Search results for " expression"

Functions of the translation factor eIF5A in cellular metabolism and transcriptional control

2023

El factor de inicio de traducción de eucariotas 5A (eIF5A) es una proteína esencial y conservada con funciones en las tres fases de la traducción. eIF5A está codificado por dos genes parálogos, TIF51A/TIF51B y EIF5A1/EIF5A2 en levadura y humanos respectivamente. eIF5A es la única proteína que contiene hipusina, una modificación esencial para su actividad, y se une a los ribosomas para facilitar la traducción de motivos con prolinas consecutivas o combinaciones de prolina con glicina y aminoácidos cargados. eIF5A participa en otras funciones y procesos como exporte de mRNAs nucleares, proliferación y apoptosis. Su asociación con enfermades como el cáncer es de interés. En esta tesis se han u…

Influence of Musical Context on the Perception of Emotional Expression of Music

2013

Factors determining and influencing the perception of emotional expression of music include those related to music itself, to the listener, and to the context. Among the latter there is also music, as we rarely listen to a single piece. A simple experimental study has been carried out into the effect of music listened to immediately beforehand on the perception of the emotional expression of a musical piece. The following variables were involved: type of emotional expression of music conceived in terms of a most basic sad-joyful dimension, initial and final mood of the listeners, their professional musical education vs. lack thereof, age, and gender. The subjects were students of three age …

A Comparative Analysis of Piotr Borkowski's (1963) and Roman Gajda's (1970) English–Polish Phraseological Dictionaries: Practice vs. Theory

2022

This paper offers an insight into the short and largely unexplored history of English–Polish and Polish–English phraseological lexicography. It aims to analyse two post-war English–Polish phraseological dictionaries, An English–Polish Dictionary of Idioms and Phrases (1963) by Piotr Borkowski and Wybór idiomów angielskich [A Selection of English Idioms] (1970) by Roman Gajda, from a qualitative and quantitative perspective. At first sight, they seem to share several features, insofar as both are monoscopal English–Polish volumes of a similar size; both were addressed to Polish learners of English; and both drew on The Kosciuszko Foundation Dictionary: English–Polish (1959), an exhaustive re…

25th Lexis and Grammar Conference

2008

Conclusion: Lessons Learnt With and Through Visual Narratives of Lived Multilingualism, and a Research Agenda

2019

Zur Sprache des deutschen Bürgerlichen Gesetzbuches : wie fest sind die Mehrwortverbindungen im BGB?

2015

On the language of the German Bürgerliches Gesetzbuch: How stable are the multiword expressions in the Civil Code? The aim of this paper is to characterize the language of the German Civil Code with a focus on multiword expressions, exploring how common these multiword expressions are in modern German and examining their replacement by other combinations. The analysis focuses on the relative stability of these expressions in the sense of Kjær (1992 and 1994)

Myostatin/activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice

2015

Duchenne Muscular Dystrophy is characterized by muscle wasting and decreased aerobic metabolism. Exercise and blocking of myostatin/activin signaling may independently or combined counteract muscle wasting and dystrophies. The effects of myostatin/activin blocking using soluble activin receptor-Fc (sActRIIB-Fc) administration and wheel running were tested alone or in combination for seven weeks in dystrophic mdx mice. Expression microarray analysis revealed decreased aerobic metabolism in the gastrocnemius muscle of mdx mice compared to healthy mice. This was not due to reduced home-cage physical activity, and was further downregulated upon sActRIIB-Fc treatment in enlarged muscles. However…

ShRNA-mediated knock-down of CXCL8 inhibits tumor growth in colorectal liver metastasis.

2018

CXCL8 belongs to proinflammatory chemokines that are predominantly involved in neutrophil chemotaxis and degranulation. Several studies have suggested that secretion of CXCL8 from cancer cells have a profound effect on tumor microenvironment. In this study, in continuation to our previous work of understanding the global picture of invasion related genes in colorectal liver metastases, we clearly show an up-regulation of CXCL8 expression in the tumor cells at the invasion front as compared to the tumor cells in the inner parts of the tumor. Furthermore, ShRNA mediated down-regulation of CXCL8 resulted in inhibition of cell proliferation, viability and invasion in vitro and a near complete g…

Myotonic dystrophy: candidate small molecule therapeutics

2017

Myotonic dystrophy type 1 (DM1) is a rare multisystemic neuromuscular disorder caused by expansion of CTG trinucleotide repeats in the noncoding region of the DMPK gene. Mutant DMPK transcripts are toxic and alter gene expression at several levels. Chiefly, the secondary structure formed by CUGs has a strong propensity to capture and retain proteins, like those of the muscleblind-like (MBNL) family. Sequestered MBNL proteins cannot then fulfill their normal functions. Many therapeutic approaches have been explored to reverse these pathological consequences. Here, we review the myriad of small molecules that have been proposed for DM1, including examples obtained from computational rational …

Derepressing muscleblind expression by miRNA sponges ameliorates myotonic dystrophy-like phenotypes in Drosophila

2016

AbstractMyotonic Dystrophy type 1 (DM1) originates from alleles of the DMPK gene with hundreds of extra CTG repeats in the 3′ untranslated region (3′ UTR). CUG repeat RNAs accumulate in foci that sequester Muscleblind-like (MBNL) proteins away from their functional target transcripts. Endogenous upregulation of MBNL proteins is, thus, a potential therapeutic approach to DM1. Here we identify two miRNAs, dme-miR-277 and dme-miR-304, that differentially regulate muscleblind RNA isoforms in miRNA sensor constructs. We also show that their sequestration by sponge constructs derepresses endogenous muscleblind not only in a wild type background but also in a DM1 Drosophila model expressing non-co…