Search results for " fatty acid"
showing 10 items of 498 documents
Substrate specificity overlap and interaction between Adrenoleukodystrophy protein (ALDP/ABCD1) and Adrenoleukodystrophy-related protein (ALDRP/ABCD2)
2011
X-linked adrenoleukodystrophy (X-ALD) is a neurodegenerative disorder caused by mutations in the ABCD1 gene, which encodes a peroxisomal member of the ATP-binding cassette (ABC) transporter subfamily D called ALDP. ALDP is supposed to function as a homodimer allowing the entry of CoA-esters of very-long chain fatty acids (VLCFA) into the peroxisome, the unique site of their β-oxidation. ALDP deficiency can be corrected by overexpression of ALDRP, its closest homolog. However, the exact nature of the substrates transported by ALDRP and its relationships with ALDP still remain unclear. To gain insight into the function of ALDRP, we used cell models allowing the induction in a dose-dependent m…
Evidence of oxidative stress in very long chain fatty acid--treated oligodendrocytes and potentialization of ROS production using RNA interference-di…
2011
X-linked adrenoleukodystrophy (X-ALD) and pseudo neonatal adrenoleukodystrophy (P-NALD) are neurodegenerative demyelinating diseases resulting from the functional loss of the peroxisomal ATP-binding cassette transporter D (ABCD1) and from single peroxisomal enzyme deficiency (Acyl-CoA oxidase1: ACOX1), respectively. As these proteins are involved in the catabolism of very long chain fatty acids (VLCFA: C24:0, C26:0), X-ALD and P-NALD patients are characterized by the accumulation of VLCFA in plasma and tissues. Since peroxisomes are involved in the metabolism of reactive oxygen species (ROS) and nitrogen species (RNS), we examined the impact of VLCFA on the oxidative status of 158N murine o…
Study of the origin and fate of organic matter in a tropical bay using elemental, isotopic and fatty acid biomarkers.
2014
Organic matter (OM) exchanges between adjacent coastal ecosystems affect the role of the different primary producers as energy and nutrient sources in food webs. Elemental and isotope parameters (C/N ratios, δ13C) and fatty acid (FA) biomarkers were used to assess the origin and distribution of OM in both surface sediment and water along a strongly tidally-influenced tropical area, Gazi Bay (Kenya), in two climatic seasons (dry and rainy). Dominant primary producers (i.e. mangroves, macroalgae and seagrasses) were also characterized through the same combined approach. Export of the mangrove-derived OM, highly depleted, to the adjacent bay was evident from a gradual 13C-enrichment of primary…
Biocontrol of drosophila suzukii by two fatty acids
2020
International audience; Olfaction is a crucial sense for insects to detect food, seek partners or escape dangers. Volatile molecules are mainly perceived through insects' antenna. Odors bind to specific olfactory receptors located in sensilla. Olfactory sensory neurons then synapse on corresponding specific glomeruli of the antennal lobe, the primary olfaction center. This olfactory information is processed in higher centers to trigger a behavioral response. Understanding how odors can influence insect behavior is fundamental in order to protect cultures from pests. In this work, 2 volatile fatty acids are shown to modify significantly Drosophila suzukii courtship and copulation at increasi…
Effects of Genotype and Climate on Productive Performance of High Oleic Carthamus tinctorius L. under Rainfed Conditions in a Semi-Arid Environment o…
2023
Safflower (Carthamus tinctorius L.) is a promising oilseed crop for cultivation in central Southern Italy due to its high tolerance to drought and salinity stress and appreciable seed and oil yields. The genetic diversity of cultivars and climate factors can affect fatty acid composition and yield traits. This study aimed to assess the effects of genotype and climate conditions on the productive performance of eight high oleic safflower genotypes under rainfed conditions in Sicily (Italy). These genotypes were compared to the Montola 2000 cultivar, which was used as a reference. Tests were carried out during the growing seasons of 2014–2015 and 2015–2016. The experimental design…
