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showing 10 items of 22510 documents

Real-world experience with obeticholic acid in patients with primary biliary cholangitis

2021

Background & aims Obeticholic acid (OCA) is the second-line treatment approved for patients with primary biliary cholangitis (PBC) and an inadequate response or intolerance to ursodeoxycholic acid. We aimed to evaluate the effectiveness and safety of OCA under real-world conditions. Methods Patients were recruited into the Italian PBC Registry, a multicentre, observational cohort study that monitors patients with PBC at national level. The primary endpoint was the biochemical response according to Poise criteria; the secondary endpoint was the biochemical response according to normal range criteria, defined as normal levels of bilirubin, alkaline phosphatase (ALP), and alanine aminotransfer…

upper limit of normalCirrhosisALTAMAAutoimmunityantinuclear antibodiesULNPBCGastroenterologyUDCASettore MED/12ULN upper limit of normalobeticholic acidaRR adjusted risk ratio.CRFs case record formAST aspartate transferaseClinical endpointGGT gamma-glutamyl transferaseQCprimary biliary cholangitisGastroenterologyUrsodeoxycholic acidANATCCCirrhosisCholestasiTIPSTreatment Completer CohortANA antinuclear antibodiemedicine.medical_specialtyRRUDCA ursodeoxycholic acidTIPS transjugular intrahepatic portosystemic shuntOCACirrhosiALP alkaline phosphataseautoimmune hepatitismedicine.diseasedigestive system diseasesDiscontinuationKeywords: AIH autoimmune hepatitiQC quality controlchemistrygamma-glutamyl transferaserandomised controlled trialelectronic data captureantimitochondrial antibodiesaspartate transferaseAutoimmune hepatitischemistry.chemical_compoundAIHCRFsImmunology and Allergyadjusted risk ratioANA antinuclear antibodiesRR risk ratioOverall cohortALT alanine transferaseAMA antimitochondrial antibodieCholestasisCRFs case record formsObeticholic acidOverlap PBC-AIHursodeoxycholic acidOCA obeticholic acidTolerabilityalkaline phosphataseRCTResearch Articlemedicine.drugcase record formsContext (language use)AMA antimitochondrial antibodiesInternal medicineEDC electronic data capturetransjugular intrahepatic portosystemic shuntInternal MedicinemedicineRCT randomised controlled trialaRR adjusted risk ratioOClcsh:RC799-869quality controlalanine transferaseASTaRRHepatologybusiness.industryAutoimmunity; Cholestasis; Cirrhosis; Overlap PBC-AIHAIH autoimmune hepatitisTCC Treatment Completer CohortPBC primary biliary cholangitiGGTrisk ratioOC Overall cohortALPlcsh:Diseases of the digestive system. GastroenterologyPBC primary biliary cholangitisbusinessEDC
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Postmetropoli in contesti al 'margine'

2014

Il sud Europa, ad eccezione del nord Italia, è considerato come una porzione 'marginale', la 'meno globale' del continente e fino a poco tempo fa c'era chi lo dipingeva come appartenente al 'Terzo Mondo'. La Sicilia e  considerata al limite di questa 'marginalità' e, per molte ragioni, lo è. Eppure, nuovi processi sono in corso. I territori siciliani stanno attraversando notevoli fasi di cambiamento fisico, sociale ed economico, mostrando una transizione, per molti aspetti inedita, verso forme post-metropolitane. Si tratta di aree per molti aspetti paradigmatiche in grado di restituire le diverse nature del 'post' sotto il profilo spaziale, economico, demografico e sociale. Si affronterà, d…

urban form urban growth representationSettore ICAR/21 - UrbanisticaSettore M-GGR/01 - Geografia
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Nonlinear black-box models for short-term forecasting of air temperature in the town of Palermo

2011

Weather data are crucial to correctly design buildings and their heating and cooling systems and to assess their energy performances. In the intensely urbanized towns the effect of climatic parameters is further emphasized by the Urban Heat Island (UHI) phenomenon, known as the increase in the air temperature of urban areas, compared to the one measured in the extra-urban areas. The analysis of the heat island needs detailed local climate data which can be collected only by a dedicated weather monitoring system. The Department of Energy and Environmental Researches of the University of Palermo (Italy) has built up a weather monitoring system that works 24 hours per day and makes data availa…

urban heat island.Settore ING-IND/11 - Fisica Tecnica AmbientaleMeteorologyartificial neural networks nonlinear black-box models MLP temperature short-term forecastingTerm (time)Weather stationNonlinear systemBlack boxAir temperatureClimatologyWeather dataEnvironmental scienceUrban heat islandIntensity (heat transfer)
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Pathways for the amplification of agroecology in African sustainable urban agriculture

