Search results for " engineering"
showing 10 items of 38291 documents
Kobieca strona dyskursu onkologicznego. Empiryczne spojrzenie na demokratyzację wiedzy medycznej
2015
Artykuł poprzez osadzanie w teoretycznych ramach konstruktywizmu wpisuje chorobę nowotworową piersi w kategorię dyskursu. Takie podejście wymaga zadania pytań o depozytariuszy wiedzy medycznej oraz jej źródła, formy i sposoby dystrybucji. Nie chodzi tu o negację istnienia określonych jednostek chorobowych, lecz raczej zwrócenie uwagi na złożone powiązania pomiędzy wiedzą medyczną a światem społecznym. Klarowny obraz obiektywnej wiedzy zaczyna tracić jednoznaczne kontury, gdy zestawi się alternatywne reprezentacje językowe w odmienny sposób porządkujące i interpretujące doświadczenia związane ze zdrowiem i chorobą. Na płaszczyźnie empirycznej analiza opiera się na wynikach badań ilościowych,…
Embracing iterations in Quantum software: a vision
2022
In today’s software engineering, iterations, affordable en masse, form an important part of just about any system. However, not all computing resources are cheap to consume. In High-Performance (HPC) and Quantum Computing (QC), executions can consume considerable amounts of energy and time, which is reserved and used even if the very first steps in the process fail. This means that developers must assume a different attitude towards programming, and aim at error-free software before its execution. This is com monly facilitated using simulators, which are commonplace for both HPC and QC. However the fashion developers advance from one tool to another is ad-hoc, with no established software e…
Novel qutrit circuit design for multiplexer, De-multiplexer, and decoder
2022
AbstractDesigning conventional circuits present many challenges, including minimizing internal power dissipation. An approach to overcoming this problem is utilizing quantum technology, which has attracted significant attention as an alternative to Nanoscale CMOS technology. The reduction of energy dissipation makes quantum circuits an up-and-coming emerging technology. Ternary logic can potentially diminish the quantum circuit width, which is currently a limitation in quantum technologies. Using qutrit instead of qubit could play an essential role in the future of quantum computing. First, we propose two approaches for quantum ternary decoder circuit in this context. Then, we propose a qua…
Combined Spectroscopic and TD-DFT Analysis to Elucidate Substituent and Acidochromic Effects in Organic Dyes: A Case Study on Amino- versus Nitro-Sub…
2020
Made available in DSpace on 2020-12-12T01:33:30Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01 A combined spectroscopic and TD-DFT case study was performed, to identify a robust method to calculate the complex near UV/Vis absorption spectra of various amino- vs. nitro-substituted 2,4-diphenylquinolines, which vary strongly under neutral and successively acidic conditions. For this, different DFT functionals were tested for geometry optimization and the TD part to calculate the neutral and different protonated species in a fast screening approach, i. e. using single point calculations in an implicit solvent. Offset-corrected M06HF, hitherto only applied to polymers, was identif…
Molecular Mechanisms of the Blockage of Glioblastoma Motility
2021
Glioblastoma (GBM) is the most common and lethal brain tumor. GBM has a remarkable degree of motility and is able to infiltrate the healthy brain. In order to perform a rationale-based drug-repositioning study, we have used known inhibitors of two small Rho GTPases, Rac1 and Cdc42, which are upregulated in GBM and are involved in the signaling processes underlying the orchestration of the cytoskeleton and cellular motility. The selected inhibitors (R-ketorolac and ML141 for Cdc42 and R-ketorolac and EHT 1864 for Rac1) have been successfully employed to reduce the infiltration propensity of GBM in live cell imaging studies. Complementarily, all-atom simulations have elucidated the molecular …
Radial symmetry of p-harmonic minimizers
2017
"It is still not known if the radial cavitating minimizers obtained by Ball [J.M. Ball, Discontinuous equilibrium solutions and cavitation in nonlinear elasticity, Phil. Trans. R. Soc. Lond. A 306 (1982) 557--611] (and subsequently by many others) are global minimizers of any physically reasonable nonlinearly elastic energy". The quotation is from [J. Sivaloganathan and S. J. Spector, Necessary conditions for a minimum at a radial cavitating singularity in nonlinear elasticity, Ann. Inst. H. Poincare Anal. Non Lineaire 25 (2008), no. 1, 201--213] and seems to be still accurate. The model case of the $p$-harmonic energy is considered here. We prove that the planar radial minimizers are indee…
High Bias Voltage CZT Detectors for High-flux Measurements
2017
In this work, we present the performance of new travelling heater method (THM) grown CZT detectors, recently developed at IMEM-CNR Parma, Italy. Thick planar detectors (3 mm thick) with gold electroless contacts on CZT crystals grown by Redlen Technologies (Victoria BC, Canada) were realized, with a planar cathode covering the detector surface (4.1 x 4.1 mm(2)) and a central anode (2 x 2 mm(2)) surrounded by a guard ring electrode. The detectors, characterized by low leakage currents at room temperature (4.7 nA/cm(2) at 1000 V/cm), allow good room temperature operation even at high bias voltages (> 7000 V/cm). At low rates, the detectors exhibit an energy resolution around 4 % FWIEM at 59.5…
Cost that is Directly Incurred as a Result of Operating the Train Service on the 1520 mm Rail with Primarily Freight Transportation
2016
AbstractUnder the Directive 2012/34/EU (21 November 2012) “the charges for … [rail] infrastructure … shall be set at the cost that is directly incurred as a result of operating the train service”. This charging rule is new for Baltic States’ railways, where due to the favorable geographic position a full cost application without detalization was possible. Although, a big number of relevant studies on the issue was made in EU, all of them covered only 1435mm railways with primarily passenger transportation. This study has been made in order to understand the impact of train operating on 1520mm rail infrastructure with primarily freight transportation.A gradual model of infrastructure chargin…
Automated Railway Signs Detection. Preliminary Results
2019
Abstract Nowadays safety in railways is mostly achieved by automated system technologies such as ERTMS/ETCS. Nevertheless, on local railways (suburban and regional lines) several tasks still depend on the choices and actions of a human crew. With the aim to improve safety in such type of railways, this research proposes a system for the automatic detection and recognition of railway signs by means of the digital image processing technique. First field applications, carried out on the Italian railway network, show that the proposed system is very accurate (the percentage of correctly detected railway signs is about 97%), even at high train speeds.
Generalized wave propagation problems and discrete exterior calculus
2018
We introduce a general class of second-order boundary value problems unifying application areas such as acoustics, electromagnetism, elastodynamics, quantum mechanics, and so on, into a single framework. This also enables us to solve wave propagation problems very efficiently with a single software system. The solution method precisely follows the conservation laws in finite-dimensional systems, whereas the constitutive relations are imposed approximately. We employ discrete exterior calculus for the spatial discretization, use natural crystal structures for three-dimensional meshing, and derive a “discrete Hodge” adapted to harmonic wave. The numerical experiments indicate that the cumulat…