Omega-3 Long-Chain Polyunsaturated Fatty Acids Intake in Children with Attention Deficit and Hyperactivity Disorder
2019
Omega-3 long-chain polyunsaturated fatty acids (LC-PUFA) play a central role in neuronal growth and in the development of the human brain, and a deficiency of these substances has been reported in children with attention deficit hyperactive disorder (ADHD). In this regard, supplementation with omega-3 polyunsaturated fatty acids is used as adjuvant therapy in ADHD. Seafood, particularly fish, and some types of nuts are the main dietary sources of such fatty acids in the Spanish diet. In order to assess the effect of the intake of common foods containing high amounts of omega-3 polyunsaturated fatty acids, a food frequency questionnaire was administered to parents of children with ADHD (N = …
The efficacy and safety of nutrient supplements in the treatment of mental disorders: a meta‐review of meta‐analyses of randomized controlled trials
2019
The role of nutrition in mental health is becoming increasingly acknowledged. Along with dietary intake, nutrition can also be obtained from "nutrient supplements", such as polyunsaturated fatty acids (PUFAs), vitamins, minerals, antioxidants, amino acids and pre/probiotic supplements. Recently, a large number of meta-analyses have emerged examining nutrient supplements in the treatment of mental disorders. To produce a meta-review of this top-tier evidence, we identified, synthesized and appraised all meta-analyses of randomized controlled trials (RCTs) reporting on the efficacy and safety of nutrient supplements in common and severe mental disorders. Our systematic search identified 33 me…
Production, oxidation traits and health of dairy ewes fed diets supplemented with fungus myceliated grains.
2019
Mushrooms contain many bioactive compounds, mainly poly- and oligosaccharides, known to have benefits for human health. Polysaccharides from mushrooms exhibited immunomodulatory, antibacterial, antiviral, and antifungal properties, as well as antitumor activity. Furthermore, some mushrooms showed to have potent antioxidant properties due to the presence of phenolic acids, flavonoids, polysaccharides, carotenoids, ascorbic acid, and tocopherols. These beneficial properties of mushrooms bioactive compounds indicate their potential use as performance-enhancing natural feed additives for livestock animals. In this regard, the use of mushrooms and mushroom-derived products has largely been inves…
Involvement of Lipoxygenase-dependent Production of Fatty Acid Hydroperoxides in the Development of the Hypersensitive Cell Death induced by Cryptoge…
1999
Lipid peroxidation was investigated in relation with the hypersensitive reaction in cryptogein-elicited tobacco leaves. A massive production of free polyunsaturated fatty acid (PUFA) hydroperoxides dependent on a 9-lipoxygenase (LOX) activity was characterized during the development of leaf necrosis. The process occurred after a lag phase of 12 h, was accompanied by the concomitant increase of 9-LOX activity, and preceded by a transient accumulation of LOX transcripts. Free radical-mediated lipid peroxidation represented 10% of the process. Inhibition and activation of the LOX pathway was shown to inhibit or to activate cell death, and evidence was provided that fatty acid hydroperoxides ar…
Relationship between rat liver microsomal Δ6 and Δ5 desaturase activities and fatty acid composition: comparative effects of coconut and salmon oils …
1992
International audience; The aim of this work was to compare the effects of coconut and salmon oils on rat liver microsomal Δ6 and Δ5 desaturations, during protein restriction. A higher Δ6 desaturase activity was noted in rats fed the low-protein coconut oil diet, in comparison with that occurring in rats fed either a low-protein or normal-protein salmon oil diet. No variation was observed in Δ5 desaturase activity or in 20:4n-6/ 18:2n-6 ratio. The fatty acid composition of liver microsomal phospholipids provided evidence of higher levels of 20:5n-3 and 22:6n-3 in the normal-protein salmon oil group, when compared with the low-protein salmon oil group. No influence of experimental diets on t…