2020

A growing awareness that highly intensified agricultural systems have made a substantial worldwide contribution to the worsening of the resilience capacity of natural ecosystems has, over the last twenty years, brought general attention to agroecological management models. This aspect is even more evident in industrial agriculture, which is based on the use of multiple chemical products derived from non-natural synthesis. In more developed countries, a new idea of ecology linked to agricultural production has been increasingly developed and, for this reason, there has been a greater diffusion of differentiated agricultural models taking into consideration the environmental impact of product…

urban small-scale agriculture; school garden; community garden; AfricaNatural resource economicsmedia_common.quotation_subjectlcsh:TJ807-830Geography Planning and DevelopmentPopulationlcsh:Renewable energy sources010501 environmental sciencesManagement Monitoring Policy and Law01 natural sciencesAfrica; Community garden; School garden; Urban small-scale agricultureAgricultural productivityUrban agricultureeducationAgroecologylcsh:Environmental sciences0105 earth and related environmental sciencesmedia_commonlcsh:GE1-350Sustainable developmenturban small-scale agricultureeducation.field_of_studycommunity gardenRenewable Energy Sustainability and the Environmentbusiness.industrylcsh:Environmental effects of industries and plants04 agricultural and veterinary sciencesNatural resourceSettore AGR/03 - Arboricoltura Generale E Coltivazioni Arboreelcsh:TD194-195AgricultureAfrica040103 agronomy & agricultureschool garden0401 agriculture forestry and fisheriesBusinessPsychological resilience
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Emergence of scattered and leapfrog urban development : from analytical proof to complex simulation outputs with realistic calibration

2013

International audience

urban sprawl[SHS.GEO] Humanities and Social Sciences/Geographymicro-economicsurban form[SHS.GEO]Humanities and Social Sciences/Geographycomplex systemsComputingMilieux_MISCELLANEOUS[ SHS.GEO ] Humanities and Social Sciences/Geography
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"Urbanistica e urbanisti: un sapere indispensabile, un futuro incerto" in "In folio" n. 19-2007

2007

Necessità e scarsa utilizzazione sociale dell'urbanistica e degli urbanisti

urbanistica formazione amministrazione politica territorio pianificazioneSettore ICAR/21 - Urbanistica
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Comparison of impact characteristics of different ice hockey arena dasher boards

2012

During last years the incidence and severity of ice hockey related concussions have been increased and, hence, something should be done to stop this growth. The main aim of this study was to find out how dasher board materials and structures affect impact characteristics and, thereby, the risk of concussions. The measurements were divided into two parts; in the first part, the physiological characteristics of body checks were determined in real game measurements, and the second part, consisted of simulation of body checks in the laboratory. High speed cameras and accelerometers were used to collect data. More flexible protective shielding material (dasher board B) resulted in lower peak for…

urheiluvammatimpact characteristicsstiffnessice hockeydasher boardturvallisuuspeak forcejääkiekkoconcussionstopping distanceliikuntatilatenergy absorptionliikuntapaikat
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Calf muscle activation strategies in healthy and injured achilles tendon conditions

2015

Artikkeliväitöskirja. Sisältää yhteenveto-osan ja neljä artikkelia. Article dissertation. Contains an introduction part and four articles.

urheiluvammatmyoelectric activitypositron emission tomographypohkeetkipulihaksetkulutussurface electromyographyeccentric rehabilitationglucose uptakeglukoosielektromyografiaisometric forcekuntoutuskantajännevammatvoimaharjoittelubiomekaniikkaliikuntavammatpositroniemissiotomografialihasvoima
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Usability Assessment of a UML-Based Formal Modeling Method Using a Cognitive Dimensions Framework

2008

Conceptual models communicate the important aspects of a problem domain to stakeholders. The quality of the models is highly dependent on the usability of the modeling method used. This paper presents a survey conducted on a method that integrates the use of a semiformal notation, namely the Unified Modeling Language (UML) and a formal notation, namely B. The survey assessed the usability of the method by using the grounded theory, the Cognitive Dimensions of Notations (CD) framework, and several criteria suggested by the International Organization for Standardization (ISO). Ten participants responded to the survey. The results suggest that the method is accessible to users when the princip…

usabilitysemiformal and formal notationscognitive dimensions (CD)empirical assessmentgrounded theory
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Métodos de formación a distancia en el ámbito universitario

2018

La formación pedagógica, así como el asesoramiento y la orientación psicopedagógica, constituye uno de los puntos de interés en los que se trabaja en la Universitat Politècnica de València (UPV). Para dar respuesta a las demandas formativas derivadas de ese eje, el Instituto de Ciencias de la Educación (ICE) es el responsable de contribuir a la mejora de la calidad de los procesos de enseñanza-aprendizaje, ofreciendo la formación y asesoramiento oportuno tanto a su profesorado como a su alumnado. En este sentido, cada vez más se va dando prioridad a los modelos de formación a distancia mediados a través de la plataforma de e-learning PoliformaT, adaptación de la plataforma de Open Source Sa…

uso de las TICsmodelo formativoplataforma educativa
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