Search results for " evaluation."
showing 10 items of 1351 documents
Novel 4-(3-phenylpropionamido), 4-(2-phenoxyacetamido) and 4-(cinnamamido) substituted benzamides bearing the pyrazole or indazole nucleus: synthesis…
2019
Based on some common structural features of known compounds interfering with p53 pathways and our previously synthesized benzamides, we synthesized new ethyl 5-(4-substituted benzamido)-1-phenyl-1H-pyrazole-4-carboxylates 26a-c, ethyl 5-(4-substituted benzamido)-1-(pyridin-2-yl)-1H-pyrazole-4-carboxylates 27a-c and N-(1H-indazol-6-yl)-4-substituted benzamides 31a,b bearing in the 4 position of the benzamido moiety the 2-phenylpropanamido or 2-phenoxyacetamido or cinnamamido groups. A preliminary test to evaluate the antiproliferative activity against human lung carcinoma H292 cells highlighted how compound 26c showed the best activity. This last was therefore selected for further studies wi…
Ex ante evaluation of cropping systems for weed-mediated pests and environmental benefits with simulation–based indicators
2016
SPEEAGESTADAGROSUP; International audience; Integrated crop protection tolerates residual weed floras if they are not harmful for crop production. These weeds can host harmful crop pests, among which parasitic plants such as broomrape (Phelipanche ramosa). They can also contribute to reduce soil erosion as well as nitrate and pesticide leaching. To evaluate these weed impacts of management practices ex ante, we developed indicators for the weed dynamics model FLORSYS (Colbach et al., 2014) and then used the model to predict weed-mediated broomrape risk and environmental benefits in cropping systems from five French regions. Materials and Methods FLORSYS is a virtual field on which cropping …
IANUS: Comparative analysis
2002
Jointly with the application of IANUS model in the selected facilities, in WP4 Ambiente Italia has to produce an evaluation and comparison between different facilities and core indicators. The aim of this paper is to show collected data, computed indicators and comparison facilities throuh suggested indicator evaluation system.
Measuring the Change Towards More Sustainable Mobility:MUV Impact Evaluation Approach
2019
Urban areas can be considered the ground for the challenges related to the UN&rsquo
Including functional usability features in a Model-Driven Development Method
2013
The Software Engineering (SE) community has historically focused on working with models to represent functionality and persistence, pushing interaction modelling into the background, which has been covered by the Human Computer Interaction (HCI) community. Recently, adequately modelling interaction, and specifically usability, is being considered as a key factor for success in user acceptance, making the integration of the SE and HCI communities more necessary. If we focus on the Model-Driven Development (MDD) paradigm, we notice that there is a lack of proposals to deal with usability features from the very first steps of software development process. In general, usability features are man…
Introducing Usability in a Conceptual Modeling-Based Software Development Process
2012
Usability plays an important role to satisfy users? needs. There are many recommendations in the HCI literature on how to improve software usability. Our research focuses on such recommendations that affect the system architecture rather than just the interface. However, improving software usability in aspects that affect architecture increases the analyst?s workload and development complexity. This paper proposes a solution based on model-driven development. We propose representing functional usability mechanisms abstractly by means of conceptual primitives. The analyst will use these primitives to incorporate functional usability features at the early stages of the development process. Fo…
Current Advances in the Synthesis and Biological Evaluation of Pharmacologically Relevant 1,2,4,5-Tetrasubstituted-1H-Imidazole Derivatives
2019
:In recent years, the synthesis and evaluation of the biological properties of 1,2,4,5-tetrasubstituted-1H-imidazole derivatives have been the subject of a large number of studies by academia and industry. In these studies it has been shown that this large and highly differentiated class of heteroarene derivatives includes high valuable compounds having important biological and pharmacological properties such as antibacterial, antifungal, anthelmintic, anti-inflammatory, anticancer, antiviral, antihypertensive, cholesterol-lowering, antifibrotic, antiuricemic, antidiabetic, antileishmanial and antiulcer activities.:The present review with 411 references, in which we focused on the literatur…
An analysis of the scientific productivity and visibility of publications on usability (1971-2005)
2009
Aims: To analyse usability-related articles published in the period 1971-2005 from a bibliometric point of view. Methods: A search for articles was made in the CSIC databases, the Social Science Citation Index, Science Citation Index, PsycInfo, MEDLINE and Inspec databases, using ad hoc search strategies designed for each. Contribution, specific contribution and overlap indices were calculated, as were the indicators of change in scientific production, the productivity of institutions and journals, and the distribution of journals by area of knowledge. Results: An exponential increase in the number of published articles was recorded, with the highest increase seen over the last five years. …
A phase-II study of low-dose cyclophosphamide and recombinant human interleukin-2 in metastatic renal cell carcinoma and malignant melanoma.
1989
Recent preclinical and clinical studies that have demonstrated antitumor activity of high-dose recombinant interleukin-2 (rIL-2), and animal models that demonstrated a synergistic effect of low-dose cyclophosphamide, led us to study rIL-2 (Cetus Corp., Emeryville, Calif) in a phase II clinical trial in combination with low-dose cyclophosphamide in 32 patients, 18 with malignant melanoma and 14 with renal cell carcinoma. rIL-2 was given once daily at 3 x 10(6) U/m2, as a 30-min infusion for 14 days in cycle I and for 2 x 5 days in cycles II and III respectively; if tolerated, the dose was increased to a maximum of 6 x 10(6) U m-2 day-1; the cycles, separated by 1 week treatment-free interval…
AnyDSL: a partial evaluation framework for programming high-performance libraries
2023
This paper advocates programming high-performance code using partial evaluation. We present a clean-slate programming system with a simple, annotation-based, online partial evaluator that operates on a CPS-style intermediate representation. Our system exposes code generation for accelerators (vectorization/parallelization for CPUs and GPUs) via compiler-known higher-order functions that can be subjected to partial evaluation. This way, generic implementations can be instantiated with target-specific code at compile time. In our experimental evaluation we present three extensive case studies from image processing, ray tracing, and genome sequence alignment. We demonstrate that using partial …