Cth2 protein contains two Cx8Cx5Cx3H tandem zinc fingers (TZFs) that specifically bind to adenosine/uridine-rich elements within the 3' untranslated region of many mRNAs to promote their degradation. The Cth2 protein shuttles between the nucleus and the cytoplasm. Once inside the nucleus, Cth2 binds target mRNAs and stimulate…
Implicación de las quimoquinas IL-8, MCP-1, rantes, los receptores CXCR1, CXCR4, CCr2, CCr5 y el factor IGFBP-rP1 en la interfase materno-embrionaria
2003
La implantación embrionaria es la fijación del blastocisto al endometrio materno. El conocimiento de los factores moleculares implicados en su regulación es crucial para comprender los mecanismos que controlan la reproducción humana Las quimoquinas y sus receptores participan activamente en este proceso así como otros factores como IGFBP-rP1.Los objetivos principales de la tesis doctoral fueron los siguientes - Investigar la expresión y localización de la quimoquinas IL-8, MCP-1, RANTES y SDF-1 en el endometrio humano.- Estudiar la expresión y localización de los receptores de las quimoquinas antes citadas CXCR1, CCR2b, CCR5 y CXCR4 en el endometrio humano.- Determinar la presencia de dicho…
La delimitación del concepto de daño moral: un estudio de la cuestión en el ordenamiento jurídico español.
2021
El presente estudio tiene como objetivo realizar una aproximación al concepto de daño moral en el derecho español porque, a diferencia del daño patrimonial, el Código Civil no proporciona un concepto sobre él. Para la articulación de un concepto de daño moral es necesario analizar los supuestos de reconocimiento legal, la interpretación que los órganos judiciales han hecho y el tratamiento proporcionado en los Principios de derecho contractual europeo y de derecho de daños europeo. El trabajo finaliza con una valoración sobre la actual configuración del daño moral. The present study aims to make an approximation to the concept of non-pecuniary damage in Spanish law because, unlike property …
Futuro profesional de los menores y ejercicio de la patria potestad
2021
The personal decision about the professional future of the minor, constitutes an aspect of the development of his free personality, and, like every decision that affects him, it must be adopted considering the principle of the best interests of the child. The parents, in the exercise of parental authority, have the legal representation of their minor children, except for the acts related to the personality rights, which can be carried out by the minor child himself if he is mature enough. When personality rights and economic rights converge, it is necessary to determine the role the parents play, which in the end will always have to be the protection and respect for their children?s rights.
Liquidación de la sociedad de gananciales: el caso de la adjudicación forzosa de participaciones sociales de carácter ganancial a un solo cónyuge. Co…
2021
In a liquidation of community property, the rules for the partition of the inheritance are of suppletive application. Therefore, the sentence opts for a criterion of flexible interpretation of those rules, whose application will be subject to the objective entity of the property in question. Accordingly, when the only property to be shared between the spouses is constituted by set of shares of common nature, taking into account the special circumstances of the case, such shares could be awarded to one of the spouses with the obligation to compensate the other in money, even if it requests the sale of the shares in the public auction. To this end, the request would have to impede the possibi…