Search results for " exposure"
showing 10 items of 1011 documents
Astrocytes play an active role in persistence of respiratory augmentation in the recovery phase after hypoxic exposure
2020
128 Development of a job-exposure matrix (JEM) to describe pesticide exposure in Spanish workers (1996–2005)
2013
Objectives Pesticides are intensively used in Spain in a wide range of economic activities such as agriculture, farming, wood treatments or pest control, reaching in 2005 a consumption of more than 100,000 ton/year. Exposure to these substances has been proven to have negative effects on human health. However, there is little information available regarding the levels and frequency of exposure for workers, or the job titles associated with the worst exposure indicators. This study aimed to collect the available information on occupational pesticide exposure in Spain as a job-exposure matrix (JEM). Methods The work was carried out in the context of MatEmESp Project, which aims to build a Spa…
Occupational hygiene in a Finnish drum composting plant
2005
Bioaerosols (microbes, dust and endotoxins) and volatile organic compounds (VOCs) were determined in the working air of a drum composting plant treating source-separated catering waste. Different composting activities at the Oulu drum composting plant take place in their own units separated by modular design and constructions. Important implication of this is that the control room is a relatively clean working environment and the risk of exposure to harmful factors is low. However, the number of viable airborne microbes was high both in the biowaste receiving hall and in the drum composting hall. The concentration (geometric average) of total microbes was 21.8 million pcs/m3 in the biowaste…
Prenatal exposure to cannabinoids evokes long-lasting functional alterations by targeting CB 1 receptors on developing cortical neurons
2015
The CB1 cannabinoid receptor, the main target of Δ(9)-tetrahydrocannabinol (THC), the most prominent psychoactive compound of marijuana, plays a crucial regulatory role in brain development as evidenced by the neurodevelopmental consequences of its manipulation in animal models. Likewise, recreational cannabis use during pregnancy affects brain structure and function of the progeny. However, the precise neurobiological substrates underlying the consequences of prenatal THC exposure remain unknown. As CB1 signaling is known to modulate long-range corticofugal connectivity, we analyzed the impact of THC exposure on cortical projection neuron development. THC administration to pregnant mice in…
Examining the association between exposome score for schizophrenia and functioning in schizophrenia, siblings, and healthy controls: results from the…
2021
European Community's Seventh Framework Program, European Commission [HEALTH-F2-2009-241909]; Scientific and Technological Research Council of Turkey, 2219 International Postdoctoral Research Fellowship Program; Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III (SAM16PE07CP1, PI16/02012, and PI19/024)...
Maximum exposure levels for xylene, formaldehyde and acetaldehyde in cars.
2004
Although millions of individuals are exposed to emissions from articles inside cars, relatively little has been published about possible adverse health effects and about exposure levels that can be considered safe or "acceptable". Xylene, formaldehyde and acetaldehyde represent typical examples of relevant volatile organic substances (VOC) released from articles inside cars. Recently, a concept for derivation of maximum exposure levels for volatile organic substances in cars has been published. In the present study we applied this concept to derive maximum exposure levels for xylene, formaldehyde and acetaldehyde and compared the resulting concentrations to exposure levels usually found ins…
A new equipment to measure the combined effect of humidity, temperature, mechanical stress and UV exposure on the creep behaviour of polymers
2008
To be able to study and predict the physical properties of a polymeric material under different environmental conditions is very important. Moisture, UV irradiation, thermal and mechanical stresses can dramatically change the characteristics of the material and hinder some specific applications. In this work, a new equipment able to perform creep tests under different environmental conditions (temperature, humidity, stress) is presented. Some preliminary results are also presented using a sample of polyamide 6. As this polymer is sensitive to all these variables, it is appropriate to verify the effectiveness of the new instrument.
Addressing Exposome: An Innovative Approach to Environmental Determinants in Pediatric Respiratory Health
2022
Developmental age is particularly vulnerable to impacts of environmental exposures. Until recent years, the field of environment and child health has predominantly relied on the study of single exposure–health effect relationships. The exposome is an emerging concept in epidemiology, encompassing the totality of the exposures experienced by an individual throughout life and their changes over time. This innovative approach provides a risk profile instead of individual predictors. Exposome research may contribute to better understand the complex relationships between environmental exposures and childhood respiratory health, in order to implement prevention strategies and mitigate adverse hea…
Le bruit en milieu urbain : bruit et scolarité à Besançon
2009
SULT1A1 gene deletion in BRCA2-associated male breast cancer: a link between genes and environmental exposures?
2013
SULT1A1, a member of sulfotransferase superfamily, is a drug and hormone metabolizing enzyme involved in the metabolism of a variety of potential mammary carcinogens of endogenous and exogenous origin. Interestingly, the metabolic activity of SULT1A1 can be affected by varia- tions in gene copy number. Male Breast Cancer (MBC) is a rare disease and less investigated disease compared to female BC (FBC). As in FBC, the concurrent effects of genetic risk factors, particularly BRCA2 mutations, increased exposure to estrogens and environmental carcinogens play a relevant role in MBC. By quantitative real-time PCR with TaqMan probes, we investigated the presence of SULT1A1 gene copy number variat…