Search results for " evidence"

Fine slicing of the value chain and offshoring of essential activities: empirical evidence from European multinationals

2014

The offshoring of more advanced activities is increasing and a debate about the limits of offshoring has emerged. Companies are fine-slicing their value chains, and moving beyond the offshoring of peripheral and non-core activities to the offshoring of advanced and essential activities that are closer to their core (e.g. research, design and product development). The challenge is to understand the limits of offshoring and the most appropriate modes of offshoring. The purpose of this paper is to analyze what activities are offshorable and how best to govern offshored activities. We argue that companies are redefining their core activities and in this process, some essential activities previo…

Investment in Design and Firm Performance: The Mediating Role of Design Management

2009

Design management is an increasingly important concept, research into which is remarkably scarce. Although the literature suggests that design management has an effect on design effectiveness, there is no empirical support for the impact of design management on firm performance. Furthermore, few studies have quantified the contribution that design makes to company performance. The aim of this paper is to analyze the effect of design investment on company performance and how this relationship is mediated by design management skills. Structural equation modeling was used to test the research hypotheses on a data set from the Italian and Spanish ceramic tile industry. Results suggest, first, t…

Dialogic Feminist Gatherings: Impact of the Preventive Socialization of Gender-Based Violence on Adolescent Girls in Out-of-Home Care

2020

Gender-based violence is a social scourge with an increasing incidence at younger ages. Many studies have focused on finding effective solutions for overcoming this problem

What Counts in the Politics of Climate Change? Science, Scepticism and Emblematic Numbers

2019

Scientific data is frequently presented in climate policy in the form of targets, thresholds and other “emblematic numbers”. Emblematic numbers provide putatively accurate, easily graspable units of comparison. Their use, however, belies the complexity of climate change and scientific data and threatens to mask the political decisions that operate behind them. Those interested in disrupting policymaking are able to expose and exploit this masked politicisation. This contribution unpicks the ambiguous politics of emblematic numbers. A Qualitative Content Analysis of the 2015 NIPCC report reveals the tactics of a climate change denial organisation to target the politics behind “97%” and “95%”…

Balancing and clustering of words in the Burrows–Wheeler transform

2011

AbstractCompression algorithms based on Burrows–Wheeler transform (BWT) take advantage of the fact that the word output of BWT shows a local similarity and then turns out to be highly compressible. The aim of the present paper is to study such “clustering effect” by using notions and methods from Combinatorics on Words.The notion of balance of a word plays a central role in our investigation. Empirical observations suggest that balance is actually the combinatorial property of input word that ensure optimal BWT compression. Moreover, it is reasonable to assume that the more balanced the input word is, the more local similarity we have after BWT (and therefore the better the compression is).…

DNA Evidence Uncompromised by Active Oxygen

2010

Currently, forensic sciences can make use of the potential of instrumental analysis techniques to obtain information from the smallest, even invisible, samples. However, as laboratory techniques improve, so too should the procedures applied in the search for and initial testing of clues in order to be equally effective. This requires continuous revision so that those procedures may resolve the problems that samples present. As far as bloodstains are concerned, there are methods available that are recognized as being both highly sensitive and effective. Nevertheless, the marketing of new cleaning products, those that contain active oxygen, has raised doubts about the ability of those procedu…

Domestic violence in light of the Istanbul Convention: some procedural issues

2021

The paper concerns domestic violence (DV) and focuses on the connected criminal procedure topics. Following an attempt to define DV, the second part of the paper concerns the profile of the victim. The third part of the paper highlights two procedural issues, namely the complaint and the evidence. After that, the duty of the States to grant legal aid is considered.

Targeting apoptosis in solid tumors: the role of bortezomib from preclinical to clinical evidence.

2007

The ubiquitin-proteasome pathway is the main proteolytic system present in the nucleus and cytoplasm of all eukaryotic cells. Apoptosis activation induced by ubiquitin-proteasome pathway inhibition makes the proteasome a new target of anticancer therapy. Bortezomib is the first proteasome inhibitor to be approved by the US FDA; in 2003 as a third line and in 2005 as a second line therapy for the treatment of multiple myeloma only. This review focuses on the use of bortezomib, not only in its therapeutic role but also, more specifically, in its biologic role and discusses the most recent applications of the drug in solid tumors, both at a preclinical and clinical level.

Evidence-based practice (EBP)

2012

A multicriteria extension of the efficient market hypothesis

2021

Challenging the Efficient Market Hypothesis (EMH) has been a recurrent topic for researchers and practitioners since its formulation. Hundreds of empirical studies claim to either prove or disprove the EMH by means of a number of heterogeneous methods. Even though the EMH is usually adjusted to a measure of risk, there is a lack of a formal analysis within a multiple-criteria context. In this paper, we propose a extension of the EMH that accommodates the foundations of multiple-criteria decision analysis. To this end, we rely on a family of parametric signed dissimilarity measures to assess multidimensional performance differences. Since normalization is a critical step in our approach to a…