Search results for " evaluation."

Fingolimod (FTY720-P) Does Not Stabilize the Blood–Brain Barrier under Inflammatory Conditions in an in Vitro Model

2015

Breakdown of the blood-brain barrier (BBB) is an early hallmark of multiple sclerosis (MS), a progressive inflammatory disease of the central nervous system. Cell adhesion in the BBB is modulated by sphingosine-1-phosphate (S1P), a signaling protein, via S1P receptors (S1P\(_1\)). Fingolimod phosphate (FTY720-P) a functional S1P\(_1\) antagonist has been shown to improve the relapse rate in relapsing-remitting MS by preventing the egress of lymphocytes from lymph nodes. However, its role in modulating BBB permeabilityin particular, on the tight junction proteins occludin, claudin 5 and ZO-1has not been well elucidated to date. In the present study, FTY720-P did not change the transendotheli…

EFFECT OF ADDING SOLID AND MOLTEN CHOCOLATE ON THE POLYPHENOL CONTENT, CHEMICAL, TEXTURAL, MICROBIOLOGICAL AND SENSORY ASPECTS OF PECORINO SICILIANO …

In this project we used two specific food products, which are typically Sicilian, Pecorino Siciliano cheese and Modica chocolate, that have unique texture and taste. “Chocolate cheese” is produced with the aim of increasing the consumption of cheese especially among children, targeting the purpose of improving public health. In this research we investigated chocolate cheese including solid and molten chocolate in three levels of 5%, 10% and 15% at four ripening times (T0 = fresh, T1 = 2 weeks, T2 = 4 weeks and T3 = 6 weeks). The results showed that the addition of chocolate significantly (p ≤ 0.05) decreased the pH, ash and protein content of the Pecorino Siciliano cheese, whereas it had no…

Evaluation of a rapid antigen detection test (Panbio™ COVID‐19 Ag Rapid Test Device) as a point‐of‐care diagnostic tool for COVID‐19 in a pediatric e…

2021

Abstract We evaluated the Panbio™ COVID‐19 Ag Rapid Test Device as a point‐of‐care diagnostic tool for COVID‐19 in 357 patients at a pediatric emergency department. Thirty‐four patients tested positive by reverse transcription polymerase chain reaction, of which 24 were positive by the antigen assay. The sensitivity and specificity of the assay were 70.5% and 100%, respectively.

Age- and Sex-Graded Data Evaluation of Vaccination Reactions after Initial Injection of the BNT162b2 mRNA Vaccine in a Local Vaccination Center in Ge…

2021

A high vaccination rate of older and particularly chronically ill people against coronavirus disease-2019 (COVID-19) is likely one of the most important factors in containing the pandemic. When Germany’s vaccination campaign started on December 2020, vaccination prioritization was initially carried out starting with older population groups. Side effect rates in 1065 individuals who had received the first dose of the messenger ribonucleic acid (mRNA) vaccine BNT162b2 Tozinameran from BioNTech/Pfizer three weeks earlier were examined retrospectively. An age- and gender-graded data analysis showed clear age and gender differences with regard to vaccine-related adverse effects. In 77% of all in…

Swallowing evaluation with videofluoroscopy in the paediatric population

2017

Valutazione della funzione deglutitoria in videofluoroscopia nei pazienti pediatrici.I disturbi della deglutizione in età pediatrica possono essere dovuti a diverse cause, dalla condizione di prematurità e patologie malformative sino al reflusso gastro-esofageo o a patologie infettive od infiammatorie del primo tratto gastroenterico. Nei neonati il processo della deglutizione è involontario e basato su meccanismi riflessi. In seguito, nell’ infanzia, la fase orale diventa volontaria , mentre le fasi faringea ed esofagea rimangono involontarie. I disordini della deglutizione possono severamente compromettere le capacità respiratorie e l’apporto nutrizionale dei pazienti pediatrici. La videof…

Determination of thyroid volume in infants with suspected congenital hypothyroidism—the limitations of both subjective and objective evaluation

2020

Objective: To compare two methods of assessing gland size on thyroid ultrasound in newborn infants with suspected congenital hypothyroidism (CH). Methods: Images from infants with eutopic glands referred between 2007 and 2013 were evaluated blind by two sets of observers. Subjective gland size was categorised as small, borderline-small, normal, borderline-large and large. Objective gland volume, calculated as the sum of each lobe using the prolate ellipsoid formula (length x width x depth x π/6), was put into corresponding categories: <0.8, 0.81–1.0, 1.1– <2.2, 2.2–2.4 and >2.4 ml, derived from normative Scottish data. Results: Of 36 infants, permanent CH was present in 17, transie…

Ocular Motor Paroxysmal Events in Neonates and Infants: A Review of the Literature

2021

Abstract Background Ocular paroxysmal events can accompany a variety of neurological disorders. Particularly in infants, ocular paroxysmal events often represent a diagnostic challenge. Distinguishing between epileptic and nonepileptic events or between physiological and pathologic paroxysmal events can be challenging at this age because the clinical evaluation and physical examination are often limited. Continuous polygraphic video-electroencephalography (EEG) monitoring can be helpful in these situations. Methods We review ocular paroxysmal events in newborns and infants. The aim is to improve clinical recognition of ocular paroxysmal events and provide a guide to further management. Usin…

Il processo di desertificazione per erosione di massa nel territorio “Alto Belice Corleonese” (Sicilia occidentale).

2008

Gestione dell’irrigazione con acque salmastre ed evoluzione della salinita’ dei suoli in un versante sito in agro di Castelvetrano (Trapani-Sicilia).

2010

An Experimental Characterization of Time of Arrival Accuracy for Time Synchronization of Medium Voltage Smart Grid Solutions

2019

The time synchronization of smart grid devices is a critical feature for the successful application of advanced grid monitoring and control techniques. Synchronization mechanisms based on the accurate estimation of the Time of Arrival (ToA) of network messages - sent over power line cables - are a promising solution to achieve synchronization tasks over distribution lines. In this paper, a chirp-based synchronization technique over the Medium Voltage (MV) grid has been proposed and characterized. Such approach has the benefit of not requiring the installation of a dedicated infrastructure, thanks to the exploitation of power distribution lines for the transmission of time synchronization da…