Search results for " evaluation."
showing 10 items of 1351 documents
Integrating the human factor in FMECA-based risk evaluation through Bayesian networks
2020
The contribution of the present paper aims to develop the traditional Failure Modes, Effects and Criticality Analysis (FMECA) for quantitative risk analysis from a Bayesian Network (BN)-based perspective. The main purpose of research consists in providing a framework for analysing causal relationships for risk evaluation and deriving probabilistic inference among significant risk factors. These parameters will be represented by linguistic variables and will include the human factor as a key element of analysis. Traditional approaches for risk evaluation and management performed by FMECA [1] represent helpful tools to globally enhance systems and processes conditions [2]. However, such appro…
Discovery of benzimidazole-based Leishmania mexicana cysteine protease CPB2.8ΔCTE inhibitors as potential therapeutics for leishmaniasis
2018
Abstract: Chemotherapy is currently the only effective approach to treat all forms of leishmaniasis. However, its effectiveness is severely limited due to high toxicity, long treatment length, drug resistance, or inadequate mode of administration. As a consequence, there is a need to identify new molecular scaffolds and targets as potential therapeutics for the treatment of this disease. We report a small series of 1,2‐substituted‐1H‐benzo[d]imidazole derivatives (9ad) showing affinity in the submicromolar range (Ki = 0.150.69 μM) toward Leishmania mexicanaCPB2.8ΔCTE, one of the more promising targets for antileishmanial drug design. The compounds confirmed activity in vitro against intrace…
Bibliometric analysis of the Annual Review of Legal Psychology journal between 1991-2019
2021
[EN]: The present study carries out a bibliometric analysis of Annual Review of Legal Psychology from 1991 to 2019. Data were collected from a database that allows for the analysis of authors, institutions, countries, gender, topics, and impact. The results enable us to observe gender discrepancies among authors, with a a higher frequency of women (50.2%), and the number of signatures (53.7% men). Over the years there is an increase in the number of authors and signatures, of co-authorship, a higher presence of international signatures, representing 23.5% between 2011 and 2019. Three collaboration groups were identified, two from Spain and one from Colombia. Categories of Legal and Forensic…
Perfiles de personalidad y resiliencia en dolor crónico: utilidad del CDRISC-10 para discriminar los tipos resiliente y vulnerable
2019
espanolRESUMEN Introduccion: Uno de los aspectos psicologicos asociados a la vivencia del dolor cronico han sido los perfiles de personalidad y, relacionado con ellos, la resiliencia. En el dolor cronico la resiliencia se refiere tanto a la capacidad de volver atras tras el dano inicial como tambien a la de continuar con su funcionamiento habitual pese a la repeticion de los problemas. En este campo, sin embargo, no hay referencias sobre si la resiliencia se relaciona con los perfiles de personalidad. En trabajos previos se ha abordado la cuestion de los perfiles de personalidad relacionados con el dolor cronico. El objetivo de este trabajo es replicar los perfiles encontrados previamente, …
Evaluation of training in guideline-oriented biopsychosocial management of low back pain in occupational health services:Protocol of a cluster random…
2021
Background To prevent low back pain (LBP) from developing into a prolonged disabling condition, clinical guidelines advocate early stage assessment, risk‐screening, and tailored interventions. Occupational health services recommend guideline‐oriented biopsychosocial screening and individualized assessment and management. However, it is not known whether training a limited number of health care professionals improves the management process. The primary objective of this study is to investigate whether training in the biopsychosocial practice model is effective in reducing disability. Furthermore, we aim to evaluate health‐economic impacts of the training intervention in comparison to usual m…
Evaluating the effect of organization and context on technical efficiency: a second-stage DEA analysis of Italian hospitals
2022
Objective: the purpose of this study was to compare the technical efficiency of Italian hospitals at a regional level and to examine if differences could be explained by organisational and contextual factors. Technical efficiency was defined as the ability of the operating units evaluated to use optimal resource levels for their level of output.Methods: the effect of external factors was explored through a second stage Data Envelopment Analysis (DEA). Efficiency scores were calculated for each hospital using the DEA method (Stage I). Through Tobit regression analysis, the estimated efficiency scores were regressed against a set of organisational and contextual characteristics beyond manager…
Predictors of outcome in acute ischemic cerebrovascular syndromes: The GIFA study
2006
Abstract Background Today it may be more useful to use the term acute ischemic cerebrovascular syndrome (AICS) to define a spectrum of disease ranging from TIA to stroke and that share a similar underlying pathophysiology: cerebral ischemia . The aim of this study is to evaluate the prognostic importance of some demographic, laboratory and clinical variables on the outcome in hospitalized patients with a discharge diagnosis suggestive of acute ischemic cerebral syndrome (AICS). Methods 17,377 Subjects were enrolled in the GIFA study, a multicenter survey of hospitalized older patients. 1878 Subjects with a main discharge diagnosis suggestive of acute ischemic cerebrovascular syndrome (AICS)…
COX-1/COX-2 inhibitors based on the methanone moiety
2002
This paper focuses on the synthesis and the in vitro testing of dual COX-1/COX-2 inhibitors. Starting from structures of non-steroidal anti-inflammatory drugs (NSAIDs) the diaryl methanone element was chosen as a lead. Modifications were carried out on this scaffold to obtain potent inhibitors of the COX enzymes. The N-(2-aroylphenyl)sulphonamides and -amides were studied in detail, and to consolidate the data evaluated the corresponding 3- and 4-regioisomers were also investigated. The potency and the enzyme selectivity were varied by structural modifications of the lead.
In-vitro test system for the evaluation of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibitors based on a single HPLC run with UV detect…
2001
Objective and Design: The aim of this study was to develop a new, whole-cell test system which is easy to handle and requires a standard equipment for the parallel screening of COX-1 and COX-2 inhibitors.¶Materials: Bovine aortic endothelial cells (BAECs).¶Treatment and methods: Unstimulated bovine aortic coronary endothelial cells (BAECs) were used as a source of COX-1 and BAECs pretreated with ASA (100 μM) and activated with phorbol myristate acetate (PMA) were used as a source of COX-2. The time- and concentration-dependent induction of COX-2 expression in the BAECs was evaluated by a kinetic profile (HPLC analysis) and detected by Western-Blot analysis using polyclonal antibodies agains…
Managing Human Factors to Reduce Organisational Risk in Industry
2018
[EN] Human factors are intrinsically involved at virtually any level of most industrial/business activities, and may be responsible for several accidents and incidents, if not correctly identified and managed. Focusing on the significance of human behaviour in industry, this article proposes a multi-criteria decision-making (MCDM)-based approach to support organizational risk assessment in industrial environments. The decision-making trial and evaluation laboratory (DEMATEL) method is proposed as a mathematical framework to evaluate mutual relationships within a set of human factors involved in industrial processes, with the aim of highlighting priorities of intervention. A case study relat…